INDEX
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A AC 200 ACD 121 N-Acetylserotonin 39 iV-Acetyltransferase 39 adrenergenic induction of 41 cyclic A M P induction of 43 pineal 39 induction of 41 N-Acetyltryptamine 39 Acid(s) amino, analogs 37 electrophoresis of fluorocitric 10 erythrofluorocitric 8 fluoroacetic 8 fluorocarboxylic 1-19 fluoro-dicarboxylic 2 fluorourocanic, effects on urocanase 31 inhibitory properties of F-carboxylic 3 monofluorocitric 7 isomers of 9 nicotinic 90,91 perfluoro-octanoic 129 substrate properties of F-carboxylic 3 Aconitase, cytoplasmic 12 Actinomycin 28 Activities of fluorohistidines, antiviral 29 Activity, ornithine decarboxylase 46 Adenosine 3',5'-monophosphate 39 Adipose tissue 91 Adrenalin 41 Adrenergenic agents 41 Adrenergenic induction of N-acetyltransferase 41 AI 201 5-AICAR 32,33 Alditol Ill Aliphatic fluorine 77 Alphamethyldopa 37 Alveolographic studies with R F C 178 Amethopterin 57 Amine drugs 77 Amino acid analogs 37 p-Aminobenzoylglutamate 60 3-Aminomethyl-pyridine 90,91 A M P , cyclic 43 Amphetamine 78 in rat brain 81 A M P induction of N-acetyltransferase, cyclic 43 8 0
Analgesia 190 Analogs, amino acid 37 Anesthesia, surgical 190 Anesthetic(s) concentration, median 200 cyclic diether 193 fluorinated volatile 190-206 hazards of fluorinated 191 index 201 potency for fluorinated 201 3,4-Anhydro-D-galactose 104 Antilipolytic drug 91 Antiviral activities of fluorohistidines 29 A T P synthesis 17
Β Benz[a]anthracene induction 43 Biochemistry of ring-fluorinated imidazoles 23-33 Biological disposition of R F C 181 Bonds, phosphate 38 Brain, amphetamine in rat 81 Brain, /?,/?-difluoroamphetamine in rat 81 Brominated fluorocarbons 171-186 Bronchography with R F C emulsions 180
C F-Carboxylic acids inhibitory properties of 3 substrate properties of 3 Catalysis of M D H 2 Catecholamines 41 CF dUMP 66 Chlorination, photochemical 198 p-Chloroamphetamine 88 Chloroform 191 Cholecystography 186 Chymotrypsin 38 Cis-trans perfluorodecalin emul sions 135-167 Citrate-isocitrate exchange 6 Complexes, Michaelis-Menten 2 Cyanosis 190 Cyclic A M P induction of N-acetyl transferase 43 Cyclic diether anesthetics 193 Cycloheximide 28 N-Cyclopropyl amines 92 Cytochalasin Β 101 Cytoplasmic aconitase 12 3
211 Filler; Biochemistry Involving Carbon-Fluorine Bonds ACS Symposium Series; American Chemical Society: Washington, DC, 1976.
212
BIOCHEMISTRY INVOLVING CARBON—FLUORINE BONDS
D Deaminase, liver microsomal 79 Deamination, oxidative 82 Defluorination of fluorocitrate 14 4- Deoxy-D-glucose 104 Deoxyfluoro-D-glucoses 101 Deoxyfluoro-monosaccharides 99-113 Dephosphorylation 38 Dibutyryl adenosine 3',5'-monophosphate 43 Dibutyryl cyclic AMP 43 Dibutyryl adenosine 3',5'-monophosphate 43 Dibutyryl cyclic AMP 43 Diether anesthetics, cyclic 193 Difluoro-oxalacetate 2 0,/?-Difluoro substitution 79-80 β,/^Difluoroamphetanune 83,86 in rat brain 81 Drug, antilipolytic 91 Drugs, amine 77 dUMP 57
Fluoro-dicarboxylic acids 2 Fluorohistidines, antiviral activities of 29 Fluorohistidines, effects on histidine ammonia-lyase 30 2-Fluorohistidine 26 4-Fluorohistidine 30 2-Fluoro-L-histidine 37 Fluoroimidazole(s) 26 ribosides 33 4-Fluoroimidazoles, synthesis of 24 Fluorourocanic acids, effects on urocanase 31 Fluroxene 191,192
G D-.Galactose Gastroenerography GI tract, RFC in the Gland, pineal D-Glucose Gluconeogenesis Glucose-6-phosphatase Gregaria, Schistocerca
104 173 175 39 99,104 7 38 109
£ E. coli, effect offluorocompounds on 29 Efflux, inhibition of isocitrate 16 Efflux, rates of isocitrate 15 Electrophoresis offluorocitricacid 10 Emulsions bronchography with RFC 180 cis-trans perfluorodecalin 135-167 of RFC 180 Enflurane 191,192 Enzymatic probes 1-19 Enzyme induction 37, 43 Enzymes, histidine in 37 Erythrocyte membrane, human 99 Erythrofluorocitrate 11 Ervthrofluorocitric acid 8 Etners, synthesis of fluorinated 193 Ethylamine 77 Ethylene carbonate 194 Exchange, citrate-isocitrate 6 F FdUMP 59 5- FICAR 32,33 Fluorinated volatile anesthetics 190-206 Fluorine, aliphatic 77 Fluoroacetic acid 8 Fluoro compounds, effect on E. coli 29 Fluorocarbons, brominated 171-186 Fluorocarbons of high vapor pressure 176 Fluorocarboxylic acids 1-19 Fluorocitrate 7 defluorination of 14 Fluorocitric acid, electrophoresis of 10 5-Fluoro-2'-deoxyuridylate 59
H Halothane 191 effects on mice 202 Hazards offluorinatedanesthetics .... 191 Hepatocytes 143 Hepatography 185 Histidine 28 ammonia-lyase, effects of fluoro histidines on 30 in enzymes 37 incorporation into protein 50 Human erythrocyte membrane 99 Human plasma 117-133 HydTOxylindole-O-methyltransferase.
Hyperlipoproteinemia Hyperthermia Hypotensive effect
50
90 83 137
I Imidazole(s) 26 biochemistry ofring-fluorinated..23-33 pharmacology of ring-fluorinated 23-33 Incorporation of ( H) 2-fluoro-Lhistidine into protein 52 Incorporation of histidine into protein 50 Induction of N-acetyltransf erase, adrenergic .. 41 of Ν-acetyltransferase, cyclic AMP 43 benz [ a ] anthracene 43 enzyme 37,43 of pineal N-acetyltransferase 41 steroid 43 Inhibition of isocitrate efflux 16 Inhibition of monoamine oxidase 94 3
Filler; Biochemistry Involving Carbon-Fluorine Bonds ACS Symposium Series; American Chemical Society: Washington, DC, 1976.
213
INDEX
Inhibitory properties of F-carboxylic acids 3 Intraabdominal surgery 190 Isocitrate efflux, inhibition of 16 Isocitrate efflux, rates of 15 Isomers of monofluorocitric acid 9 Isoproterenol 41,55
L Lactobacillus casei LC Lethal concentration, median Lipolysis Lipophilicity Liver microsomal deaminase Locusta migratoria Lymphography 5 0
57,72 200 200 90 201 79 109 181
M M D H , catalysis of 2 Median anesthetic concentration 200 Median lethal concentration 200 Melatonin 39 Membrane, human erythrocyte 99 Metabolic probes 1-19 Metabolism, sorbital Ill Methoxyflurane 191,192,201 N-Methyltransferase 79 Mice, halothane effects on 202 Michaelis-Menten complexes 2 Microsomal deaminase, liver 79 Migratoria, Locusta 109 Mitochondrial monoamine oxidase .... 80 Monoamine oxidase, inhibition of 94 Monochloroethylene carbonate 194 Monodeoxy-D-glucoses 99 Monodeoxymonofluoro-D-glucoses 99-100 Monofluorocitric acid 7 isomers of 9 Monofluoro-malate 5 Mosquito 111 Multienzymatic processes 1 Muscle relaxation 190
Ν Narcosis Nicotinic acid Norepinephrine
190 90, 91 83,92 Ο
Organic fluoro compounds Ornithine decarboxylase activity Oxidase, inhibition of monoamine Oxidative deamination
117-133 46 94 82
Ρ Pancreatography 186 Para-chlorophenylalanine 37 Para-fluorophenylalanine 37 Perfluorochemicals 135 Perfluorodecaline 135,147 emulsions, cis-trans 135-167 Perfluorohexylbromide 185 Perfluoro-octanoic acid 129 Peritoneal contamination 175 PFC 135 PFD 135 Phagocytosis of R F C 176 Pharmacology of ring-fluorinated imidazoles 23-33 Phenethylamine 84 C-Phenethylamine 86 Phosphate bonds 38 Phospholipid 147 Phosphorylations 38 Photochemical chlorination 198 Pineal N-acetyltransferase 39 induction of . 41 Pineal gland 39 Polyols HI Potency for fluorinated anesthetics 201 Pressure, fluorocarbons of high vapor 176 Probes, enzymatic 1-19 Probes, metabolic 1-19 Processes, multienzymatic 1 Protein, incorporation of ( H ) 2 fluoro-L-histidine into 52 Protein, incorporation of histidine into 50 Ps. aeruginosa 107 Ps. fluorescens 107 Pseudomonad 107 Ptosis 203 Pyrimidines 67 14
3
R Radiopaque fluorocarbon 173 Rat brain, amphetamine in 81 Rat brain, /?,^difluoroamphetamine in 81 Rates of isocitrate efflux 15 Relaxation, muscle 190 RFC 173 alveolographic studies with 178 biological disposition of 181 emulsions 180 bronchography with 180 in the GI tract 175 phagocytosis of 176 submersion in 176 Ribavirin 32 Ring-fluorinated imidazoles biochemistry of 23^33 pharmacology of 23-33 RNAse 38
Filler; Biochemistry Involving Carbon-Fluorine Bonds ACS Symposium Series; American Chemical Society: Washington, DC, 1976.
214
BIOCHEMISTRY
S Schistocerca gregaria 109 Serine 38 Silk worm Ill Sorbitol dehydrogenase Ill Sorbitol metabolism Ill Splenography 185 Steroid induction 43 Submersion in R F C 176 Substrate properties of F-carboxylic acids 3 Surgery, intraabdominal 190 Swallowing reflex 190 Synthesis ATP 17 of fluorinated ethers 193 of 4-fluoroimidazoles 24 Synthetase, thymidylate 57-74
Τ Tachypnea Threonine
203 38
INVOLVING C A R B O N - F L U O R I N E
BONDS
Thymidylate synthetase 57-74 Tissue, adipose 91 TMP 57 Toxicity of 3-deoxy-4-fluoro-D-glucose 109 Triethyl fluorocitrate, N M R of 10 β,β,β-Trifluoroethylamine 77 5-Trifluoromethyl-2'-deoxyuridylate .. 66 Tryptamine 39
U Urocanase, effects of fluorourocanic acids on Urography
31 186
V Vapor pressure, fluorocarbons of high Vasodilatation Ventriculomyelography Vinylidene carbonate
Filler; Biochemistry Involving Carbon-Fluorine Bonds ACS Symposium Series; American Chemical Society: Washington, DC, 1976.
176 90 185 195
