1-Formyl-A-nor-5P-androst-1 - American Chemical Society

samandaridine, 0-a~etylsamandarine,~ and samandes- one,6 which differ from each other only in the D-ring substituent. We wish to record the total synt...
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1041 Table 11. Comparison of Infrared Spectraa Assignment

( M ~ A s B H z()M ~ ~ P B H z ) ~(MzPBDz)~

1889 (1.1) 1794(0.9) C-F stretching 1205 (400) 1192(265) 1164 (160) BH2 deformation? 952 w 852 w BH2 out-of-plane rock 960 (33) 995 (4) 755 (1.6) CF3 sym deformation 742 (20) 764 (0.8) 761 sh (1.2) BH2 in-plane rock 636 ? w 715 (17) 566 (9) CF3 asym deformation (Too weak) 538 (3.6) 532 (2.0) , . , . . . As-CF3 stretching 332(17) P-CFJ stretching . . . 455 (6) 444 (6) 436 (7) 431 (5) 414 (5) 409 (0.7) Uncertain 659 (10) 662 (12) 621 (3) 602 (20) 554(1.5) 395 (2.2) B-H stretching

2530 (6.5) 2449 (3.9) 1190 (410) 1154(160) 1123 (145) 1075 (5.3)

2514 (2) 2429 (0.6) 1206 (170) 1192(167) 1164 (100) 1152 w, sh

~

0

~

~~~

characteristic skeleton of samandarine is common to four other alkaloids, Le., samandarone (IIa),2 samandaridine, 0-a~etylsamandarine,~ and samandesone,6 which differ from each other only in the D-ring substituent. We wish to record the total synthesis of samandarone, which will be a general intermediate for the preparation of structurally similar alkaloids.

R

N

w

H Ia, R = X = H ; X ’ = O H b, R=PhCH2; X = O H ; X’=H C, R = X ’ = H ; X = O H

-

M = CF3; w = weak; sh =shoulder.

through farmation of its acetyl chloride complex at - 1lo”, and HC1 was similarly removed as the (CH&O complex, leaving a trace of SiF,. The result was 2.06 HCl and 1.04 BF3 (both h5%) per calculated (CF3)2AsBH:! unit. Thus the elementary analysis was complete, fully confirming the formula [(CF&AsBHgla. Infrared Spectra. The frequencies (cm-l) of the infrared fundamental peaks observed for [(CF&AsBH2I3 in the vapor phase at 1.2 nim pressure (33”) are compared with the analogous peaks for [(CF3)2PBH2Ia and [(CF&PBD2I3 in Table 11. The relative intensity appears in parentheses after each frequency. Discussion. The 960-cm-’ peak for BH2 out-ofplane rocking fits a previously recognized trend.j By comparison with the 812-cm-’ peak observed for [(CHa)2PBH2]B and other pertinent data for such compounds, the 995-cm-l peak suggests that the HBH angle in [(CF&PBH2I3 might be as much as 10” wider than the 119.3” reported for [(CH3)2PBH2]3.6Also, two different methods estimate the HBH angle as 2.5 to 2.8” narrower in [(CFy)?AsBH2Isthan in [(CF&PBH2I3. The latter comparison would agree with the expectation that As4