1.; ,I - ACS Publications - American Chemical Society

The advent of. I3C/l5N isotopic enri~hmentl-~ and heteronuclear multidimen- sional experiments4q5 has greatly extended the size of proteins for which ...
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J. Am. Chem. SOC. 1995,117, 9592-9593

9592

Use of 'HN-~HN NOEs To Determine Protein Global Folds in Perdeuterated Proteins Ronald A. Venters,' William J. Metzler,* Leonard D. Spicer,*95 Lucian0 Mueller,* and Bennett T. Fanner II*,t

Duke University NMR Center and Departments of Biochemistry and Radiology, Duke University Medical Center, P.O. Box 3711, Durham, North Carolina 27710 Bristol-Myers Squibb Pharmaceutical Research Institute P.O.Box 4000, Princeton, New Jersey 08543-4000 Received May 22, 1995 NMR structural studies on isotopically unlabeled proteins are typically limited to those with