203rd ACS National Meeting - American Chemical Society

Apr 5, 1992 - rectors, ACS short courses, and a na- ..... Atomic spectroscopy of automotive .... Near-field optical microscopy and ..... M. E. Munk, E...
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203rd ACS

National Meeting

San Francisco, CA April 5-1021992 The 203rd nationa meeting of the American Chemical Society will be held m San Francisco, CA, April 5 - 1 0 . The Division of Analytical Chemistry will sponsor or cosponsor technical sessions at which more than 180 paesentations are schedThe meeting will feature a presidential plenary sessionc "An Evening of Literature Music, and Dance for and by?) Chemists" (Monday, April 6) and a career development tutorial, "Expanding Your Options" (Sunday, April 5 and Monday, April 6 ]- ? t h e r highlights include meetings of the ACS Council and Board of Directors, ACS short courses, and a national employment clearinghouse. Social events include the ACS SciMix (Monday April 6); an alumni hour (Wednesday, April 8); the 1992 ACS Awards reception, dinner, and awards presentation (Tuesday, April 7); and the Division of Analytical Chemistry poster sess,on and mixer (ounday, April o) and sociLl hour and dinner (Monday April 6)





On-site registration facilities in the Moscone Center, lobby level, will be open Sunday; April 5, from 2 to 7 P.M.; M o n d a y A p r i l 6, , h r o u g h Thursday, April 9 from 7:301 A.M. to 3:30 P.M.; and Friday, April 10, from 7:30 to 10 A.M. An exposition of approximately 425 booths representing 235 companies and organizations will disp ay instruments chemicals technical literature, and other products and services for four days during the meeting. Located in Halls A and B of the Moscone Center, the exposition will open Monday, April h>, Irom o to J.ol)

The technicaw p r o g r a m wilo be highlighted by the presentation of several awards at symposia sponsored by the Division of Analytical C h e m i s t r y On Tuesday, April 7, ^ r J y , R - F u l l m e r will receive the ACS A w a r d i n Analytical Chemistry and will dehver a talk titled "Understanding Electrochemical Dynamics: P r e s e n t Capabilities and Limitations." The ACS Award in Chromatography will bepresented to Joseph F. K. Huber, who will deliver a talk titled "Separation, the Key to Multidimensional Analytical Chemistry"

HunEEIEE oYINIG5£5 floor. 9 h e exposition will be open from 9 AM. to 5 P.M. on Tuesday and Wednesday, April 7 and 8, and from 9 A.M. to noon on Thursday, April 9. Admission is complimentary Again this year a series of exposition workshops on a variety of topics will be held, and several ACS diviiTt^^xposXrha1!!1508^868810118

388 A • ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992

standing Achievement in Mass Spectrometry on Friday, April 10. His address, "CIMS: Chemistry in Mass Spectrometry, from Fundamentals to Applications and Back Again," will be presented Friday morning Milos V. Novotny will receive the ACS Award in Separations Science and Technology on Thursday morning, April 9, during a symposium

cosponsored with the Division of In­ dustrial and Engineering Chemistry. His talk is titled "Analytical Separa­ tion Science in Our C h a n g i n g World." Other division sessions will cover topics such as chemical analysis in the electronics industry, l a s e r - m a t e ­ rials interactions, chemical diag­ nostics for chemical and materials sciences synthesis processes, new an­ alytical applications of piezoelectric sensors, and supramolecular assem­ blies on surfaces. Biologically ori­ ented symposia organized by the Subdivision of Chromatography and Separations Chemistry will include one on preparative bioseparations and another on the use of tryptic mapping to characterize recombinant DNA-derived proteins. The Division is also cosponsoring a symposium with the Committee on

Environmental Improvement and the Division of Environmental Chemis­ try on regulatory problems and solu­ tions with method detection limits. Several other symposia of interest to analytical chemists include Biotech­ nology a n d t h e H u m a n G e n o m e Project (cosponsored by the Biotech­ nology Secretariat and the Division of Chemical Health and Safety), An­ alytical Technology in Characteriz­ ing Protein Pharmaceuticals (spon­ sored by the Division of Biochemical Technology), The Role and Future of Independent Testing Labs (cospon­ sored by the Division of Small Chem­ ical Businesses and the Division of Agrochemicals), and Chemical Appli­ cations of Neural Networks (cospon­ sored by the Division of Computers in Chemistry). The Division of Analytical Chemis­ try dinner is scheduled for 6:30 P.M.

on Monday, April 6, at the Fairmont Hotel. Tickets, which are $35, are available from Joseph L. Glajch, The Dupont Merck Pharmaceutical Com­ pany, 331 Treble Cove Rd., Building 2 0 0 / 1 , North Billerica, MA 01862 (508-671-8413; fax 508-436-7500). A social hour will precede the dinner. The ACS Department of Continu­ ing Education will offer a series of short courses at the meeting. For ad­ ditional information, see p. 395 A. General information can be found in the J a n . 23 issue of Chemical & En­ gineering News. The technical pro­ gram and exposition exhibitors and workshops appear in the March 3 is­ sue. The program that follows includes all sessions sponsored or cosponsored by the Division, as well as selected sessions of i n t e r e s t to a n a l y t i c a l chemists.




SUNDAY EVENING Sheraton Palace Concert Ballroom, First Floor Poster Session/Social Hour

12. 13.

C. L. Wilkins, Presiding 7:00-10:00 1.


3. 4.

5. 6.


8. 9.


Laser ablation of metal films at the electrode surface of a quartz crystal microbalance. J. Pérez, B. Reyes, B. R. Weiner Analysis of polycyclic aromatic hydrocarbons in soots using laser desorption-laser photoionization MS. C. H. Smith, M. K. Young, P. B. Kelly, A. D. Jones Analyte carryover and signal enhancement in particle beam MS. J.Hsu Application of laser microprobe MS for the determination of aluminum in spinal cord from amyotrophic lateral sclerosis and control patients. L. Tandon, M. A. Lovell, W. D. Ehmann, E. J. Kasarskis Ionization energy-modulated MS. D. S. Bomse, J. A. Silver, D. C. Hovde Measurement of boron concentration and isotope ratios in biological samples by ICPMS with direct-injection nebulization. F. G. Smith, D. R. Wiederin, R. S. Houk, C. B. Egan, R. E. Serfass GC/MS analysis of butyl esters of anionic surfactants using supercritical fluid/ion pair extraction. D. J. Miller, S. B, Hawthorne, J. A. Field Capillary electrophoresis/electrospray MS for recombinant proteins. K. Tsuji, L. Baczynskyj, G. E. Branson Chiral separations by capillary electrophoresis using cyclodextrin derivatives. I. Cruzado, Y. Rawjee, G. Vigh Mass spectrometric assay for the major urinary metabolite of thromboxane B2. A. Ferretti, V. P. Flanagan, E. J. Maida



16. 17.


19. 20.

21. 22.


Electrocatalytic oxidation of biologically relevant substrates at electrodes modified with conductive metallophthalocyanine polymers. T. F. Guarr, F. Xu, H. Li Fast-responding potentiometric carbon dioxide sensor. M. J. Tierney, H-O.L. Kim, J. Joseph, T.Otagawa Quantitative conductivity measurement using microfabricated, interdigitated electrodes. N. F. Sheppard, Jr., R. C. Tucker Fluorometric determination of chloroform in drinking water with a fiber-optic chemical sensor. J. D. Ingle, Jr., J. Louch Determination of chromium(lll) and chromium(VI) with a two-column ion-exchange system. J. D. Ingle, Jr., P. A. Sule M-l-M'tunnel diodes as chemical sensors. K. W. Hlpps, U. Masur Correlation of electrode function and chemical architecture at 8-μΓη carbon fiber microelectrodes. P. Pantano, P. Hopper, W. G. Kuhr Development of a biocatalytic chemiluminescence reaction sequence for synaptic glutamate microscopic mapping. L. Li, A. J. Wang, M. A. Arnold, J. S. Dordick Comparison of two fluorescence reaction schemes for a fiber-optic glutamate biosensor. A. J. Wang, M. A. Arnold Use of renewable reagent-based fiber-optic chemical sensors for determining environmental pollutants. R. Duesing, P. T. Vanneau, J. Henshaw, L. Wangen Fiber-optic biosensor for sulfite measurement. Z. M. Shakhsher, A. Suleiman, G. G. Guilbault Detection of hazardous materials in groundwater with SERS fiber-optic probes. K. Carron, K. Mullen, G. Hurley, D. X. Wang FT-IR study of Bacillus thuringiensis crystal proteins. R. E. Harry-O'Kuru, S. H. Gordon, K. W. Nickerson, L. H. English, R. V. Greene

25. 26. 27. 28. 29. 30.

31. 32.

33. 34. 35. 36. 37. 38. 39.

Physiological salinity and oxygen as the keys for differentiation of the enantiomeric isomers of amino acids in biosynthesis. S. Fujiwara, Y. Nishimoto Fused-silica capillary waveguides and their application to micro-LC with LIF detection. A. A. Abbas, D. C. Shelly Use of chitosan as a chelating agent in metal determinations. I. T. Urasa, J. C. Arce Spectrophotometric determination of hydroquinone in photographic materials. U. M. Krishna, J. A. Murty Polarization/orientation micro- Raman spectroscopy for the analysis of solids. D. D. Tuschel Construction of new surface-enhanced Raman scattering substrates. R. G. Freeman, M. J. Natan SERS studies of dimerization of viologen cation radicals in self-assembled monolayers: Origin of unusual waveshapes in the voltammetry of monolayers. D. A. Buttry, X. Tang Self-assembled monolayers of n-alkanethiol-linked nucleotides. D. Albagli Supramolecular assemblies of octa-substituted phthalocyanines on surfaces: Synthesis, optical, and photoelectrochemical characterization. E. J. Osburn, L-K. Chau, D. F. O'Brien, N. R. Armstrong Cation transfer in anthraquinone monolayers self-assembled on EQCM gold electrodes. S. L. Hiley, D. A. Buttry EQCM measurements of reductive desorptions of n-alkanethiol monolayers on gold. T. W. Schneider, D. A. Buttry Studies of multichannel photothermal refraction for the measurement of absolute absorptivity. L. N. Klatt Polyaniline: Photoacoustic spectrum. I-U. Haque Atomic spectroscopy of automotive catalytic converters. D. Zetik, N. E. Takach, K. D. Wisecarver Effect of alkyl spacer groups between a silicon atom and a phenyl ring in HPLC. Y-L. Chen, J. O. Archer Solvatochromic studies of solvated silica and bonded silica phases. R. S. Helburn, S. C. Rutan

ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992 · 389 A


41. 42. 43. 44. 45. 46.

47. 48. 49.







56. 57.


59. 60.

61. 62.

Automated ruggedness evaluation of HPLC assay procedures using experimental design. S. W. Shea, L. S. Hacche, D. F. Marsh Comparison of alkyl-bonded alumina stationary phases for peptide separations by HPLC. J. E. Haky, N. D. Ramdial Extraction of substituted phenols using bonded solid-phase extraction cartridges. J. O. Archer, Y-L. Chen Counterion effects in reversed-phase HPLC of phospholipids. S. L. Abidi, T. L. Mounts Monitoring of butyrylcholine esterase activity by LC. M. Chelmiska-Bertilsson, S Allenmark Direct HPLC separation of enantiomeric peptidoleukotriene antagonists. T. K. Chen, R. Mills Detection of thiodiglycol and its sulfoxide and sulfone analogues in environmental waters by HPLC. P. C. Bossle, M. W. Ellzy, J.J. Martin Effects of salts on protein-free solution capillary electrophoresis with acidic pH buffers. B. R. Sunday, W. Sydor Progress in oxide particle separations by CZE. S. L. Petersen, N. E. Ballou Application of capillary electrophoresis to pharmaceutical analysis: Quantitative analysis of alendronate in dosage forms. M. M. Singh, E. W. Tsai, H. H. Lu, D. P. Ip. M. A. Brooks Chemiluminescence detection in capillary electrophoresis. L. A. Colon, R. Dadoo, R. N. Zare HPCE of a homologous series of hydrophilic peptides. B. R. Sunday, J. Raman, R. Bordens, L. Ramanathan, M. Rosenthal HPLC method and degradation profile development of Roche drug, Ro 24-5913. N. D. Aggarwal, A. W. Malick. D. Goldman, K. Sethachutkul HPLC with pulsed amperometric detection of diols from the degradation of poly(ortho)esters. K. E. Heppert, W. R. LaCourse, R. D. Shaffer Supercritical fluid/ion pair extraction of anionic surfactants from sewage sludge. J. A. Field, D. J. Miller, S. B. Hawthorne, W. Giger Quantitative extraction/derivatization procedure for the capillary column GC analysis of phenol and its metabolites in aqueous biological media at a parts-per-billion level. L. A. Jones, J. J. Glennon, J. H. Praebel. M. R. Copeland, R. J. Kavlock Chemical derivatization/SFE of polar and ionic analytes. S. B. Hawthorne, D.J. Miller Comparative study of computational analysis techniques for deconvolution of multiplex gas chromatographic data. M. Shao, K. W. Hall, J. R. Valentin, J. B. Phillips MOPSO. a recommended alternative to phosphate-based pH standards. P. A. Berezansky, Y. C. Wu, D. Feng. W. F. Koch Vacuum vapor pressure osmometer (VVPO): New designs. T. Ogura, R. Casillas V., R. Gonzalez L. Development of a soil water vapor analyzer for Mars missions using chemical modulation. M. D. Dao, J. R. Valentin, A. Banin, J. B. Phillips Withdrawn. Conformational analysis of hexaacetate methylcalix[6]arene by NMR. Y. Nakahara, N. Mita. Y. Ohnishi, Κ. Tateishi




66. 67. 68. 69.

70. 71.


73. 74. 75.

Comparison of the absorbance ratio and sequential chromatogram ratio techniques for improved data analysis by mathematical suppression of interfering components. T. J. Bahowick, D. R. Dunphy, R E. Synovec Molecular-weight determination of water-soluble polymers by FIA with refractive gradient detection. V. Murugaiah, R E. Synovec Voltammetric determination of selenium: Comparison of electrode and microelectrode geometries. W. J. Bowyer, M. E. Hrehocik, J. S. Lundgren Evaluation of methods to determine sulfate in water matrices. R. H. Altman Isolation and analysis of nanogram quantities of vitamin Κ in tissues. G. H. Dialameh Analysis of crude o,o-diethyl phosphorochloridothioate. M. Goodman, S. Dinizo, D. Bowler Unexpected post-translational modification observed in a recombinant protein biosynthesized in Chinese hamster ovary cells. E. Canova-Davis, V. T. Ling, M. L. Eng Characterization of caffeoyltartronic acid from catnip: A caffeoylglycolic acid mimic. M. E. Snook, M. S. Blum Chemical transformation: Determination of benzo[a]pyrene tetrahydrotetrol as a model DNA adduct. S. Abdel-Baky, K. Allam, R. W. Giese Tautomeric phenomenon of FK506 in solution. Y. Namiki, N Kihara. M. Fujioka, K. Shimatani, A. Fujiwara, K. Hane, T. Yasuda Analytical SPLITT fractionation: A new approach to rapid particle size analysis. C. B. Fuh, M. N. Myers, J. C. Giddings Separation of particles by thermal FFF. G. Liu, J. C. Giddings Dynamic response characterization of the chloride ion selective electrode. V. Y. Young, M. L. Clay, S. Hoke

390 A · ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992


MONDAY MORNING Sheraton Palace Sea Cliff, Second Floor

Chemical Analysis in the Electronics Industry—I T. D. Harris, Organizer, 9:00 9:45

10:30 11:00



Electronic materials characterization: Needs for the 1990s and beyond. J. W. Mitchell Approaching compositional analysis of single particles in air. W. D. Reents, Jr., A. J. Muller. S. W. Downey. D. J. Siconilfi, A. M. Mujsce. M. P. Green, J. D. Sinclair Near-field optical microscopy and spectroscopy of submicron features. J. K. Trautman, E. Betzig In situ microscopy studies of interface formation. R. M. Tromp, M. C. Reuter, A. D. van der Gon Scanning probe metrology. J. E. Griffith SECTION Β

Sheraton Palace Pacific Heights, Second Floor 1992 ACS Award in Chromatography Symposium Honoring J.F.K. Huber—I J. J. Kirkland, Organizer. 9:00 9:15 10:00 10:30 11:15 11:45


Introduction ot Awardee. Award Address. Separation, the key to multidimensional analytical chemistry. J.F.K. Huber Capillary zone electrophoresis of oligosaccharides. C. Horvath, C. Chicso, M. Spellman Selectivity in chromatography: Where do we go from here? L. R. Snyder Prediction of overload in electrophoresis from first principles. H. Poppe Conformational manipulation in biopolymer separation in capillary electrophoresis. B. L. Karger



Sheraton Palace Sonoma, Second Floor Preparative Bioseparations I. Chromatographic Techniques Cosponsored by Subdivision of Chromatography & Separations Chemistry J. Rivier, C. F. Ivory, J. Rivier, Presiding 8:50 9:00 9:45




4:00 4:30

Characterizing the opto-electronic properties of semiconductor materials using optically excited scanning tunneling microscopy. R. J. Hamers Analysis of water-soluble paste residues. M. C. Russ, D. Coolbaugh, S. Rose, D. Walker Quality assurance of polycrystalline CVD diamond materials for electronic applications. L. Siebles


2:25 2:50 3:15



Introductory Remarks. Keynote Address. Recent developments in immobilized metal ion affinity chromatography (IMAC). J. Porath Multidimensional HPLC strategy for the purification of proteins and peptides for microsequence analysis. E. C. Nice, L. Fabri Analysis of therapeutic monoclonal antibodies by capillary electrophoresis. N. A. Guzman, J. Moschera, K. Iqbal, A. W. Malick Large-scale purification and characterization of synthetic bioactive peptides for clinical investigations. C. Hoeger, C. Miller, D. Kirby, J. Rivier Rules of thumb for critical displacer properties in protein displacement chromatography. S. M. Cramer

Sheraton Palace Pacific Heights, Second Floor 1992 ACS Award in Chromatography Symposium Honoring J.F.K. Huber—II

3:15 3:45 4:15

TUESDAY MORNING Sheraton Palace Sea Cliff, Second Floor

Use of electrospray MS in the characterization of rDNA-derived proteins. W. S. Hancock, A. Guzzetta, V. Ling, E. Canova-Davis Use of small particles in modern LC. J. C. Kraak, H. Poppe Chemical analysis of a single red blood cell. E. S. Yeung, B. L. Hogan Superficially porous silica microspheres ("poroshell") for the fast HPLC of macromolecules. J. J. Kirkland

R. E. Russo, P. Arrowsmith, R. E. Russo, Presiding 9:00 9:40 10:30 11:10


SECTION D Moscone Center Room 2 5 2 - 2 5 4 , Mezzanine Level

Sheraton Palace Sonoma, Second Floor

Role and Future of Independent Testing Laboratories Sponsored by Division of Small Chemical Businesses and Division of Agrochemicals

Preparative Bioseparations II. Perspectives Cosponsored by Subdivision of Chromatography & Separations Chemistry

E.W.D. Huffman, Jr., Presiding

C. F. Ivory, Presiding

9:00 9:10

1:50 2:00

9:35 10:00 10:45 11:10 11:35

Introductory Remarks. Independent testing laboratories: Past, present, and future. J. F. O'Neil How to use your analytical laboratory more effectively. E.W.D. Huffman, Jr. Environmental laboratories and the ways they are working together. R. L. Northlngton Computerization, automation, and data management in the commercial lab of the 1990s. C.B. Godfrey Role of analytical laboratories in agriculture. N. B. Dellavalle NIST services for measurement quality assurance: An overview and the outlook for biotechnology. L. J. Powell

MONDAY AFTERNOON Sheraton Palace Sea Cliff, Second Floor

2:30 3:00 3:30




Laser-Material Interactions: Fundamentals and Applications—I

L. R. Snyder, Presiding 2:00

Redefining detection and quantitation and their application to standard setting in the drinking water program. H. J. Brass, M. Gomez-Taylor A state's perspective on analytical measurements in the standard-setting process. J. A. Krueger Regulatory aspects of detection and quantitation limits. A. F. Haeberer, N. W. Wentworth ASTM activities regarding analytical detection in water. P. W. Britton


Ablation processes with UV excimer lasers. R. W. Dreyfus Laser-solid interaction: Plume dynamics and condensed-phase processes. A. Vertes Ultrafast microscopy and ultrafast calorimetric studies of laser polymer ablation. D. D. Dlott Dynamics of laser ablation by spectroscopic and nanosecond time-resolved thermal techniques. C. E. Otis SECTION Β

Sheraton Palace Pacific Heights, Second Floor 1992 ACS Award in Analytical Chemistry Symposium Honoring L. R. Faulkner—I

Introductory Remarks. C. F. Ivory Chiral displacement chromatographic separations in the normal-phase mode. G. Vigh, P. L. Camacho, C. Piggee The other corner of the triangle: Throughput aspects of process chromatography. J. C. Baker Industrial perspective on downstream processing. B. Bridenbaugh, T. McNerney, E. Clapp, R. van Reis Development of a production-scale purification process for GM/IL-3 fusion protein (PIXY 321). J. T. Dunn, S. Waugh, H. Madani, L. Phan, H. Sassenfeld Purification challenges for recombinant protein C from the milk of transgenic pigs. W. H. Velander, T. Morcol, A. Degener, A. Subramanian

M. Majda, Organizer, 9:00

9:45 10:25



Award Address. Understanding electrochemical dynamics: Present capabilities and limitations. L. R. Faulkner User-friendly electroanalysis. B. R. Shaw, Y. Deng, J. Park, C-L. Wang Incorporation of redox-active cations into tungsten oxide coatings on electrodes: Enhancement of coating stability and electrocatalytic activity. F. C. Anson, J-F. Roland Flux enhancement in composite ion-exchange polymers. J. Leddy, Y. Fang SECTION C

Sheraton Palace Sonoma, Second Floor SECTION D

Chemical Analysis in the Electronics Industry—II

Marriott Nob Hill, Yerba Buena Level

J. W. Mitchell, Organizer, Presiding

Regulatory Problems and Solutions with Method Detection Limits Cosponsored with Committee on Environmental Improvement and Division of Environmental Chemistry, Inc.

1:30 2:15


Device performance materials properties interface: New challenges for characterization. T. O. Harris Chemometrics and IR spectroscopy for the analysis of thin-film dielectrics. D. M. Haaland, B. Wangmaneerat, T. M. Niemczyk Resonance ionization MS of device materials: Beyond SIMS. S. W. Downey, A. B. Emerson

L. H. Keith, Organizer, 1:30


Revised concepts for reporting data near method detection levels. L. H. Keith, D. L. Lewis

Preparative Bioseparations III. Nonchromatographic Techniques Cosponsored by Subdivision of Chromatography & Separations Chemistry C. F. Ivory, Presiding 8:50 9:00

Introductory Remarks. Protein solubility in aqueous electrolyte solutions. H. W. Blanch, C. J. Coen, J. L. George, E. Shih, D. E. Kuehner, J. M. Prausnitz

ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992 · 391 A

MEETINGS TUESDAY AFTERNOON Sheraton Palace Sea Cliff, Second Floor


Laser-Material Interactions: Fundamentals and Applications—II A. Vertes, Presiding 1:30


2:30 3:20 3:50 4:20

Mechanisms of laser-surface interactions, optical surface damage, and the initiation stage of surface ablation. L. L. Chase, A. V. Hamza. H.W.H. Lee Interaction of wide band-gap materials with UV excimer irradiation. J. T. Dickinson, L. C. Jensen, S. C. Langford Effects of operational parameters on energy coupling during pulsed laser welding. D. A. Cremers, G. K. Lewis Fluorescence imaging in matrix-assisted laser desorption E. S. Yeung, T. W. Heise Excimer laser ablation of thin liquid films. A. C. Tarn Laser deposition and laser modification of high-temperature superconducting thin films. N. S. Nogar, R. C. Dye, S. R. Foltyn, R. E. Muenchausen, X. D. Wu SECTION Β

Sheraton Palace Pacific Heights, Second Floor 1992 ACS Award in Analytical Chemistry Symposium Honoring L. R. Faulkner—II B. Shaw, 2:00

2:40 3:35 4:15 9:45 10:15 10:45 11:15

Aqueous two-phase extraction: Experiment and theory. C. K. Hall, P. Kenkare. D. Forciniti. M. R. Kula Electrically driven ultrafiltration. C. F. Ivory, W. A. Gobie Scale-up of isoelectric focusing using simple buffers. M. Bier, T. Long Continuous SPLITT fractionation of biopolymers and bioparticles. J. C. Giddings, C. B. Fuh, J. Zhang. M. N. Myers

SECTION D Marriott Marina A, B, & C, Yerba Buena Level Analytical Techniques in Characterizing Protein Pharmaceuticals Sponsored by Division of Biochemical Technology M. B. Sliwkowski, Organizer, 8:30 8:35







Introductory Remarks. Glycoprotein characterization by group-selective ion-exchange HPLC. J. Frenz, C. P. Quan


Glycosylation stability and production consistency of therapeutic glycoproteins expressed in CHO cells. M. Yet, R. Camphausen, T. McDonagh, D. Cumming Glycosylation of a recombinant monoclonal antibody expressed in several cell lines. C. C. Yu Ip, W. J. Miller. C. N. Oliver, D. M. Krips. J. G. Aunins, G. Cuca, D. J. Distefano, S. Gould, C. Seaman, M. Silberklang, G. E. Mark. R. W. Ellis Direct carbohydrate analysis of glycoproteins electroblotted onto PVDF membranes M. Weitzhandler. D. Kadlecek, N. Avdalovic, R. R. Townsend Quantification of lectin affinity chromatography using automated monosaccharide analysis. J. S. Rohrer, R. R. Townsend Rapid analysis of the glycosylation of recombinant proteins. R. B. Parekh, T. P. Patel Immunochromatographic analysis of proteins. A. Riggin, J. R. Sportsman, F. E. Régnier

392 A · ANALYTICAL CHEMISTRY. VOL. 64, NO. 6, MARCH 15, 1992



Investigations of ultrasmall volumes and short times with the scanning electrochemical microscope. A. J. Bard, F-R. Fran, M. V. Mirkin, D. T. Pierce, P. R. Unwin, D. O. Wipf, F. Zhou Is "proton transfer" from organic cation radicals a proton transfer or a concerted electron-H-atom transfer? J-M. Saveant Redox kinetics measured at Au electrodes derivatized with monolayers of U-hydroxythiols. C. J. Miller, A. M. Becka Molecular recognition: A new function for organized monolayers on metal surfaces. R. M. Crooks, B. Johnson. L. Kepley, L.Sun Electrochemistry at single-molecule gate sites. Design of bifunctional LangmuirBlodgett monolayers: A step toward molecular recognition in electrode reactions. M. Majda, R. Bilewicz. T. Hanna. T. Sawaguchi

WEDNESDAY MORNING Sheraton Palace Sea Cliff, Second Floor


Laser-Material Interactions: Fundamentals and Applications—III R. E. Russo, Presiding 9:00

9:40 10:30

Use of laser ionization and laser desorption/photoionization in TOFMS. F. Radicati de Brozolo Laser ablation from microparticles in an ion trap mass spectrometer. J. M. Ramsey, J. M. Dale, W. B. Whitten Study of transport efficiency of laser ablation sampling systems. J. F. Tyson, S. A. Darke



Fractionation and matrix effects in laser ablation sample introduction for elemental analysis. E. F. Cromwell, P. Arrowsmith Nanosecond versus picosecond laser ablation tor chemical analysis using ICP-AES. R. E. Russo, W-T. Chan, X. L. Mao SECTION Β


3:20 4:10


Sheraton Palace Pacific Heights, Second Floor


9:40 10:30 11:10 11:50


Use of tryptic mapping to characterize rDNA-derived protein pharmaceuticals. W. S. Hancock, R. Chloupek, J. Battersby, A. Guzzetta Use of capillary electrophoresis for peptide mapping of proteins. E. Rickard, M. Strohl Optimization of peptide mapping via computer simulations. L. R. Snyder Use of UV spectral information in the evaluation and interpretation of tryptic maps. H.J.P. Sievert Packed capillary HPLC/electrospray ionization MS of peptides and proteins. J. T. Stults, J. H. Bourell, W. J. Henzel, B. L. Gillece-Castro, L. M. Nuwaysir

Chemical Diagnostics for Chemical and Materials Science S y n t h e s i s Processes—I

9:40 10:30

11:00 11:30


Surface characterization used to ensure reliable gate oxide growth for silicon IC devices. A. Diebold Optical diagnostics of chemical vapor deposition. P. Ho, W. G. Breiland, R. J. Buss Diode laser absorption spectroscopy for process diagnostics. D. S. Bomse, D. C. Hovde, D. B. Oh, J. A. Silver, A. Stanton Development of rigorous analytical methodology for the characterization of structural ceramics. S. Natansohn Diagnostics for dc arc-jet synthesis of diamond film. R. L. Woodin, P. Spiberg, S. M. Jaffee



Sheraton Palace Sea Cliff, Second Floor A d v a n c e s in t h e Characterization of Proteins b y T r y p t i c M a p p i n g — I I Cosponsored by Subdivision of Chromatography & Separations Chemistry C. Horvath, 2:00

10:30 10:55


Chemical D i a g n o s t i c s f o r Chemical a n d Materials Science S y n t h e s i s Processes—II N. S. Nogar, Organizer, 2:00 2:40 3:25 3:55

SECTION C Sheraton Palace Sonoma, Second Floor

N. S. Nogar, Organizer,


Sheraton Palace Pacific Heights, Second Floor





A d v a n c e s in t h e Characterization of Proteins b y T r y p t i c M a p p i n g — I Cosponsored by Subdivision of Chromatography & Separations Chemistry W. S. Hancock, Organizer,

Identification of co-and post-translational modifications of eukaryotic and prokaryotic proteins. J. A. Smith Mass spectrometric approaches for peptide mapping. R. M. Caprioli Capillary electrophoresis/MS in peptide mapping. R. D. Smith, J. H. Wahl, D. R. Goodlett, H. R. Udseth, C. J. Barinaga Use of electrospray MS with LC. J. Henion, J. C. Conboy


High-resolution protein HPLC: Reversed-phase chromatography with micropellicular sorbents. K. Kalghatgi, C. Horvath


Biosensors based on ultrathin film composite membranes. C. R. Martin, B. Ballarin, D. R. Lawson Optical sensor for high-acidity measurements. B. S. Jorgensen, H. L. Nekimken Multivariate statistical process control approach to process diagnostics. Β. Μ. Wise Synthesis and characterization of covalently bonded, self-assembled monolayers on oxide surfaces for chemical sensors. D-Q. Li, B. I. Swanson Chemical process diagnostics using remote Raman spectroscopy. S. M. Angel, T. M. Vess, T. J. Kulp

SECTION C Marriott Golden Gate Β-3, Golden Gate Level

Elucidation of the mechanism of underpotential deposition of Bi(lll) with EQCM technique. M. Hepel, S. Bruckenstein, K. Kanige Dynamic film rigidity measurements on electroactive polymer films. A. R. Hillman, A. Glidle, S. Bruckenstein Sensing transition behaviors in polymer thin films on flexural plate wave devices. J. W. Grate, S. W. Wenzel, R. M. White Ion transport in electroactive bilayers. A. R. Hillman, A. Glidle Importance of polymer relaxation phenomena on the response of the electrochemical quartz microbalance. S. Bruckenstein, A. R. Hillman SECTION Β

Hilton Teakwood, Fourth Floor Separation Science A w a r d S y m p o s i u m H o n o r i n g M. V. N o v o t n y Cosponsored with Division of Industrial & Engineering Chemistry, Inc. J. W. Jorgenson, Organizer, 9:00 9:30 10:00 10:30



Tunable chromatography. S. V. Olesik, I. Souvignet Multidimensional separations using microcolumn LC. H. J. Cortes LC/MS using slurry-packed capillary columns. K-E. Karlsson Effect of phase behavior on supercritical fluid chromatography with organic and inorganic modifiers. M. L. Lee, S. H. Page, R. A. Brown, S. R. Goates Award Address. Analytical separation science in our changing world. M. V. Novotny


B i o t e c h n o l o g y a n d the H u m a n G e n o m e Project Cosponsored by Biotechnology Secretariat and Division of Chemical Health and Safety A. V. Carrano, J. S. Wassom, P. Y. Lu, Organizers A. V. Carrano, Presiding 1:30 1:45 2:30 3:30 4:15

Introductory Remarks. Physical maps: Creating a resource for the future. A. V. Carrano Virtuous data management in the human genome initiative. E. Branscomb, T. Slezak Detection of DNA sequences with chemiluminescence. I. Bronstein, C. Martin High-speed DNA sequencing in ultrathin gels. L. M. Smith

THURSDAY MORNING Sheraton Palace Sea Cliff, Second Floor


New A n a l y t i c a l A p p l i c a t i o n s of Piezoelectric S e n s o r s — I S. Bruckenstein, Organizer D. A. Buttry, Presiding 8:55 9:00

Sheraton Palace Sea Cliff, Second Floor New A n a l y t i c a l A p p l i c a t i o n s of Piezoelectric S e n s o r s — I I M. Hepel, Presiding 2:00


2:50 3:30



Selective measurement of ppb concentrations of 1,3-butadiene with a coated SAW sensor. G-Z. Zhang, Ε. Τ. Zellers Selectivity in detection of analytes in flowing streams using piezoelectric quartz. M. R. Anderson, J. A. Roush, D. Thacker Quantitative response of piezoelectric crystals in liquids. V. L. Pate, D. W. Paul Instrumentation for measuring double-layer capacitance and solution resistance at a QCM electrode. D. W. Paul, T. L. Beeler, S. R. Clark Observation of molecular monolayer dynamics on gold substrates by double-layer capacitance and acoustic shear measurements. S. R. Clark, D. W. Paul Uranyl sensor based on polymer-bound dithiocarbamate ligands on the QCM. D. A. Buttry, Y. Qiu

Introductory Remarks. S. Bruckenstein EQCM studies of ion and neutral molecule adsorption at noble metal electrodes. C. P. Wilde, M. Zhang, T. Ding

ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992 · 393 A

MEETINGS 41. 42.

43. 44. 45. 46. 47. 48.

Protein tertiary structure prediction by a neural network. J. Vanhala, E. Clementi Alternative architectures of neural networks applied to multispectral data interpretation. M. S. Madison, M. E. Munk, E. W. Robb Neural network simulations of chemical systems. S. A. Meyer, D. W. Noid, B. G. Sumpter. J. A. Darsey Neural network methods in the prediction of protein structural class. B. A. Metfessel, P. N. Saurugger Development of a neural network for a QSAR problem. A. S. Hussain, R. D. Johnson Estimation of physical-chemical properties using a neural network. M. Whitbeck Applying neural networks to the prediction of the solubilities of ionic salts. J. A. Burns, G. M. Whitesides Designer network: An attack on the force-field parameter estimation problem. A. Bergman, E. G. Zoebisch SECTION A

FRIDAY MORNING Sheraton Palace Sea Cliff. Second Floor



Sheraton Palace Pacific Heights, Second Floor Supramolecular A s s e m b l i e s on Surfaces—I M. J. Wirth, Organizer. 2:00 2:40





Atomic force microscopy studies of molecular films. R. W. Murray, C. A. Goss. J. C. Brumfield, E. A. Irene Scanning tunneling microscopy and atomic force microscopy of n-alkanethiolate monolayers spontaneously adsorbed at gold surfaces. M. D. Porter, C. A. Alves. C. A. Widrig, E. L. Smith Molecular architecture of polymers spontaneously chemisorbed on metallic surfaces from solution. J. F. Rabolt, T. J. Lenk, V. M. Hallmark. L. Haeussling, H. Ringsdorf Advances in quantitative characterization of self-assembled films by IR spectroscopy: Applications to structural correlations in diverse assembly systems. D. L. Allara, A. N. Parikh. S. V. Atre. C. W. Sheen

Separation Science A w a r d S y m p o s i u m H o n o r i n g M. V. Novotny Cosponsored with Division of Industrial & Engineering Chemistry, Inc. S. A. Cram, Presiding

2:00 2:30

Understanding chromatographic processes at the molecular level. V. L. McGuffin Immunospecific detection system for LC. F. E. Régnier, Ν. Afeyan, Ν. Gordon, S. Fulton Characterization of peptides and proteins by capillary electrophoresis. J. Frenz, S-L. Wu, W.S.Hancock

1992 Field a n d Franklin A w a r d for O u t s t a n d i n g A c h i e v e m e n t in Mass S p e c t r o m e t r y H o n o r i n g B. M u n s o n J. H. Futrell, D. P. Ridge, J. H. Futrell, Presiding 9:10 9:45


Moscone Center Room 2 2 0 - 2 2 2 , Mezzanine Level Chemical A p p l i c a t i o n s of Neural Networks Sponsored by Division of Computers Chemistry G. M. Maggiora, 2:00 3:15 4:00

SECTION C Hilton Teakwood, Fourth Floor


Analysis of components in a single cell using capillary zone electrophoresis. R. N. Zare, J. B. Shear, H. A. Fishman, R. H. Scheller Capillary LC and ultramicroanalysis. J. W. Jorgenson, R T. Kennedy. B. R. Cooper, J. A. Jankowski, E. L. Ciolkowski, R. M. Wightman



Neural networks as a tool for multispectral data interpretation. M. E. Munk, M. S. Madison. E. W. Robb Simulation of carbon-13 NMR spectra by artificial neural networks. P. C. Jurs, L. S. Anker Neural networks as function mapping devices for relating chemical structure to chemical properties and biological activities. D. W. Elrod, G. M. Maggiora, R. G. Trenary

11:05 11:40

Poster S e s s i o n : Chemical A p p l i c a t i o n s of Neural Networks Sponsored by Division of Computers in Chemistry


S u p r a m o l e c u l a r A s s e m b l i e s on Surfaces—II R. M. Corn, Presiding



D. W. Elrod, Presiding 5:00-7:00 39. 40.

Use of neural networks for variable selection in QSAR. E. R. Dow, J. H. Wikel "RNNN": A program for modeling of reaction networks. E. E. Pichler

394 A · ANALYTICAL CHEMISTRY, VOL. 64, NO. 6, MARCH 15, 1992

FT-MS studies of intermediates important in biological systems. D. P. Ridge, R. Kinser, H. L. Chen Photoionization with coherent vacuum -UV radiation. M. V. Johnston Molecular beam studies of the mechanism of collisional activation and dissociation of polyatomic ions at low and intermediate collision energy. J. H. Futrell, A. K. Shukla. K. Norbash. R. Zhao, Y. B. Chen, T. Zhang Award Address. CIMS: Chemistry in MS, from fundamentals to applications and back again. B. Munson Proton affinities of u.U-dialcohols. G. R. Nicol, P. Kebarle

Sheraton Palace Pacific Heights, Second Floor

9:00 THURSDAY EVENING Moscone Center Room 238, Mezzanine Level



Molecular adsorption and orientation at surfaces as studied by second harmonic generation. R. M. Corn Polar orientation of organic dye molecules by inorganic zirconiumphosphate interlayers. C.E.D. Chidsey, T. M. Putvinski, H. E. Katz, M. L. Schilling, W. L. Wilson, G. Scheller Orientational ordering in monolayer and multilayer assemblies of fluohnated amphiphilic polymers. H. Hsiung, R. Beckerbauer, W. Tarn, J. M. Rodriguez-Parada Molecular reorientation of adsorbates in self-assembled monolayer films. M. J. Wirth, M. E. Montgomery, J. D. Burbage