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(19) Moncada, S.; Palmer, R.M.J.; Higgs,. E. A. Pharm. Rev. 1991, 43, 109-42. (20) Iyengar, R.; Stuehr, D. J.; Marietta,. M. A. Proc. Natl. Acad. Sci,...
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(19) Moncada, S.; Palmer, R.M.J.; Higgs, Ε. A. Pharm. Rev. 1991, 43, 109-42. (20) Iyengar, R.; Stuehr, D. J.; Marietta, M. A. Proc. Natl. Acad. Set. USA 1987, 84, 6369-73. (21) Palmer, R.M.J.; Ashton, D. S.; Mon­ cada, S. Nature 1988, 333, 664-66. (22) Marietta, Μ. Α.; Yoon, P. S.; Iyengar, R.; Leaf, C. D.; Wishnok, J. S. Biochemis­ try 1988, 27, 8706-11. (23) Lewis, R. S.; Deen, W. M.; Tannenbaum, S. R.; Wishnok, J. S. /. Biol. Mass Spectrom., in press. (24) Malinski, T.; Taha, Z. Nature 1992, 358, 676-78. (25) Osterman-Golkar, S.; Ehrenberg, L.; Segerbâck, D.; Hallstrom, I. Mutat. Res. 1976, 34, 1-10. (26) Umemoto, Α.; Monden, Y.; Grivas, S.; Yamashita, K.; Sugimura, T. Carcino­ genesis 1992, 13, 1025-30. (27) Talaska, G.; Schamer, M.; Skipper, P.; Tannenbaum, S. R.; Caporaso, N.; Unruh, L.; Kadlubar, F. F.; Bartsch, H.; Malaveille, C ; Vineis, P. Cancer Epidemi­ ology, Biomarkers, and Prevention 1991, 1, 61-66. (28) Stillwell, W. G.; Bryant, M. S.; Wish­ nok, J. S. Biomed. Environ. Mass Spectrom. 1987, 14, 221-27. (29) Kadlubar, F. F.; Dooley, K. L.; Teitel, C. H.; Roberts, D. W.; Benson, R. W.; Butler, Μ. Α.; Bailey, J. R.; Young, J. F.; Skipper, P. L.; Tannenbaum, S. R. Can­ cer Res. 1991, 51, 4371-77. (30) Skipper, P. L.; Tannenbaum, S. R. Environ. Health Perspect., in press. (31) Carmella, S. G ; Hecht, S. S. Cancer

Res. 1987, 47, 2626-30. (32) Osborne, M. R.; Crosby, Ν. Τ. In Cambridge Monographs on Cancer Research: Benzopyrenes; Osborne, M.R.; Crosby, N.T., Eds.; Cambridge University Press: New York, 1987. (33) Day, B. W.; Naylor, S.; Gan, L-S.; Sahali, Y.; Nguyen, T. T.; Skipper, P. L.; Wishnok, J. S.; Tannenbaum, S. R. /. Chromatogr. Biomed. Appl. 1991, 562, 563-71. (34) Day, B. W.; Taghizadeh, K.; Skipper, P. L.; Wishnok, J. S.; T a n n e n b a u m , S. R.; Caporaso, Ν. Ε.; Vineis, P. Proceed­ ings of the AACR Meeting; American Assn. for Cancer Research: Houston, 1991. (35) Day, B. W.; Skipper, P. L.; Wishnok, J. S.; Coghlin, J.; H a m m o n d , S. K.; Gann, P.; Tannenbaum, S. R. Chem. Res. Toxicol. 1990, 3, 3 4 0 - 4 3 . (36) Beach, A. C ; Gupta, R. C. Carcinogen­ esis 1992, 13, 1053-74. (37) Shuker, D.E.G.; Farmer, P. B. Chem. Res. Toxicol. 1992, 50, 450-60. (38) Shuker, D.E.G.; Bailey, E.; Parry, Α.; Lamb, J.; Farmer, P. B. Carcinogenesis 1987, 8, 959-62. (39) Skipper, P. L.; Naylor, S.; Gan, L-S.; Day, B. W.; Pastorelli, R.; Tannenbaum, S. R. Chem. Res. Toxicol. 1989, 2, 2 8 0 - 8 1 . (40) Abdel-Baky, S.; Giese, R. W. Anal. Chem. 1991, 63, 2986-89. (41) Dull, B. J.; Hotchkiss, J. H. Toxicol. Lett. 1984, 23, 79-89. (42) Hecht, S. S.; Morrison, J. B. Cancer Res. 1984, 44, 2873-77. (43) Wishnok, J. S.; Marietta, Μ. Α., un­ published work.

(44) Wishnok, J. S.; Rait, D.; Tannen­ baum, S. R., unpublished work. (45) Day, B. W.; Gan, L-S.; Sahali, Y.; Nguyen, T. T.; Skipper, P. L.; Wishnok, J. S.; Tannenbaum, S. R. Cancer Res. 1990, 50, 4611-18. 80, 248-59.

John S. Wishnok is a principal research scientist and director of mass spectrometry at the Massachusetts Institute of Technolo­ gy's Division of Toxicology. Wishnok re­ ceived a B.A. degree in chemistry from the College of Wooster (Ohio) and earned an M.A.T. degree and a Ph.D. in chemistry from Brown University. He then spent two years as a postdoctoral fellow with Paul Schleyer at Princeton University, after which he taught organic chemistry at Bos­ ton University for four years. He has been at MIT since 1974.

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