5-Substituted-pyrrolidinyl-2-carbonyl

Xinping Lu, Marvin C. Gershengorn, and. Rahul Jain*: Thyrotropin-Releasing Hormone (TRH) Ana- logues That Exhibit Selectivity to TRH Receptor Subt...
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J. Med. Chem. 2006, 49, 5387

Additions and Corrections 2005, Volume 48 Navneet Kaur, Xinping Lu, Marvin C. Gershengorn, and Rahul Jain*: Thyrotropin-Releasing Hormone (TRH) Analogues That Exhibit Selectivity to TRH Receptor Subtype 2. Pages 6162 and 6165. The following reference should be added to the manuscript as ref 26 on page 6165: Kelly, J. A. Thyrotropin-releasing hormone: basis and potential for its therapeutic use. Essays Biochem. 1995, 30, 133-149. This new reference should be cited on page 6162 after the sentence in paragraph 1, line 29, as follows: “These CNS-mediated effects provide the rationale for the use of TRH in the treatment of brain and spinal injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND).26 ” JM060801Y 10.1021/jm060801y Published on Web 07/25/2006

2006, Volume 49 Zhonghua Pei,* Xiaofeng Li, Kenton Longenecker, Thomas W. von Geldern, Paul E. Wiedeman, Thomas H. Lubben, Bradley A. Zinker, Kent Stewart, Stephen J. Ballaron, Michael A. Stashko, Amanda K. Mika, David W. A. Beno, Michelle Long, Heidi Wells, Anita J. Kempf-Grote, David J. Madar, Todd S. McDermott, Lakshmi Bhagavatula, Michael G. Fickes, Daisy Pireh, Larry R. Solomon, Marc R. Lake, Rohinton Edalji, Elizabeth H. Fry, Hing L. Sham, and James M. Trevillyan: Discovery, Structure-Activity Relationship, and Pharmacological Evaluation of (5-Substitutedpyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors. Page 3521. In Results and Discussion, the last line in the right column is missing the words “then the C5-position” before “... of the P2 pyrrolidine ring ...”. With the added words, the correct sentence is “Alternatively, upon analyzing the structures of more potent inhibitors, cyanopyrrolidine 2 (Chart 1) and compound 10a, it occurred to us that if the P2 pyrrolidine moiety of compound 10a could serve as a rigidified linker to replace the flexible aminino side chain of cyanopyrrolidine 2, then the C5-position of the P2 pyrrolidine ring could be modified to improve potency and other properties.” JM060818G 10.1021/jm060818g Published on Web 07/27/2006

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