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Ultrasmall-Superbright NeodymiumUpconversion Nanoparticles via Energy Migration Manipulation and Lattice Modification: 808 nm-Activated Drug Release Yan Zhang,†,‡,# Zhongzheng Yu,‡,# Jingqiu Li,† Yanxiao Ao,† Jingwen Xue,‡ Zhiping Zeng,‡ Xiangliang Yang,† and Timothy Thatt Yang Tan*,‡ †
National Engineering Research Centre for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074, P. R. China ‡ School of Chemical and Biomedical Engineering, Nanyang Technological University, 637459, Singapore S Supporting Information *
ABSTRACT: Nd3+-sensitized upconversion nanoparticles are among the most promising emerging fluorescent nanotransducers. They are activated by 808 nm irradiation, which features merits such as limited tissue overheating and deeper penetration depth, and hence are attractive for diagnostic and therapeutic applications. Recent studies indicate that ultrasmall nanoparticles (20 nm).5−19 Ultrasmall Nd3+-sensitized nanoparticles (
