A Priori Prediction of Activity for HIV-1 Protease Inhibitors

2280

J. Med. Chem. 1996, 39, 2280

Additions and Corrections

1995, Volume 38

M. Katharine Holloway,* Jenny M. Wai, Thomas A. Halgren,* Paula M. D. Fitzgerald, Joseph P. Vacca, Bruce D. Dorsey, Rhonda B. Levin, Wayne J. Thompson, L. Jenny Chen, S. Jane deSolms, Neil Gaffin, Arun K. Ghosh, Elizabeth A. Giuliani, Samuel L. Graham, James P. Guare, Randall W. Hungate, Terry A. Lyle, William M. Sanders, Thomas J. Tucker, Mark Wiggins, Catherine M. Wiscount, Otto W. Woltersdorf, Steven D. Young, Paul L. Darke, and Joan A. Zugay: A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site. Page 308. Equations 1-3 should be as follows:

native:

pIC50 ) -0.212449(Einter) - 14.2042 acetylpepstatin inhibited:

pIC50 ) -0.297752(Einter) - 31.5736 L-689,502 inhibited:

pIC50 ) -0.216295(Einter) - 22.3217 Page 309. In Table 1, the R4 substituent for compound 32 should be aromatic as shown below: HN

JM960144H S0022-2623(96)00144-6

CH3