Reilly ISONICOTINIC ACID . . . a new pyridine derivative
A new
pyridine
derivative—isonico-
t i m e a c i — h a s e n t e r e d the c o m m e r · cial f i e l d . It ιs a usefιιΙ i n t e r m e d i a t e fur the p r e p a r a t i o n of p y r i d i n e compounds having substituents in the 4 — position. Reilly 98%
2 0 ° C . ) . The pH of a saturated aque· ous solution at 20°C. is 3.6. Already an important pharmaceu· tical raw material. Reilly Isonicotinic Acid is growing in usefulness and our production is expanding, For this, and
at east
for other pyridine compounds, you
only slightly soluble
c a n — a s u s u a l — r e l y on Reilly. Let
Isonicotinic
p u r e . It
is
Acid
is
i n waler ( 0 . 5 2 grams in 1 0 0 grams at
us know your requirements.
A Progress Report on ISONICOTINIC ACID Since we announced the availability of Isonicotinic Acid, it has been incorporated in several new drugs being evaluated in the treatment of tuberculosis and peptic ulcers. Preliminary results with these drugs have been so encouraging that our announcement of the first commercial availability of lsonicotinic Acid received immediate and over whelming response from research and devel opment organizations in every part of the world. It soon became apparent that the demand would exceed our ability to produce Isonicotinic from natural isomers . . . so we started to build a plant to produce the raw material synthetically.
The material from which Isonicotinic is made, gamma picoline, is a product of our Cleveland plant. An expansion program at this plant, already under way, will insure larger supplies. First new drug to come out of research on Isonicotinic Acid was Prantal, a product of Schering Corporation, Bloomfield, New Jersey. This drug is used in the treatment of peptic ulcers. Next came the new anti tuberculosis drugs, Rimifon and Nydrazid, announced recently by Hoffman-LaRoche, Inc., Nutley, New Jersey and E. R. Squibb & Sons, New York. For coal tar chemicals, you can always rely on Reilly.
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