ACQUISITIONS Celgene buys Receptos to capture potential

Jul 20, 2015 - The key to the deal is ozanimod, a sphingosine-1-phosphate receptor 1 (S1P1) agonist in Phase III studies as a treatment for ulcerative...
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NEWS OF THE WEEK

WORKER PROTECTION: Federal inspectors levy additional fines for ‘failed safety program’ at Texas facility

D

UPONT WAS SLAPPED with an additional

$273,000 penalty earlier this month for alleged safety violations at its facility in La Porte, Texas. That’s on top of fines that the Occupational Safety & Health Administration (OSHA) levied in May that stem from a November 2014 accident in which a leak of methyl mercaptan killed four workers. “These four preventable workplace deaths and the very serious hazards we uncovered at this facility are evidence of a failed safety program,” says OSHA chief David Michaels. Moreover, OSHA enrolled the Wilmington, Del.based company in its Severe Violator Enforcement Program (SVEP). This effort, according to OSHA, concentrates inspections on employers who have “demonstrated indifference towards creating a safe and healthy workplace by committing willful or repeated violations, and/or failing to abate known hazards.” DuPont says it is “disappointed with OSHA’s classification” and will confer with the agency to understand its decision. OSHA’s initial investigation identified hazards in the facility’s herbicides unit, where the accident occurred, resulting in a $99,000 fine against DuPont. Those findings prompted OSHA to expand its inspection to other parts of the plant, where the agency says it found additional worker safety violations. “I hope that our continued scrutiny into this facility

and into working conditions at other DuPont plants will mean no family ever suffers this loss again,” Michaels adds. “We here at OSHA want DuPont and the chemical industry as a whole to hear this message loud and clear.” OSHA cited DuPont for three willful violations at the La Porte plant, alleging that the company “purposefully disregarded” safety rules or “acted with plain indifference to employee safety.” The agency assessed a maximum penalty allowed by law of $70,000 for each violation. In addition, OSHA cited DuPont for four “serious” violations, which means they could have led to injury or death, and added another $28,000 in fines, again the maximum allowed by law. A repeat violation of a previous worker safety citation brought the penalty total to $273,000. Chemours, the DuPont spin-off that now owns the hydrofluoric acid unit at the La Porte site, says it was not named in the citations and is not affected by the SVEP designation. Since the accident, DuPont says it has been reexamining the safety systems at La Porte. “We have shut down the herbicide unit in order to take corrective measures, and the unit will not restart until the work is complete,” the company says. DuPont is contesting the citations that led to the initial $99,000 fine. It hasn’t said whether it will request an informal conference with OSHA to discuss the new citations and proposed penalties or contest those findings before the independent Occupational Safety & Health Review Commission.—GLENN HESS AP

DUPONT LABELED ‘SEVERE VIOLATOR’

Four workers died from exposure to methyl mercaptan during a leak at DuPont’s LaPorte, Texas, plant in November 2014.

ACQUISITIONS Celgene buys Receptos to capture potential immunology drug Looking to become a force in immunology, Celgene will pay $7.2 billion to acquire the San Diego-based biotech firm Receptos. The key to the deal is ozanimod, a sphingosine-1-phosphate receptor 1 (S1P1) agonist in Phase III studies as a treatment for ulcerative colitis and multiple sclerosis (MS). Although Novartis’s S1P1 modulator Gilenya has been available to treat MS since 2010, Celgene is convinced that ozanimod is a better molecule. In addition to S1P1, Gilenya hits other members of the sphingosine-1-phosphate receptor family. Ozanimod, which was discovered at Scripps Research Institute,

California, is highly selective, notably ecule could shine in ulcerative colitis. avoiding the S1P3 subtype, which is asso“Should ozanimod achieve anything ciated with a risky drop in like Celgene’s estimated $4–6 billion in N heart rate. peak sales, the acquisition price would O Celgene won’t know unseem a steal to us,” he writes in a note to til 2017, when results from investors. the Phase III study emerge, Ozanimod adds to Celgene immunolwhether its bet on ozanimod ogy assets, which include the oral anO will pay off. But the company is tisense drug candidate GED-301 and N N projecting the molecule will generthe already-approved PDE4 inhibiate peak annual sales of $4 billion to tor Otezla. With that trio, Celgene $6 billion. thinks it can penetrate nearly Cowen & Co. stock analyst Eric all of the immunology market, HN Schmidt calls the difference between which it expects to be Gilenya and ozanimod “debatable” OH worth close to $100 billion Ozanimod but notes that the Receptos molin 2020.—LISA JARVIS

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JULY 20, 2015