Allosteric Control of Acetylcholinesterase Activity by Monoclonal

The numbers for kon reported in Table 1 are incorrect. The table should appear as follows: BI9950948. 10.1021/bi9950948. Published on Web 11/03/1999...
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15688

Biochemistry 1999, 38, 15688

Corrections Allosteric Control of Acetylcholinesterase Activity by Monoclonal Antibodies, by Ashima Saxena,* Regina Hur, and B. P. Doctor, Volume 37, Number 1, January 6, 1998, pages 145-154. Page 148. The numbers for kon reported in Table 1 are incorrect. The table should appear as follows: Table 1: Competition of Ligands with MAbs for Binding to FBS AChEa kon × 10-9 (M-1 min-1) competing ligand

4E5

25B1

13D8

5E8

6H9

2A1

none edrophonium propidium

0.17 ( 0.01 0.12 ( 0.01 0.06 ( 0.01

0.17 ( 0.01 0.14 ( 0.01 0.01 ( 0.001

0.011 ( 0.001 0.012 ( 0.001 0.006 ( 0.001

1.20 ( 0.1 1.20 ( 0.1 0.24 ( 0.1

0.20 ( 0.01 0.20 ( 0.01 0.01 ( 0.001

0.20 ( 0.01 0.18 ( 0.01 0.08 ( 0.01

a Values of kon for the interaction of MAbs with AChE were determined by analyzing the time course of inhibition reactions using a nonlinear fit of the data to eq 2, in the absence or presence of the indicated ligands shown in Figure 1.

BI9950948 10.1021/bi9950948 Published on Web 11/03/1999