Amyloid Fibril Nucleation: Effect of Amino Acid Hydrophobicity

Addition/Correction pubs.acs.org/JPCB

Correction to “Amyloid Fibril Nucleation: Effect of Amino Acid Hydrophobicity” Stefan Auer* J. Phys. Chem. B 2014, 118, (20), 5289−5299. DOI: 10.1021/jp411370y he coefficient A2 in eq 38 was given incorrectly in one case. The corresponding two sentences should read as follows: Similarly, we obtain the formula for J in the nucleation regime when the fibril nuclei are composed of an odd number (i) of β-sheets plus one β-strand (i = 1, 3, 5, ...; Cee2ψw/(i+1) < C1 < Cee(ψw+ψs)/i or Cee2ψs/(i+1) < C1 < Cee(ψw+ψs)/i):

T

J = A1C1i + 2

1 − A 2 C1−1 (1 − A3C1i)2

(38)

−2ψi−ψw+ψs Here A1 = (2ke/Ci+1 and A2 = Cee2ψw/(i+1) or A1 = e )e i+1 −2ψi−ψs+ψw 2ψs/(i+1) (2ke/Ce )e and A2 = Cee when the β strand is on −(ψw+ψw) the nucleus SH or WH side, respectively, and A3 = C−i e e

in both cases.

Published: January 15, 2015 © 2015 American Chemical Society

1785

DOI: 10.1021/acs.jpcb.5b00251 J. Phys. Chem. B 2015, 119, 1785−1785