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Anti-cataractogenesis Mechanisms of Curcumin and a Comparison of its Degradation Products: an In Vitro Study Jiahn-Haur Liao, Yi-Shiang Huang, Yu-Ching Lin, Fu-Yung Huang, Shih-Hsiung Wu, and Tzu-Hua Wu J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.6b00430 • Publication Date (Web): 23 Feb 2016 Downloaded from http://pubs.acs.org on February 28, 2016
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Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
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Journal of Agricultural and Food Chemistry
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Anti-cataractogenesis Mechanisms of Curcumin and a
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Comparison of its Degradation Products: an In Vitro Study
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Jiahn-Haur Liaoa, Ψ, Yi-Shiang Huanga, c, Ψ, Yu-Ching Lina, Fu-Yung Huangb
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, Shih-Hsiung Wua, , and Tzu-Hua Wuc, ＊
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a
Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.
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b
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
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c
Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei
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Medical University, Taipei 110, Taiwan
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Short title:
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Comparative effects of curcumin and its degradation products on lens proteins
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Ψ
Equal contribution to this work.
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To whom correspondence should be addressed: Shih-Hsiung Wu, PhD, Tel: 8862
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2785 5696, Ext. 7101; Fax: 8862 2653 9142, E-mail:
[email protected];
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Tzu-Hua Wu, PhD, Tel.: 8862 2736 1661 ext. 6172; Fax: 8862-2735-8920, E-mail:
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[email protected] 24 1
ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
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Abstract
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Curcumin (Cur) exhibits anti-cataractogenesis activity. This study aimed to compare
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the activities of Cur with those of its degradation products in a series of in vitro lens
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protein turbidity assays. The results show that Cur (200 µM) ameliorates
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selenite-induced crystallin aggregation, and the mean O.D. value was 0.10± 0.02
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(p
