An Isotope-Coded Photocleavable Probe for Quantitative Profiling of

2 days ago - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850 , China.

Jan 8, 2019 - Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems. Journal of the American ...

Jan 8, 2019 - O-linked N-acetylglucosamine (O-GlcNAc) is a ubiquitous post-translational modification of proteins and is essential for cell function.

Jan 8, 2019 - We demonstrate the application of the probe to quantitatively profile ... Thus, this probe provides a powerful tool to profile O-GlcNAcylation dynamics in cells. .... industry last year brought one particularly high price tag: Takeda.

4 days ago - Browne, Jiang, Ficarro, Doctor, Johnson, Card, Sivakumaren, Alexander, Yaron, Murphy, Kwiatkowski, Zhang, Cantley, Gray, and Marto.

Jan 8, 2019 - Department of Chemistry, University of South Carolina−Lancaster, ..... Dillon, M. B., Bachovchin, D. A., Mowen, K., Baker, D., and Cravatt,.

Jan 8, 2019 - Linda C. Hsieh-Wilson,. ∞ ... State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing ..... (30) Khidekel, N., Ficarro, S. B., Clark, P. M., Bryan, M. C., Swaney,.

Jul 10, 2013 - By taking advantage of the quantitative capability of this isotope-coded probe, we devised an affinity profiling strategy to comprehensively ...

Jul 10, 2013 - On the basis of our quantitative proteomic results, we deduce that K356 may represent the other ATP-binding site located in the C-terminal domain of HSP90. This notion is further .... Therefore, ICAP holds great potential in quantitati

Nov 1, 2008 - BPyneTEA concentration-dependent decrease of the fastest closed time component and ... free of charge via the Internet at https://pubs.acs.org.