Angiotensin-converting enzyme inhibitors - American Chemical Society


Apr 9, 1984 - giotensin-converting enzyme, Among these are enalapril. (MK-421) and its parent diacid enalaprilat (MK-422)1 as well as lactam inhibitor...
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Results and Discussion. The compounds were tested for in vitro inhibition of. ACE, and the results also appear in Table I. Although the free diacids are required ...

Derivatives. Norbert Gruenfeld, James L. Stanton,* Andrew M. Yuan, Frank H. Ebetino, Leslie J. Browne, Candido Gude, and Charles F. Huebner. Research and ...

Jeffrey N. Barton,' Bernard Loev,'. Howard Jones,+ Edward S. Neiss,+ Alfred Schwab,* William S. Mann,§ Atul Khandwala,f Peter S. Wolf,§ and Ira Weinrybt.

Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Revlon Health Care Group, Tuckahoe,. New York 10707. Received May 10, 1984.

Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Revlon Health Care Group, Tuckahoe,. New York 10707. Received May 10, 1984.

The synthesis and biological activity of a series of inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) are described. Incorporation of the substituted ...

Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Revlon Health Care Group, Tuckahoe,. New York 10707. Received May 10, 1984.

Jan 7, 1985 - C02H 0. 1 .N-. C02H. 0. R1. NH. CH2CH2CkH= A. ^^co2r2. 2: R'=CH3, R2 = C2H5 ... pounds has led to the discovery of l-benzazepin-2-one derivative 4 ... 1984, 53, ..... kins, D. Miller, and R. A. Dotson for the in vivo biological.

10 May 1984 - Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Revlon Health Care Group, Tuckahoe,. New York 10707. Received ...

Jan 7, 1985 - Compound 5a was especially potent when tested in dogs for inhibition of angiotensin I ... with 1 or 2 equiv of sodium hydroxide led to acidesters.