ANTIBODY- DRUG CONJUGATES

Jan 20, 2014 - “In all honesty,. I decided to be a chemist right after I found out. I couldn't be a cowboy.” MELISSA A. HINES, 2014. RECIPIENT, AR...
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VOLUME 92, NUMBER 3 JANUARY 20, 2014

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COVER STORY

C&EN charts one university’s long, complex trek to viable drug candidates.

ANTIBODYDRUG CONJUGATES

GOVERNMENT & POLICY 30 31

SCIENCE & TECHNOLOGY 33 36

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MELISSA A. HINES, 2014 RECIPIENT, ARTHUR W. ADAMSON AWARD FOR DISTINGUISHED SERVICE IN THE ADVANCEMENT OF SURFACE CHEMISTRY PAGE 45

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NEWS OF THE WEEK 7

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Leak of coal-processing fluid highlights dearth of toxicity data. HOLD THE PHONE ON KiOR BIOFUELS

Great publicity can’t prevent a closure to improve the firm’s technology and seek more capital.

CONCENTRATES ACYL CARRIER PROTEINS REVEALED

Two studies elucidate the workings of a crucial class of biosynthesis mediators. NEW ACTIVITY FOR OLD DRUG ▶

Researchers propose mechanisms for a lymphoma drug’s possible anti-Alzheimer’s activity.

CHEMICAL SPILL IN WEST VIRGINIA

EDUCATION 40

PRECEPTORS TAKE ON A UNIQUE ROLE



University of Delaware experiments with scientists teaching interdisciplinary classes.

MONSANTO PATENT RIGHTS PREVAIL

High court rejects a case brought against firm by farmers who fear lawsuits from accidental contamination. TRANSFORM THAT ALKENE

New reduction and direct coupling both start with the ubiquitous compound class. SHALE GAS WELCOMED IN THE U.K.

Industry support, economic benefits pave the way for development ahead of the rest of Europe. STUDYING PROTEIN VARIATION

Technique uses antibodies, pieces of DNA to detect hundreds of different proteins on cells. AT LAST, A 2014 FEDERAL BUDGET

Congress finally passes a budget, and it includes increases for R&D agencies. RNA-BASED DRUGS OUT OF THE GATE

ACS NATIONAL AWARDS 43

Small companies with promising therapeutics are attracting eager partners, building momentum.

247TH ACS NATIONAL MEETING 49

Under a controversial patent system, India makes a major portion of the world’s generic drug supply.

PRELIMINARY PROGRAM

List of technical symposia and general meeting information for Dallas, March 16–20.

BUSINESS CONCENTRATES INDIA, THE WORLD’S DRUGSTORE

2014 WINNERS

Armstrong, Curran, Hines, Lester, and Sneddon.

IMPROVING REPRODUCIBILITY

Several groups want standards for the life sciences that would cement research milestones. 23 25

CONCENTRATES POLYSTYRENE KICKED TO THE CURB

Trend of banning food and beverage containers made with the plastic foam spreads among cities.

As more and more of these treatments enter clinical trials, members of the supply chain ramp up to meet demand.

QUOTE OF THE WEEK “In all honesty, I decided to be a chemist right after I found out I couldn’t be a cowboy.”

ACADEMIA’S HUNT FOR DRUGS

THE DEPARTMENTS 3 4

EDITOR’S PAGE LETTERS

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CLASSIFIEDS NEWSCRIPTS

COVER: An SAFC worker handles materials for the manufacture of antibody-drug conjugates. SAFC

C E NE AR 92 ( 3) 1 –8 8 • ISSN 0009 - 2 347