Serving the chemical, life sciences, and laboratory worlds
VOLUME 92, NUMBER 3 JANUARY 20, 2014
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COVER STORY
C&EN charts one university’s long, complex trek to viable drug candidates.
ANTIBODYDRUG CONJUGATES
GOVERNMENT & POLICY 30 31
SCIENCE & TECHNOLOGY 33 36
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MELISSA A. HINES, 2014 RECIPIENT, ARTHUR W. ADAMSON AWARD FOR DISTINGUISHED SERVICE IN THE ADVANCEMENT OF SURFACE CHEMISTRY PAGE 45
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NEWS OF THE WEEK 7
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Leak of coal-processing fluid highlights dearth of toxicity data. HOLD THE PHONE ON KiOR BIOFUELS
Great publicity can’t prevent a closure to improve the firm’s technology and seek more capital.
CONCENTRATES ACYL CARRIER PROTEINS REVEALED
Two studies elucidate the workings of a crucial class of biosynthesis mediators. NEW ACTIVITY FOR OLD DRUG ▶
Researchers propose mechanisms for a lymphoma drug’s possible anti-Alzheimer’s activity.
CHEMICAL SPILL IN WEST VIRGINIA
EDUCATION 40
PRECEPTORS TAKE ON A UNIQUE ROLE
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University of Delaware experiments with scientists teaching interdisciplinary classes.
MONSANTO PATENT RIGHTS PREVAIL
High court rejects a case brought against firm by farmers who fear lawsuits from accidental contamination. TRANSFORM THAT ALKENE
New reduction and direct coupling both start with the ubiquitous compound class. SHALE GAS WELCOMED IN THE U.K.
Industry support, economic benefits pave the way for development ahead of the rest of Europe. STUDYING PROTEIN VARIATION
Technique uses antibodies, pieces of DNA to detect hundreds of different proteins on cells. AT LAST, A 2014 FEDERAL BUDGET
Congress finally passes a budget, and it includes increases for R&D agencies. RNA-BASED DRUGS OUT OF THE GATE
ACS NATIONAL AWARDS 43
Small companies with promising therapeutics are attracting eager partners, building momentum.
247TH ACS NATIONAL MEETING 49
Under a controversial patent system, India makes a major portion of the world’s generic drug supply.
PRELIMINARY PROGRAM
List of technical symposia and general meeting information for Dallas, March 16–20.
BUSINESS CONCENTRATES INDIA, THE WORLD’S DRUGSTORE
2014 WINNERS
Armstrong, Curran, Hines, Lester, and Sneddon.
IMPROVING REPRODUCIBILITY
Several groups want standards for the life sciences that would cement research milestones. 23 25
CONCENTRATES POLYSTYRENE KICKED TO THE CURB
Trend of banning food and beverage containers made with the plastic foam spreads among cities.
As more and more of these treatments enter clinical trials, members of the supply chain ramp up to meet demand.
QUOTE OF THE WEEK “In all honesty, I decided to be a chemist right after I found out I couldn’t be a cowboy.”
ACADEMIA’S HUNT FOR DRUGS
THE DEPARTMENTS 3 4
EDITOR’S PAGE LETTERS
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CLASSIFIEDS NEWSCRIPTS
COVER: An SAFC worker handles materials for the manufacture of antibody-drug conjugates. SAFC
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