Antifungal Agents1 - Journal of the American Chemical Society (ACS

Stephen B. Coan, and Dominick Papa. J. Am. Chem. Soc. , 1955, 77 (9), pp 2402–2404. DOI: 10.1021/ja01614a013. Publication Date: May 1955. ACS Legacy...
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2402

STEPHEN B. COAN AND

was heated for 2-4 hours a t 100'. Any excess of unused amine and solvent was removed by evaporation in uucuo. The residue was basified with a small amount of cold 20% aqueous sodium hydroxide (to P H 11) and the precipitated solid bis-aminoamide was collected by suction and washed with a little cold water. The products were purified by recrystallization from ethyl acetate, hexane or mixtures of these solvents. Yields were usually above 90%.

[CONTRIBUTION FROM

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DOMINICK PAPA

Vol. 77

The bis-tertiary-aminoacetylamides were quaternized by refluxing with methyl iodide in methanol for several hours. The bis-methiodides crvstallized from meth ~ n o lor metlianol-ethyl