Antimalarial and Antischistosomal Effects of a,a,a,a',a',a'-Hevachloroxylene Ilerivatives and Related Halogenated Hydrocarbons'- '
Dcpartiiicnt o j ('hc niiaii i j , .21(rliLal and Scicnti$c d f f a i r s D w w o n , Parkc, Daeis and Company, .Inn .Irbor, .llithigan 48106
In 1960 Lammler4 reported that a ,a , a . a', a ' , &-hexitchloro-p-xylene (I)? waq active against the liver fluke Fasciola hepatica in rat71 >79
1.3 I .8 1.1
14 14
85 62
0.9 1.2
14
263
0.3
29
14
180
0.4
17 18
30 24
28
36
2.1
19 20 21 22
26,31 26,32 33 24
7
>329
354 120
Single S.C. dose AMST; T or Cc a f t e r dose320
160
80
40
