Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A

The 1H and 13C NMR, APT, 1H−1H-COSY, TOCSY (mixing time of 45 ms and ..... Pacific Invertebrates; Coral Reef Research Foundation: Beverly Hills, CA,...
0 downloads 0 Views 56KB Size
J. Med. Chem. 2004, 47, 1149-1152

1149

Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa1 George R. Pettit,*,† Jun-Ping Xu,† Jean-Charles Chapuis,† Robin K. Pettit,† Larry P. Tackett,† Dennis L. Doubek,† John N. A. Hooper,‡ and Jean M. Schmidt† Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, Arizona 85287-2404, and Sessile Marine Invertebrates, Queensland Museum, South Brisbane, Queensland 4101, Australia Received April 29, 2003

The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to