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Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression Yu-Wen Ting, Wei-Tang Chang, Duen-Kai Shiau, Pei-Hsuan Chou, Mei-Fang Wu, and Chin-Lin Hsu J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.7b03551 • Publication Date (Web): 18 Dec 2017 Downloaded from http://pubs.acs.org on December 18, 2017
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Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
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Journal of Agricultural and Food Chemistry
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Journal of Agricultural and Food Chemistry
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Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on
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Body Composition, Serum Lipid Profile, and Gene Expression
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Yuwen Tinga, Wei-Tang Changb, Duen-Kai Shiauc,d, Pei-Hsuan Choub, Mei-Fang Wuc, Chin-Lin
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Hsub,e,*
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a
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Taiwan
Graduate Institute of Food Science and Technology, National Taiwan University, Taipei,
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b
Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan
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c
Department of Industrial Engineering and Systems Management, Feng Chia University,
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Taichung, Taiwan,
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d
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and Technology, Taichung, Taiwan
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e
Department of Dental Technology and Materials Science, Central Taiwan University of Science
Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan
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* Author to whom correspondence should be addressed.
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Address: No. 110, Sec. 1, Jianguo N. Rd., Taichung City, 40201, Taiwan.
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Phone: 886-4-24730022, Fax: 886-4-23248175
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E-mail:
[email protected] 23
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Journal of Agricultural and Food Chemistry
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Abstract
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The anti-obesity effects of quercetin-rich supplement (QRS), which contain quercetin,
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lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were
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investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated
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the final body weights [490±11 (HFD)→441±11 (HFD+QRS) g], total body fat [112.9±4.5
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(HFD)→86.6±5.7 (HFD+QRS) g], liver weights [14.8±0.4 (HFD)→12.6±0.4 (HFD+QRS) g/rat],
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and the serum TG [102.5±7.3 (HFD)→90.7±6.5 (HFD+QRS) mg/dL] to a level that resembled
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the regular diet-consumed rats (p
