Arylamino alcohol antimalarials. A new method for incorporating the

XOTES

Sovember 1968

1221 SCHEME I

quinolone-2-carboxylate (4b) separated from the solvent phase (48qc) and was purified by recrystallization from pyridine, mp 292-293". The 5-chloro isomer (4c) was obtained in 15% yield by diluting the AcOH with H?O. An analytical sample, mp 2,5.5-2d7", was prepared by recrystallization from AIeOH (charcoal).

ArCOOH 3

J 1

I

ArCOCH,-ha1 6

/" \

Ar€OCH-KR2

OH

I

Ar&HCHN