ARYLSULFUR TRIFLUORIDES AND PENTAFLUORIDES - Journal of

William A. Sheppard. J. Am. Chem. Soc. , 1960, 82 (17), pp 4751–4752 ... Paul R. Savoie and John T. Welch. Chemical Reviews 2015 115 (2), 1130-1190...
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COMMUNICATIONS TO THE EDITOR

Sept. 3, 1YGO

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Spectral analyses2 indicate that secondary phosphine sulfides exist in the thiono, rather than the thiolo, form. A characteristic P-H absorption band of weak to medium intensity is exhibited in the infrared a t 2320 f 10 cm.-' (half intensity band width of 35 wave numbers) together with a CONTRIBUTION No. 2605 LAWRENCE K. MONTGOMERY GATESA N D CRELLINLABORATORIES OF CHEMISTRY P-S (CsBr disc) a t 600 cm.-' (alkyl) or 640 cm.-' CALIFORNIA INSTITUTE O F TECHNOLOGY PASADENA, CALIFORNIA JOHND. ROBERTS (aryl). Nuclear magnetic resonance spectra in the phosphorus region show a doublet centered near RECEIVED JULY21, 1960 -22 p.p.m. (relative to %yoHzP04) with an average splitting of 28 p.p.m. which is consistent with SECONDARY PHOSPHINE SULFIDES the proposed structure. Sir: Secondary phosphine sulfides have been further We wish to report the preparation of a new class characterized by base-catalyzed addition of aldeof compounds, secondary phosphine sulfides R1- hydes and ketones t o form a-hydroxy-substituted R2P(S)H (I), by the oxidation of secondary phos- tertiary phosphine sulfides (111). Typical examples phines with elemental sulfur. Oxidation of secs S ondary phosphines t o the corresponding dithiophosII II phinic acids (11) has long been known,' but the RIRzP-H RIRIC=O +RIRZP-CR~R~ addition of only one atom of sulfur to secondary I OH phosphines has not been accomplished previously.

mechanism with 1-bromoadamantane through the corresponding unsaturated compound with a double bond a t the bridgehead (in violation of Bredt's rule) have been unsuccessful. The only reaction so far observed has been halogen-metal exchange.

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S

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RlR?PH

II + 2s ---+ RIR2P-SH I1

are di-n-butyl-a-hydroxybenzylphosphinesulfide (757, yield; m.p. 54-55' from heptane; anal. Calcd. for C16H26POS: C, 63.35; H I 8.86; S, 11.27. Found: C, 63.56; H, 8.98; S, 11.49), bis- (2 - cyanoethyl) - 1-hydroxy-1-methylethylphosphine sulfide (70% yield; m.p. 113-115' from benzene; anal. Calcd. for C Q H ~ N ~ O P C, S : 46.94; H, 6.57; S, 13.93. Found: C, 46.92; H, 6.51; S, 13.88), and diphenyl-l-hydroxy-l-methylethylphosphine sulfide (7570 yield, m.p. 118-120' from benzene; anal. Calcd. for C1bHl,OPS: C, 65.19; H, 6.20; S , 11.60. Found: C, 65.11; H, 6.99; S, 11.25). I n addition, secondary phosphine sulfides can be oxidized by elemental sulfur to the corresponding dithiophosphinic acids (11). Details of this reaction and the carbonyl addition will be presented in a broader study of the chemistry of the secondary phosphine sulfides.

Successful control of the process is effected by the addition under nitrogen of one equivalent of sulfur to a solution of a secondary phosphine in an inert solvent, such as benzene 01 carbon tetrachloride. Disappearance of the sulfur signals completion of the reaction, whereupon the product is obtained in a fair state of purity by removing the solvent under reduced pressure. Further purification of liquid products by distillation is accompanied by decomposition which reduces the yield of purified material considerably. By this method there were obtained : di-n-butylphosphine (2) We are indebted t o N. B. Colthup for the infrared spectral d a t a , sulfide (100% crude yield, 36% distilled, b.p. and t o J. E. Lancaster for the n.m r. results. 122-125' (1.5 mm.); anal. Calcd. for CaHlePS: CHEMICAL RESEARCH DEPARTMENT PI 17.38; S , 17.99. Found: PI 17.69; S, 18.00), CENTRAL RESEARCH DIVISION GRACE PETERS di-isobutylphosphine sulfide (65yo yield, m.p. AMERICANCYANAMID COMPANY CONNECTICUT 61-62' from ligroin; anal. Calcd. for CsH19PS: STAMFORD, C, 53.89; H, 10.74; S, 17.99. Found: C, 53.89; RECEIVED JULY12, 1960 H, 11.06; S, 18.29), cyclohexyl-2-cyanoethylphosphine sulfide (liquid, 56% yield; anal. Calcd. for ARYLSULFUR TRIFLUORIDES AND C Q H l N " : P, 15.39; S , 15.93. Found: PI 15.42; PENTAFLUORIDES S, 16.0l), bis- (2-carbethoxyethyl) -phosphine sulfide (liquid, 82% yield; anal. Calcd. for C10H19P04S: Sir : C, 45.10; H , 7.19; P, 11.63. Found: C, 45.26; We wish to report the tirst synthesis of arylH, 7.19; P, 11.88),2,4,6-triisopropyl-3,5-dioxa-l-sulfur pentafluorides and the first general syntheses phosphacyclohexane-1-sulfide(5770 distilled yield, of arylsulfur trifluorides. b.p. 107-112O (1.5 rnm.), m.p. 37'; anal. Calcd. Perfluoroalkylsulfur trifluorides and pentafluofor C12H2&'02S: C , 54.52; H, 9.53; P, 11.72; rides are known derivatives of sulfur tetrafluoride S, 12.13. Found C, 54.03; H, 9.48; PI 11.44; and hexafluoride, respectively, prepared in general, S, 11.78), and diphenylphosphine sulfide (lOOyo by oxidative fluorination reactions. Although yield, m.p. 95-97' from acetonitrile; anal. Calcd. other sulfur hexafluoride derivatives such as S2FlO,lb for C12HllPS: C, 66.03: H , 5.08: P, 14.19; S, (1) (a) Lovelace, Rausch and Postelnek. "Aliphatic Fluorine Com14.69. Found: C, 6.5.93; H, 5.23; P, 14.47; S, pounds,'' Chapter 13, Reinhold Publishing Corp., New York. N. Y.. 14.78). 1958; (b) Special Publication No. 12, "Chemical Society Symposia, (1) A. W. Hofmann and F. Mahla, Ber., 26, 2436 (1892): L, Malatesta and R. Pizzotti. Gaee. Chim. ILA,16,167 (1946).

Bristol, 1958," T h e Chemical Society, Burlington House, W. I.,

London, 1958,p. 317-327.

COMMUNICATIOXS TO THE EDITOR

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and SF5Cl2 are known, efforts to prepare alkyl- and arylsulfur pentafluorides have been unsuccessful. 1b,3 The only alkyl- or arylsulfur trifluoride known is 2,4-dinitrophenylsulfur trifluoride, prepared by Chamberlain and Kharasch4 by the reaction of fluorine with the corresponding disulfide in anhydrous hydrogen fluoride solution. We have found that phenylsulfur trifluoride is obtained in 30 to 60c& yield by the exothermic reaction of silver difluoride with a solution of phenyl disulfide in a "Freon" solvent, 1,1,2-trichloro-1,2,2trifluoroethane. Phenylsulfur trifluoride is a color(CIHBS)? f 6AgFs +ZCJ-IjSFa 6AgF less liquid, b.p. 60' ( 5 mm.), that is hydrolyzed rapidly by water to benzenesulfinic acid and slowly attacks "Pyrex" glass. Anal. Calcd. for C6H5F3S: F, 34.3;S, 19.3. Found: F, 33.5;S, 19.9. Phenylsulfur trifluoride fluorinates carbonyl compounds : for example, benzaldehyde is converted to benzal fluoride (80y0)by being heated with phenylsulfur trifluoride for 3 minutes a t 100°.5 SFbOFIb

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other substituents. Thus, we have determined that the sulfur pentafluoride group is strongly electron-withdrawing and is meta-directing to electrophilic substitution. A detailed report of the method of synthesis and chemistry of the arylsulfur trifluorides and pentafluorides, as well as quantitative measurements on the inductive and resonance effects of the sulfur pentafluoride group, will be published i n the near future. IVe are indebted to Drs. B. C . LlcKusick and T. L. Cairns for helpful discussions and suggestions during the course of the work CONTRIBUTION 1-0 634 FROM THECENTRAL RESEARCH DEPARTMEST ~VILLIAMA. SHEPPARD EXPERIMENTAL STATION E. I. DU PONT DE SEMOCRS A N D COMPANY WILMISGTOS, DEL. RECEIVED JULY18, 1960 THE SYNTHESIS OF PHENYLATED AZIRIDINONES'

Sir:

This communication describes the preparation of a new class of cyclic amides, a-lactams, previously 0 0 postulated as an intermediate in the sodamideII ll pronioted conversion of a-chloro-a-phenylacetaniCaHsSF3 f CsHsCH +CeHsSF CtjHjCHF? lide (Ia) into a-anilinophenylacetamide' (11). Substituted arylsulfur trifluorides, XC6H4SF3, where Ia(XE","," 247-250 mp (4.19); ; :A: (cm.-l) 3306, X = NO2 or CH3, are prepared in a similar manner. 3150,1667) was caused to react with sodium hyWhen phenylsulfur trifluoride is heated gradu- dride in a manner described2 (this time with a ally to 130' with silver difluoride in a reactor made complete exclusion of oxygen from the reacting of copper or Teflon [polytetrafluoroethylene], system), giving two compounds : (1) 2,5-diketophenylsulfur pentafluoride is obtained in about 10% 1,3,4,6,-tetraphenylpiperazine( 12y0 yield), and yield. Phenylsulfur pentafluoride is a colorless (2)1,3-diphenyl-2-aziridinone, IIIa, (78-8S7cyield) C~HBSFB 2AgF2 --+ CeHsSFj + 2AgF as colorless crystals, (sintering a t 1 1 5 O ) melting liquid, b.p. 149", n Z 51.4290, ~ that is comparable a t 145-150' (dec.) (XE",","243-247 mp (4.02); in thermal and hydrolytic stability to benzotri- Xz?2'3 (cm.-') 1720, 1704, 1689; anal. found for CllHllON: C, 79.9: H , 5.6; Tu', 6.4; mol. wt., fluoride. 212 (ebullioscopic, benzene) . 3 Alkaline hydrolysis Anal. Calcd. for C6H5F5S: C, 35.3;H , 2.47; of I I I a was slow even a t 78", consuming approxiF, 46.5; S, 15.7. Found: C, 35.5; H , 2.74; mately 0.4 equivalent of alkali on being refluxed F,46.7;S,15.G. with 0.1 N ethanolic potassium hydroxide during The n.m.r. (fluorine and proton), infrared and six hours. However, ammonolysis of IIIa by ultraviolet spectra are consistent with the struc- means of sodamide in liquid ammonia provided ture C6H5SF6. The compound is hydrolyzed I1 as the only isolable product. slowly to benzenesulfonyl fluoride by heating a t A-aH 100' with 100yO sulfuric acid. m- and p-nitro- RiR?ClCCOPI" CsH 5 + -H2, -iSaCl phenylsulfur pentafluorides are also prepared (1530% yield) by heating the corresponding disulfide with silver difluoride, first in the "Freon" solvent, CCl2FCC1F2,and then a t 130" in a copper reactor I' with fittings of "Teflon." Anilines substituted C by a sulfur pentafluoride group in the meta- or para-position are prepared by catalytic hydrogenaR1\ccY-CsHi tion of the corresponding nitro derivatives, and react in the manner typical of anilines; thus, they can be acylated or diazotized. The above series of arylsulfur trifluorides and a-Chloro-a,or-diphenyla~etanilide~ (Ib, m.p. &(io, pentafluorides are unique in providing key com- AElH: 245 mp (4.24)) was brought to reaction pounds necessary for determination of the properM a y otherwise be termed or-lactams or azacyclopropanonrs. ties of the SF3and SFs groups in comparisons with the(1)above systematic name, illustrating a carbonyl containing deriva-

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( 2 ) H. L. Roberts and N. H. R a y , J . Chem. SOL..665 (1960). ( 3 ) H. J. Emeleus and H . G. Heal, ibid. 112G (1946). (4) D. L. Chamberlain and N. Kharasch, THIS J O U R N A I . , 7 7 , 1041

(1955). ( 5 ) T h e use of SA for fluorination of carbonyl compounds is described b y w. R. Hasek, w. C. Smith and V. A . Engelhardt, ibid., 82, 543 (1960).

tive of aziridine (otherwise termed ethyleneirnine) is t o be preferred. See Patterson and Capell "The Ring Index," Reinhold Publishing Corp., New York, N. Y., 1940. (2) S Sarel and A. Greenberger, J . Oug. Chem., 23,330 (1958). (3) Measurements were taken with a Gallenkamp semimicro ehuliometer, No. 7665K. (4) H. Klinger, A f z n . , 389, 253 (1912).