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Ecotoxicology and Human Environmental Health
Association of Exposure to Ambient Fine Particulate Matter Constituents With Semen Quality Among Men Attending a Fertility Center in China Xiji Huang, Bing Zhang, Li Wu, Yun Zhou, Yonggang Li, Xiang Mao, Ying Chen, Jing Wang, Ping Luo, Jixuan Ma, Hai Zhang, Zhe Peng, Xiuqing Cui, Shuguang Xie, Xixiang Huo, ming zhang, Wei Bao, Tingming Shi, and Yuewei Liu Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.8b06942 • Publication Date (Web): 23 Apr 2019 Downloaded from http://pubs.acs.org on April 23, 2019
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Environmental Science & Technology
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Association of Exposure to Ambient Fine Particulate Matter Constituents
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With Semen Quality Among Men Attending a Fertility Center in China
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Xiji Huang1#, Bing Zhang2#, Li Wu3, Yun Zhou4, Yonggang Li1, Xiang Mao5, Ying Chen1,
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Jing Wang6, Ping Luo1, Jixuan Ma4, Hai Zhang1, Zhe Peng1, Xiuqing Cui1, Shuguang Xie6,
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Xixiang Huo6, Ming Zhang7, Wei Bao8, Tingming Shi9*, Yuewei Liu10, 1*
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1Hubei
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Disease Control and Prevention, Wuhan, Hubei 430079, China.
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2School
Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for
of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong
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518107, China.
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3Reproductive
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University of Science and Technology, Wuhan, Hubei 430030, China.
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4Key
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Environmental Protection, and State Key Laboratory of Environmental Health (Incubating),
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Department of Occupational and Environmental Health, School of Public Health, Tongji
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Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030,
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China.
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5Institute
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Control and Prevention, Wuhan, Hubei 430015, China.
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6Institute
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Disease Control and Prevention, Wuhan, Hubei 430079, China.
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7Tianjin
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8Department
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52242, USA.
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9Division
Medical Center, Tongji Hospital, Tongji Medical College, Huazhong
Laboratory of Environment and Health, Ministry of Education & Ministry of
of Environmental Health and Food Safety, Wuhan Municipal Center for Disease
of Health Surveillance, Analysis and Protection, Hubei Provincial Center for
Centers for Disease Control and Prevention, Tianjin 300011, China. of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa
of Personnel, Science and Education, Hubei Provincial Center for Disease Control 1
ACS Paragon Plus Environment
Environmental Science & Technology
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and Prevention, Wuhan, Hubei 430079, China.
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10Depeartment
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Guangzhou, Guangdong 510080, China.
of Epidemiology, School of Public Health, Sun Yat-sen University,
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# These
authors contributed equally to this work.
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*Corresponding
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Yuewei Liu, PhD, Department of Epidemiology, School of Public Health, Sun Yat-sen
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University, 74 Zhongshan Second Road, Guangzhou, Guangdong 510080, China. Telephone:
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+86-20-83653005. Email:
[email protected] 36
Tingming Shi, MD, Division of Personnel, Science and Education, Hubei Provincial Center
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for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan, Hubei 430079,
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China. Telephone: +86-27-87652050. Email:
[email protected] to:
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ACS Paragon Plus Environment
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Environmental Science & Technology
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ABSTRACT
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Ambient fine particulate matter (PM2.5) exposure has been linked to decreased semen quality,
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but the associations between PM2.5 constituent exposures and semen quality remain unknown.
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We enrolled 1081 men whose partners underwent assisted reproductive technology
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procedures in Wuhan, China in 2014-2015, and examined their semen quality. Daily average
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concentrations of PM2.5 constituents including 10 metals/metalloid elements and 4 water-
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soluble ions were continuously determined for 1 week per month at 2 fixed monitoring
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stations. Linear mixed models were used to examine the associations of exposures to PM2.5
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and its constituents with semen quality. Each interquartile range (36.5 μg/m3) increase in
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PM2.5 exposure was significantly associated with 8.5% (95% CI: 2.3%, 14.4%) and 8.1%
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(95% CI: 0.7%, 15.0%) decrease in sperm concentration and total sperm number,
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respectively. Antimony, cadmium, lead, manganese and nickel exposures were significantly
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associated with decreased sperm concentration, while manganese exposure was also
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significantly associated with decreased total motility. Non-smokers were more susceptible to
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PM2.5 constituent exposures, especially for antimony and cadmium (all P for effect
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modification
