Bioavailability and Biological Activity of Tea Polyphenols - American

and Chung S. Yang. Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State ..... Cancer Causes Control 1999, 10, 107-13. 12. Hollman, ...
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Chapter 2

Bioavailability and Biological Activity of Tea Polyphenols

Downloaded by UNIV OF PITTSBURGH on March 7, 2016 | http://pubs.acs.org Publication Date: June 19, 2003 | doi: 10.1021/bk-2003-0851.ch002

Hong Lu, Xiaofeng Meng, Mao-Jung Lee, Chuan Li, Pius Maliakal, and Chung S. Yang Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020

Tea polyphenols have biological activities including modulation of key signal transduction pathways. The possible significance of these activities in inhibition of carcinogenesis in vivo depends on the bioavailabilities of the polyphenols. After oral administration of tea to rats, about 14% of (-)epigallocatechin (EGC), 31% of (-)-epicatechin (EC), and