Downloaded by 80.82.77.83 on December 31, 2017 | http://pubs.acs.org Publication Date: December 11, 1993 | doi: 10.1021/bk-1993-0516.ix001
Author Index Appling, Dean R.,210 Arnold, Frances H., 102,109 Asgeirsson, B., 68 Baker, John O., 83 Baneyx, François, 140 Barlowe, Chartes Κ., 210 Barnett, C , 219 Berg, H., 219 Berka, R., 219 Bjamason, J. B., 68 Brown, R, 219 Bulow, Leif, 174 Chen, Keqin, 109 Chen, Wayne, 109 Chrunyk, Boris Α., 114 Cleland, Jeffrey L., 151 Dam, Mariana Van, 109 Donaldson, Gail K., 140 Economou, Chara, 109 Fowler, Tim, 233 Fox, J. W., 68 Gajiwala, Ketan, 18 Gatenby, Anthony Α., 140 Georgiou, George, 126 Gilkes, Neil R., 185 Greenwood, Jeffrey M., 185 Gritzali, M., 219 Gupta, Munishwar N., 307 Himmel, Michael E., 83 Horowitz, P. M., 167 Jaenicke, Rainer, 53 Johnson, Timothy J. Α., 283
Kellis, James T., Jr., 102 Kilburn, Douglas G., 185 Lorimer, George H., 140 Losiewicz, Michael, 265 Manning, Mark C , 33 Martinez, Pascal, 109 Miller, Robert C , Jr., 185 Ong, Edgar, 185 Pace, C.Nick, 18 Raju, R. R., 296 Sadana, Α., 296 Shiriey, Bret Α., 18 Shoemaker, S., 219 Strang, C. J., 195 Sturtevant, Julian M., 2 Sumner, L., 219 Swanson, R., 195 Thigpen, Anice E., 210 Umafla, Pablo, 102 Valax, Pascal, 126 van der Vies, Saskia M., 140 Viitanen, Paul V., 140 Wales, M. E., 195 Wang, Daniel I. C , 151 Warren, R. Anthony J., 185 Wetzel, Ronald, 114 Wild, J. R., 195 Wilson, David B., 243 Wong, Lee-Jun C , 265 Wong, Shan S., 265 Wu, J. H. David, 251 Yoon, KyungPyo, 109
Affiliation Index California Institute of Technology, 102,109 Chemical Center, Lund, Sweden, 174 Colorado State University, 283 Cornell University, 243 Ε. I. du Pont de Nemours and Company, 140 Genencor International, Inc., 219,233 Genentech, Inc., 151 Indian Institute of Technology, 307 Massachusetts Institute of Technology, 151
Memphis State University, 219 National Renewable Energy Laboratory, 83 SmithKline Beecham Pharmaceuticals, 114 Texas A&M University, 18,195 Universitât Regensburg, 53 University of British Columbia, 185 University of Colorado, 33 University of Florida, 219 University of Iceland, 68
327 Himmel and Georgiou; Biocatalyst Design for Stability and Specificity ACS Symposium Series; American Chemical Society: Washington, DC, 1993.
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BIOCATALYSIS DESIGN FOR STABILITY AND SPECIFICITY
University of Massachusetts, 265 University of Mississippi, 296 University of Rochester, 251 University of Texas Health Science 167,265
University of Texas, 126,210 University of Virginia Medical School, 68 Yale University, 2
Subject Index Aspartate transcarbamoylase modification allosteric binding site, residues, 200/.201 allosteric signal transfer from regulatory Acid-producing reactions, aldehyde-amine to catalytic subunits by zinc domains, chemistry, 284-286? 204-205 Acidophiles, definition, 54 amino acid sequences pyrl genes, 198,199f Active aldehydes, blocking, 293-294 Active site residues in cellulase, identification architecture and enzymatic characteristics, 196/,197/ through chemical modification, 247-248 holoenzyme, structural description, 202-204 Activity of enzymes, enhancement in hybrid oligomeric enzymes, formation from organic solvents, 111-113 regulatory and catalytic subunits, 205,206/ Acylating agents, characteristics, 267-269/ kinetic and allosteric comparison, 197,198/ Aggregation site-directed mutation vs. allosteric cosolvent effects, 151-164 response, 201/ growth parameter effects, 126-127 structural effect of secondary and pathway, 145 suprasecondary structures in transmitting protein stability and structure effects, 38 allosteric signals, 206,207/ suppression, 145-146 Atlantic cod, psychrophilic proteinases, 68-82 Aldehyde(s), laboratory safety, 294 Aldehyde-amine chemistry Β acid-producing reactions, 284-286* cross-linking, 287-292/.317 Bacterial proteins, interaction with GroE Alkaline phosphatase-trypsin conjugate, chaperonins, 144-145 preparation via cross-linking, 317 Barophiles, definition, 54 Alkalophiles, définition, 54 bgll gene in Trichoderma reesei, 235-240/ Alkylating agents, characteristics, 268,27Qf Amino acid replacements, protein stability Biconjugate preparation, cross-linking techniques, 315,317-321 and structure effect, 37-38,4Qf Biophysics, understanding of forces Amylases, structure-function relationship, 59,60/ causing folding, 2 Biothermodynamic data, methods, 3 Anaerobic bacteria, cloning and expression Bovine somatotropin, metal chelation, 104 of cellulase genes, 244 Anchor-enzyme model for cellulose degradation, use of Clostridium thermocellum cellulosome, 255,257,259f C Artificial bifunctional enzymes C5X, ethanol production, 236-238/ advantages, 182-183 Carbamoyl aspartate, formation, 195 β-gakctosidase-galactokinase, 178,179/ Catalytic ability, alteration as evolutionary β-galactosidase-galactose dehydrogenase, mechanism of enzymatic adaptation to 181-182 low temperature, 69 in vivo vs. in vitro studies, 180-181 CelL, key building block of Clostridium linker region, 178,180 thermocellum cellulosome, 257-258,260 pathway, 182
Downloaded by 80.82.77.83 on December 31, 2017 | http://pubs.acs.org Publication Date: December 11, 1993 | doi: 10.1021/bk-1993-0516.ix001
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Himmel and Georgiou; Biocatalyst Design for Stability and Specificity ACS Symposium Series; American Chemical Society: Washington, DC, 1993.
