BIOSIS Previews® The entire field of life sciences Produced by
BIOSIS
BioSciences Information Service
AT ITS BEST ON STN INTERNATIONAL
• Mounted on STN as a single file • Aerospace biology to zoology • From 1969 to the present
Biochemistry Biochemistry ( I S S N 0006-2960) is published biweekly by the American Chemical Society at 1155 16th Street, N . W . , Washington, D.C. 20036. Second-class postage paid at Washington, D . C , and additional mailing offices. P O S T M A S T E R : Send address changes to Biochemistry, Membership and Subscription Services, P.O. Box 3337, Columbus, Ohio 43210. American Chemical Society 1155 16th Street, N . W . Washington, D.C. 20036 (202) 872-4600 [TDD (202) 872-8733]
with STIM's CAS ONLINE and BIOMASS!
STN®
INTERNATIONAL
2 5 4 0 Olentangy River Road Box 0 2 2 2 8 Columbus, Ohio 4 3 2 0 2 USA Postfach 2 4 6 5 , D-7500 Karlsruhe 1 Federal Republic of Germany Gakkai Center Building 2-4-16 Yayoi, Bunkyo-ku Tokyo 11 3, Japan
JOURNALS
Membership and Subscription Services American Chemical Society P.O. Box 3337, Columbus, Ohio 43210 (614) 421-3776 Journals Department American Chemical Society 2540 Olentangy River Road P.O. Box 3330, Columbus, Ohio 43210 (614) 421-3600, ext 3171 ( T E L E X 6842086) © Copyright 1986 by the American Chem ical Society. Copyright permission: An indi vidual may make a single reprographic copy of an article in this publication for personal use. Reprographic copying beyond that permitted by Section 107 or 108 of the U.S. Copyright Law is allowed, provided that the appropriate per-copy fee is paid through the Copyright Clearance Center, Inc., 27 Congress St., Salem, Massachusetts 01970. For reprint permission, please write to the Copyright Administrator, Books and Journals Division, at the ACS Washington address. Editorial
Search BIOSIS Previews
Books and Journals Division D. H. Michael Bowen, Director
Information
Instructions to authors and copyright status form are printed in the first issue of each vol ume. Please conform to these instructions when submitting manuscripts. Manuscripts for publication should be sub mitted to the Editor, Hans Neurath, Depart ment of Biochemistry, University of Washing ton, Seattle, Washington 98195. Correspond ence regarding accepted papers and proofs should be directed to the Journals Department at the address above. Page charges of $30.00 per page may be paid for papers published in this journal. Payment does not affect accept ance or scheduling of papers. Bulk reprints of individual articles are available. For informa tion write to Distribution Office at the ACS Washington address. The American Chemical Society and its Ed itors assume no responsibility for the statements and opinions advanced by contributors. Registered names and trademarks, etc., used in this publication, even without specific indi cation thereof, are not to be considered unpro tected by law. Subscription and Business Information 1986 subscription prices including postage. All Other Europe Countries Air Service Air Service Included Mexico Included
Canada and U.S. Printed Members Nonmembers Microfiche Members Nonmembers Supplementary material on microfiche
$ 65 $334
S 98 $367
$130 $399
$155 $424
J 65 $334
$ 65 $334
$ 89 $358
$ 89 $358
$ 30
$ 40
$ 40
$ 40
Charles R. Bertsch, Head; Marianne C. Brogan, Associate Head; Franco A. Menezes and Mary E. Scanlan, Assistant Managers; Deborah K. Miller, Supervisory Editor; Darrell McGeorge, Jean M. Redmond, and Beth A. Rogers, Assistant Editors; Barbara I. Taylor and Brenda S. Wooten, Staff Editors RESEARCH AND DEVELOPMENT
Lorrin R. Garson, Head Advertising Office: Centcom, Ltd., 500 Post Road East, Westport. CT 06880. Subscriptions are available only on a calendar year basis. (For membership information, con tact Office of Membership Development at the ACS Washington address.) New and renewal subscriptions should be sent with payment to Business Management Division, ACS, P.O. Box 57136, West End Station, Washington, D.C. 20037. Rates do not apply to nonmember subscribers in Japan, who must enter subscription orders with Maruzen Company Ltd., 3-10 Nihonbashi 2chome, Chuo-ku, Tokyo 103, Japan. Tel: (03) 272-7211. Printed edition single issue prices: current year $14.00; prior year $16.00. Back volume price: $403.00. Foreign postage additional. Mail orders should be sent to Microforms & Back Issues Office at the ACS Washington address. Phone orders can be placed for print ed, microfiche, and microfilm editions by call ing the ACS Sales Office TOLL FREE at (800) 424-6747 from anywhere in the conti nental United States; Washington, D.C, area call (202) 872-8065. Phone orders can be charged to Visa, MasterCard, or American Express accounts. Changes of address must include both old and new addresses with ZIP code and a recent mailing label. Send all address changes to Membership and Subscription Services. Please allow 6 weeks for change to become effective. Claims for missing numbers will not be allowed if loss was due to failure of notice of change of address to be received in the time specified; if claim is dated (a) North America, more than 90 days beyond issue date; (b) all other foreign, more than one year beyond issue date; or if the reason given is "missing from files". Hard copy claims are handled by Membership and Sub scription Services. Supplementary material is noted in the table of contents with a • . It is available as photo copy ($6.00 for up to 3 pages and $1.50 per page for additional pages, plus $2.00 for foreign postage) or as 24X microfiche ($6.00, plus $ 1.00 for foreign postage). See supplementary material notice at end of journal article for number of pages. Orders must state whether for photocopy or microfiche and give complete title of article, names of authors, journal, issue date, and page numbers. Prepayment is re quired and prices are subject to change. Order from Microforms & Back Issues Office at the ACS Washington address. Supplementary material except structure factors also appears in the microfilm edition and may be ordered by subscription (in microfiche only). Cover: Based on apohemoglobin β subunit—courtesy of Jane S. Richardson.
Biochemistry EDITOR
HANS NEURATH Department of Biochemistry University of Washington Seattle, Washington 98195 (206) 543-1690
ASSOCIATE EDITORS E A R L W.
DAVIE
University of Washington EDMOND H. FISCHER
University of Washington M I L T O N P. G O R D O N
University of Washington W I L L I A M W.
PARSON
University of Washington
EDITORIAL ADVISORY BOARD ROBERT H. ABELES
CLAUDE HÉLÈNE
Brandeis University
DEMETRIOS PAPAHADJOPOULOS
University of California, San Francisco
DAVID S. AULD
Museum National d'Histoire Naturelle, Paris
Harvard Medical School
JOHN W. B. HERSHEY
Massachusetts Institute of Technology
ROBERT L. BALDWIN
University of California, Davis
DAVID C. PHILLIPS
Stanford University
PETER C. HINKLE
University of Oxford
STEVEN J. BENKOVIC
Cornell University, Ithaca
JAMES H. PRESTEGARD
The Pennsylvania State University
TONY E. HUGLI
Yale University
GUNTER BLOBEL
Scripps Clinic & Research Foundation
PETER REICHARD
The Rockefeller University
HANS JÖRNVALL
Karolinska Institute, Stockholm
AKSEL A. BOTHNER-BY
Karolinska Institute, Stockholm
JAMES F. RIORDAN
Carnegie-Mellon University
H. RONALD KABACK
Harvard Medical School
BILL R. BRINKLEY
Roche Institute of Molecular Biology
RANDY W. SCHEKMAN
Baylor College of Medicine
PAUL KAESBERG
University of California, Berkeley
ERNESTO CARAFOLI
University of Wisconsin
HAROLD A. SCHERAGA
ΕΤΗ, Zurich
NEVILLE R. KALLENBACH
Cornell University, Ithaca GÜNTHER SCHÜTZ
MARY LOU PARDUE
MINOR J. COON
University of Pennsylvania
The University of Michigan
GEORGES KOEHLER
RAYMOND A. DWEK
Basel Institute of Immunology, Basel
German Cancer Research Center, Heidelberg
University of Oxford
JOSEPH KRAUT
EDWARD M. SCOLNICK
WERNER W.
University of California at San Diego
Merck Sharp & Dohme
German Cancer Research Center, Heidelberg
ROBERT J. LEFKOWITZ
G. GRAHAM SHIPLEY
Duke University
Boston University
CARL FRIEDEN
HENRY METZGER
ANTERO G. S O
IRVING H. GOLDBERG
NIADDK, National Institutes of Health
CHARLES C. SWEELEY
Harvard Medical School
PAUL L. MODRICH
Michigan State University
RICHARD W. HANSON
Duke University
EDWIN W. TAYLOR
Case Western Reserve University
ELIZABETH NEUFELD
University of Chicago
WILLIAM F. HARRINGTON
University of California, Los Angeles
Johns Hopkins University
BERT L. VALLEE
JAMES OFENGAND
Harvard Medical School
ROBERT HASELKORN
Roche Institute of Molecular Biology
KENSAL Ε. VAN HOLDE
FRANKE
Washington University
University of Miami
University of Chicago
Oregon State University
OSAMU HAYAISHI
SALIH J. WAKIL
Osaka Medical College
Baylor College of Medicine