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Biochemistry Biochemistry ( I S S N 0006-2960) is published biweekly by the American Chemical Society at 1155 16th Street, N . W . , Washington, D.C. 20036. Second-class postage paid at Washington, D.C., and additional mailing offices. P O S T M A S T E R : Send address changes to Membership and Subscription Services, P.O. Box 3337, Columbus, Ohio 43210. American Chemical Society 1155 16th Street, N . W . Washington, D.C. 20036 (202) 872-4600 [TDD (202) 872-8733]

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EDITOR

HANS NEURATH Department of Biochemistry University of Washington Seattle, Washington 98195 (206) 543-1690 ASSOCIATE EDITORS E A R L W.

DAVIE

University of Washington EDMOND H. FISCHER

University of Washington M I L T O N P. G O R D O N

University of Washington W I L L I A M W.

PARSON

University of Washington

EDITORIAL ADVISORY BOARD ROBERT H. ABELES

JAMES OFENGAND

Brandeis University

WILLIAM F. HARINGTON

Roche Institute of Molecular Biology

DAVID S. AULD

Johns Hopkins University

DAVID C. PHILLIPS

Harvard Medical School ROBERT L. BALDWIN

OSAMU HAYAISHI

Osaka Medical College

University of Oxford

CLAUDE HÉLÈNE

JAMES H. PRESTEGARD

CLINTON E. BALLOU

Museum National d'Histoire Naturelle, Paris

PETER REICHARD

University of California, Berkeley

JOHN W. B. HERSHEY

Karolinska Institute, Stockholm

STEVEN J. BENKOVIC

University of California, Davis

JAMES F. RIORDAN

The Pennsylvania State University

PETER C. HINKLE

Harvard Medical School

JOHN L. BETHUNE

Cornell University, Ithaca

ANGELO M. SCANU

Harvard Medical School

HANS JÖRNVALL

University of Chicago

VICTOR A. BLOOMFIELD

Karolinska Institute, Stockholm

HAROLD A. SCHERAGA

University of Minnesota

H. RONALD KABACK

Cornell University, Ithaca

JAMES BONNER

Roche Institute of Molecular Biology

GÜNTHER SCHÜTZ

California Institute of Technology

NEVILLE R. KALLENBACH

AKSEL A. BOTHNER-BY

University of Pennsylvania

German Cancer Research Center, Heidelberg

Carnegie-Mellon University

MARTIN D. KAMEN

G. GRAHAM SHIPLEY

BILL R. BRINKLEY

Scripps Institute, La Jolla

Boston University

Baylor College of Medicine

JOHN A. KATZENELLENBOGEN

S. JONATHAN SINGER

Stanford University

Yale University

MINOR J. COON

University of Illinois, Urbana

University of California at San Diego

The University of Michigan

GEORGES KOEHLER

ANTERO G. SO

NICHOLAS R. COZZARELLI

Basel Institute of Immunology, Basel

University of Miami

University of California, Berkeley

JOSEPH KRAUT

CHARLES C. SWEELEY

RAYMOND A. DWEK

University of California at San Diego

Michigan State University

University of Oxford

HENRY METZGER

EDWIN W. TAYLOR

WERNER W. FRANKE

NIADDK, National Institutes of Health

University of Chicago

DAVID E. METZGER

Brandeis University

German Cancer Research Center, Heidelberg CARL FRIEDEN

SERGE N. TIMASHEFF

Iowa State University

Washington University

BERT L. VALLEE

RICHARD W. HANSON

Harvard Medical School

Case Western Reserve University

KENSAL E. VAN HOLDE

Oregon State University