ARTICLE pubs.acs.org/Macromolecules
Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible AdditionFragmentation Chain Transfer Polymerization and Click Chemistry Kui Luo,† Jiyuan Yang,† Pavla Kopeckova,† and Jindrich Kopecek*,†,‡ †
Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD and ‡Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112-9452, United States
bS Supporting Information ABSTRACT: A new bifunctional chain transfer agent (CTA) containing alkyne end groups was designed, synthesized, and used for direct synthesis of clickable telechelic polymers. Good control of reversible additionfragmentation chain transfer (RAFT) polymerization of N-(2-hydroxypropyl)methacrylamide (HPMA) was achieved by using the new CTA, as indicated by a linear increase of number-average molecular weight (Mn) with conversion and low polydispersity (PDI) (
