Downloaded by 80.82.77.83 on January 21, 2018 | http://pubs.acs.org Publication Date: August 12, 2002 | doi: 10.1021/bk-2002-0830.pr001
Preface
What many think o f as modern biochemical production technology began in the early 1940s, as an effort to meet the increasing demand for penicillin during W o r l d War II. During that time, penicillin production moved from surface culture in milk bottles to submerged culture in tanks as large as 100,000 L . In the 60 years since then, significant advances in biochemical production technologies have occurred, as dramatic advances have been made i n our understanding o f cellular systems, and how these systems can be manipulated to produce desirable products. Today, production o f biochemicals includes not only traditional subjects such as fermentation engineering and applied microbiology, but subjects as diverse as recombinant DNA technology, metabolic engineering, genomics, and combinatorial chemistry (just to name a few). This field continues to evolve as new technologies become available to operate, monitor and control bioprocesses, and as new biological discoveries are made at an ever increasing pace. The majority o f the papers contained in this text were presented at the PacifiChem 2000 conference, held in Honolulu, H a w a i i in Decem -ber 2000. Our goal in organizing this symposium and in compiling this book was to bring together scientists from around the Pacific R i m who are using various modern biological tools to study various aspects o f biochemical production. The book is divided into three sections: (1) microbial and enzymatic systems, (2) animal cell systems, and (3) combinatorial engineering and analytical methods. Expression systems discussed in various chapters are used for the production o f organic acids, specialty sugars, enzymes, and antibodies. Our hope is that this book w i l l benefit the reader by providing a glimpse o f how modern biological tools are being applied to the production o f a mixture o f biochemical products. The editors thank the American Chemical Society B o o k s Department o f the Publications Division for assistance in the process,
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Marten et al.; Biological Systems Engineering ACS Symposium Series; American Chemical Society: Washington, DC, 2002.
especially K e l l y Dennis and Stacy V a n D e r W a l l in acquisitions Margaret B r o w n in editing/production for all their help.
Mark R. Marten University o f Maryland - Baltimore County Department of Chemical and Biochemical Engineering 1000 Hilltop Circle Baltimore, MD 21250
Downloaded by 80.82.77.83 on January 21, 2018 | http://pubs.acs.org Publication Date: August 12, 2002 | doi: 10.1021/bk-2002-0830.pr001
Tai Hyun Park Seoul National University School o f Chemical Engineering San 5 6 - 1 , Shilim-dong, Kwanak-gu Seoul 151-744, K o r e a
Teruyuki Nagamune The University o f Tokyo Department o f Chemistry and Biotechnology School o f Engineering 7-3-1 Hongo, Bunkyo-ku Tokyo, Japan 113-8656
Marten et al.; Biological Systems Engineering ACS Symposium Series; American Chemical Society: Washington, DC, 2002.
