Biomimetic macromolecular chemistry: design and synthesis of an

Macromolecules 1992,25, 5398-5407

5398

Biomimetic Macromolecular Chemistry: Design and Synthesis of an Artificial Ion Channel Based on a Polymer Containing Cofacially Stacked Crown Ether Rings. Incorporation in Dihexadecyl Phosphate Vesicles and Study of Cobalt Ion Transport Maarten F. M.Roksl* and Roeland J. M.Nolte'Jb Departments of Organic Chemistry, University of Utrecht, 3584 CH Utrecht, The Netherlands, and University of Nijmegen, 6525 ED Nijmegen, The Netherlands Received December 18, 1991;Revised Manuscript Received June 23, 1992

ABSTRACT: We describe a syntheticmodel of a natural channel-formingionophore. It is based on apolymer with a rigid backbone, viz. a polymer of an isocyanide, [R-N=C