Breaking the Aromatic Stabilization of the Pyridine Ring Using a Tungsten-Based "Molecular Vise" : Diels-Alder reactions with Dihapto-coordinated Pyridines... and Beyond...
Z
R
R N Me3P Tp
W
R
Z
Me3P Tp
W
R
N
Z
R
AgOTf
NO
NO
Coordinated pyridines can be elaborated into many different types of piperidine systems as well offering new leads for potential pharmaceuticals
Coordination of a pyridine ring activates this common class of molecules to undergo new types of reactions including Diels-Alder cycloaddition reactions
N
R
Tp
Y
PMe3 NO W
X N
N O
Z
O
