Instrumentation
(announcing... Spectrum-Marine announces Ιο-Quant, a hyper sensitive permanently stable indicator solution for iodometric and iodimetric determinations. Ap plications include all deter mi nations in vol vin g the lô" complex.
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Chemists and researchers no longer need to spend valuable time preparing fresh iodine indicator. Ιο-Quant is always ready to use in its convenient dropper bottle. We have shelf and bench life data for seven years and there is no known instance of Ιο-Quant concentrate deter iorating or developing sensitivity losses due to aging. Ιο-Quant permits more than twenty-five times the number of titrations done by an equal volume of conventional stabilized starch indicators. À single drop produces an intense blue color in the presence of even trace amounts of molecular iodine. T h i r t y - s i x grams are sufficient for 900 determinations and its sharper end point results in greater precision. Ιο-Quant is more than a convenient time saver. Its stability makes it ideal for use in analytical kits for field trips and cruises at a cost of less than Vi of one cent per titration. Purchases may be made through selected dis tributors or direct from Spectrum-Marine in the following sizes: 36 gram dropper bottle $ 3.75 Case of 6 $ 18.75 72 gram dropper bottle $ 6.00 Case of 6 $ 30.00 500 gram regular bottle $25.50 Case of 6 $127.50 All orders are shipped promptly and post paid in the U.S.A.
SPECTRUM-MARINE RESEARCH LABORATORIES, INC. P.O. BOX 7219
• LUDLUMBRANCH Phone: 305-221-7702 -
• MIAMI, F L O R I D A 33155 305-688-2772
t h i s procedure, all of t h e serum proteins, including t h e immunoglobulins, can be q u a n t i t a t e d . Carbamylation of serum proteins with potassium c y a n a t e (18) is another m e t h o d which produces similar chemical modification. T h e efficiency with which these analyses are performed m a y be addi tionally improved b y t h e mechanization of some of t h e steps or b y t h e develop m e n t of an appropriate a p p a r a t u s t o handle a larger number of samples. T h u s , it is our conviction t h a t t h e gap between t h e development and applica tion of two-directional Immunoelectro phoresis and its potential use in t h e routine clinical chemistry laboratory as a diagnostic tool is closing. I n addition, t h e technique is now beginning t o find use in t h e basic research laboratory since it provides t h e investigator with a powerful tool for t h e qualitative a n d q u a n t i t a t i v e analysis of proteins. Acknowledgment
T h e a u t h o r s express their appreciation t o K a r l Linke and Chester M . Sinnett of t h e I n s t r u m e n t Division of t h e William Pepper L a b o r a t o r y for their invaluable assistance in t h e design and manufacture of t h e a p p a r a t u s used in this investiga tive work. References
CIRCLE 1 9 0 O N READER SERVICE CARD
Speed up your drug determination!
ROTARY EVAPO-MIX • Evaporate up to 4 ml/min of chloroform* • Multiple use of test tubes • Internally mounted temper ature-controlled water ba(N • Exclusive Orbital Mixing Action » Simultaneous concentration or evaporation of 10 samples • When used With a Buchler Aspirator Pump or other satisfactory source of vacuum. :
BUCHLER INSTRUMENTS DIVISION BUCHLER INSTRUMENTS
NUCLEAR-CHICAGO CORP. Λ SUBSIDIARY OF CO. [ S E A R L E I > CO.-
13H7 SIXTEENTH STR«T,fpttT IÉ6, «EW JERSEY, 0Ϊ024 CIRCLE 19 ON READER SERVICE CARD
60 A
ANALYTICAL CHEMISTRY, VOL. 4 4 , NO. 9 , AUGUST 1972
(1) P. Grabar and C. A. Williams, Jr., Biochem. Biophys. Acta, 10, 193 (1953). (2) N . Ressler, Clin. Chim. Acta, 5, 795 (1960). (3) C. B. Laurell, Anal. Biochem., 10, 358 (1965). (4) H. G. M. Clarke and T. Freeman, Clin. Sci., 35, 403 (1968). (5) C. B. Laurell, Anal. Biochem., 15, 45 (1966). (6) B. Weeke, Scand. J. Clin. Lab. Invest., 25, 269 (1970). (7) V. A. Raisys and D. A. Arvan, Clin. Chem., 17, 745 (1971). (8) D . A. Arvan and L. M. Shaw, Separ. Sci., in press, 1972. (9) V. W. Stephan and TJ. Frahm, Z. Klin. Chem. Klin. Biochem., 9, 224 (1971). (10) H . G. M. Clarke, T. Freeman, and W. Ε. Μ. Pryse-Phillips, Clin. Chim. Acta, 30, 65 (1970). (11) A. H. Amin, H. G. Clarke, T. Free man, I. M. Lyon, P. M. Smith, and R. Williams, Clin. Sci., 38, 613 (1970). (12) H. G. M. Clarke, T. Freeman, R. Hickman, and W. Ε. Μ. Pryse-Phillips, Thorax, 25, 423 (1970). (13) H. G. M. Clarke, T. Freeman, and W. Ε. Μ. Pryse-Phillips, Clin. Sci., 40, 337 (1971). (14) I. M. Murrary-Lyon, R. Williams, T. Freeman, and H. G. M. Clarke, Nature, 231, 45 (1971). (15) M. K. Fagerhol and C. B. Laurell, Clin. Chim. Acta, 16, 199 (1967). (16) C. A. Alper and R. P. Propp, J. Clin. Invest., 47, 2181 (1968). (17) Ν . Η. Axelsen, Inf. Immun., 4, 525 (1971). (18) B. Weeke, Scand. J. Clin. Lab. Invest., 21, 351 (1968).
