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Carbonic Anhydrase-II Inhibition. What Are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate? Bruce E. Maryanoff*, David ...
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3660 Journal of Medicinal Chemistry, 2008, Vol. 51, No. 12

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Additions and Corrections

2008, Volume 51 Bruce E. Maryanoff,* David F. McComsey, Jung Lee, Virginia L. Smith-Swintosky, Yuanping Wang, Lisa K. Minor, and Matthew J. Todd: Carbonic Anhydrase-II Inhibition. What Are the True Enzyme–Inhibitory Properties of the Sulfamide Cognate of Topiramate?. Page 2521. References 13 and 14 are incorrect with respect to the partitioning of their content. The correct version follows: (13) (a) This C8 methyl is the pro-S methyl on the 4,5-cyclic ketal. (b) In the crystallographic study of 2 · CA-II (with 1.9 Å resolution), no electron density was observed for the C8 methyl group in question.12 (14) Maryanoff, B. E.; Costanzo, M. J.; Nortey, S. O.; Greco, M. N.; Shank, R. P.; Schupsky, J. J.; Ortegon, M. E.; Vaught, J. L. Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. J. Med. Chem. 1998, 41, 1315-1343. JM8004916 10.1021/jm8004916 Published on Web 05/22/2008

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