Comparative Study of Global Protein Turnover in Tissues and Cell Lines
WEBINARS Stronger bonds.
OCTOBER 24, 2013 11:00 a.m. EDT, 10:00 a.m. CDT, 8:00 a.m. PDT, 15:00 GMT
SPEAKER
MODERATOR
Christian Ravnsborg, Product Manager, Termo Fisher Scientifc
Jef Huber, Associate Editor, C&EN
SPONSOR
OVERVIEW Despite the success of mass spectrometry-based analysis of protein expression, the more fundamental question of protein turnover remains a challenge. Te proteome is extremely dynamic and exists in constant fux. Most studies present one particular state of proteome at a given time with given conditions and do not describe the level of proteinsynthesis and degradation. Recent attempts to study protein turnover, based on stable isotope labeling, use diferent approaches and diferent algorithms for data processing. Here we perform a comparative analysis of rates of protein turnover from these diferent approaches from a variety of tissues and cell lines using the Termo Scientifc™ ProteinCenter™ sofware.
WHO SHOULD ATTEND Transcriptome researchers Proteome researchers
KEY LEARNING OBJECTIVES:
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Understand the challenges of complex comparison studies of protein turnover derived from experimental data, available databases and literature
