Anal. Chem. 2011, 83, 99–108
Certification of Vitamins and Carotenoids in SRM 3280 Multivitamin/Multielement Tablets L. C. Sander,*,† K. E. Sharpless,† S. A. Wise,† B. C. Nelson,‡ K. W. Phinney,† B. J. Porter,† C. A. Rimmer,† J. B. Thomas,† L. J. Wood,† J. H. Yen,§ D. L. Duewer,† R. Atkinson,| P. Chen,| R. Goldschmidt,| W. R. Wolf,| I.-P. Ho,⊥ and J. M. Betz∇ Analytical Chemistry Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, MS 8311, Gaithersburg, Maryland 20899-8392, United States; Biochemical Science Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, MS 8311, Gaithersburg, Maryland 20899-8392, United States; Statistical Engineering Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, MS 8980, Gaithersburg, Maryland 20899-8980, United States; Food Composition and Methods Development Laboratory, U.S. Department of Agriculture (USDA), 10300 Baltimore Blvd, Beltsville, Maryland 20705, United States; Grocery Manufacturers Association (GMA), 1350 I Street, NW, Suite 300, Washington, District of Columbia 20005, United States; and Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Room 3B01, Bethesda, Maryland 20892, United States A new multivitamin/multielement dietary supplement Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST), with certified and reference concentration values for 13 vitamins, 24 elements, and 2 carotenoids. The constituents have been measured by multiple analytical methods with data contributed by NIST and by collaborating laboratories. This effort included the first use of isotope dilution mass spectrometry for value assignment of both fat-soluble vitamins (FSVs) and water-soluble vitamins (WSVs). Excellent agreement was obtained among the methods, with relative expanded uncertainties for the certified concentration values typically ranging from
