ARTICLE
Characterizing the Interactions of Organic Nanoparticles with Renal Epithelial Cells in Vivo Anil V. Nair,†,‡ Edmund J. Keliher,† Amanda B. Core,†,‡ Dennis Brown,†,‡ and Ralph Weissleder*,†,§ †
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States, ‡Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 United States, and §Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States
ABSTRACT Nanotechnology approaches are actively being pur-
sued for drug delivery, novel diagnostics, implantable devices, and consumer products. While considerable research has been performed on the effects of these materials on targeted tumor or phagocytic cells, relatively little is known about their effects on renal cells. This becomes critical for supersmall nanoparticles (
