Journal ofMedicina1 Chemistry, 1974,Vol. 17,No.7 747
Notes Table 111. Biological Activities0 Compd 14 15 16
17 18 19 20 21 22 23 24 25 26 27 28 29 30 Chlorpromazine Cogentin
Antihypertensive Dose6 Activity“
D MAd
+
50 75 75 30 60 20 25 60
>400 12.7 12.7 4 >400 40 40 12.7 127 12.7 >400 400 40 40 127 40 127 12.7 >400
+++ ++++ Z t
f
++
60 40
+t
30 30
=I= =k
75 5
=k
i
++
Prelim assessment Antimorphine Antitremorinel Ptosis Hyperemia EDNb EDwb
>400 40 12.7 4 400 12.7 40 0.4 40 1.27 >400 >400 12.7 12.7 127 40 >400 4.0 >400
400 400 12.7 12.7 400 40 40 12.7 127 12.7 >400 >400 12.7 12.7 >400 400 >400 >400 >400
74 200 13 17 Synn 9.5 35 2.6 120 4.5 330 155 22 66 320 350 >400 5.6 20.5
16 >400 21 21 Syng 34 Syno 31 118 15 60 120 6.4 7 240 47 370 10.5 1.39
Osee test for experimental details. *Dose expressed as mg/kg. CFalls in systolic pressure 2 hr after an intraperitoneal dose: >50 mm, 50-30 mm, 30-15 mm,
