Chemical Reviews special thematic issue
Combinatorial Chemistry This special thematic issue of Chemical Reviews offers a sampling of current efforts in this exciting field. Reflecting the diversity of efforts that is contained within combinatorial chemistry, the reviewers' viewpoints run from the strictly synthetic to almost purely biochemical.
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Osborne and Ellington focus on the selection of binding motifs from random libraries, including efforts to increase diversity and manipulate the properties of the selected entities through the use of nucleotide analogs.
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Breaker explores the catalytic abilities of nucleic acids and the use of increasingly sophisticated selections to derive catalysts for an ever wider range of chemical transformations. Petrenko and Smith provide a comprehensive survey of the peptide motifs that have been isolated or defined by phage display of peptides and proteins and offer some interesting comments on strategies for the exploration of seouence space. Lam, Lebl, and Krehnak review the one-bead-one-compound approach with coverage of synthetic methods, screening technologies, approaches to decoding theses pools, and an array of specific examples of compounds isolated in this manner.
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Nefzi, Ostresh, and Houghten descrrbe the remarkable range of classes of chemical compounds for which libraries have been synthesized by solid-phase methods. Pirrung focuses on spatially addressable synthetic approaches to solid-phase synthesis. Gravert and |anda survey recent progress in a hybrid approach to library synthesis—the use of soluble polymeric supports in efforts to combine the advantages of traditional liouid/phase synthesis with the benefits of solid-phase synthesis.
7 Essential Reviews 14 International Contributors Guest Editor Jack W. Szostak, Department of Molecular Biology, Massachusetts General Hospital Purchase vour own copy now at the special ACS member rate of onlv $30! (nonmembers $40)
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Analytical Chemistry News & Features, November 1, 1997 687 A
