ChiPros® - Essential Part of Pharmaceutical, Crop Protection Agent Synthesis Dr. Klaus Ditrich
BASF provides customers with easy access to its ChiPros technology, a wide and growing portfolio of chiral intermediates that includes amines, alcohols, aminoalcohols, acids and epoxides. Just as important, we provide easy access to our scientists to help our customers to be more successful with their syntheses using our innovative technologies. We also stand ready to develop new molecules to satisfy specific customers' needs.
ls;iB#y i ' Stuermer Dr. John Banger
High Purity Enantiomers Biocatalysis
High Enzyme Technologies New Services
The most important method for production of chiral compounds employs enzymes as natural catalysts.
BASF utilizes several new enzyme technologies to create chiral alcohols from epoxides, beta-hydroxyacids, aminoalcohols and oxazolidinones. The uniformly high enantioselectivity and the broad applicability of this technology are especially noteworthy.
Glen Templin
"Optimized over a billion years of evolution, these biocatalysts are highly effective and have high process purity when the reaction is well controlled," said Dr. Klaus Ditrich of BASF Fine Chemicals and Biocatalysis Research in Germany. In 1993, BASF scientists discovered that an enzyme of the lipase family catalyzes reactions between amines and carboxylic acid esters. This process paved the way for the expansion of synthesis techniques that build on biocatalysis. Dr. Frank Stein
"The big advantage of this process for our customers is the enormous range of potential substrates," said Dr. John Banger of BASF's Chemical Intermediates business in Florham Park, N.J. "With more than 50 optically active variants of this class of substances, BASF is currently the world's leading supplier of chiral amines, with more in the development pipeline. No competing method, such as crystallization or asymmetric hydrogenation, can produce such product diversity." "Biocatalytic processes offer huge advantages, including more effective use of starting materials, less waste product creation, and operation at milder conditions with less energy or lower pressure," said Dr. Rainer Stuermer of BASF's Fine Chemicals and Biocatalysis Research in Germany. "Nature has the best methods for achieving optical purity, and we seek to emulate them."
"BASF also offers enzyme engineering, scale up and production services to support pharmaceutical producers' use of chiral intermediates technologies," said Glen Templin, Business Development Manager for BASF's Life Science Intermediates business in North America, located in Florham Park, N.J. "These innovative technologies are very helpful in improving the success of pharmaceutical synthesis."
Greater Possibilities - Asymmetric Hydrogenation Asymmetric hydrogenation expands the possibilities for creating the precise chiral intermediates that a customer needs. Increasing demand for single-enantiomer compounds has helped the asymmetric hydrogenation of carbon-oxygen and carbon-carbon double bonds to develop into a valuable industrial production method. Using high throughput screening and access to large ligand libraries, BASF is able to create and test many different catalysts for the asymmetric hydrogenation of potential reaction partners, and thereby create more tailor-made chiral building blocks for customers.
BASF also employs a new process involving dehydrogenases to facilitate a biological reduction of ketones to chiral alcohols, and the company operates two traditional chemical processes for chiral intermediate production. "Our diversity of methods is a strong advantage for our customers because it enables us to support them in a customized manner," said Dr. Frank Stein of BASF's Intermediates business in North America. More than the parts for higher efficiency and improved purity. Intermediates from BASF for life sciences and lots more. * Global. Innovative. Valuable. Reliable.
More information More information about the BASF ChiPros line of chiral intermediates can be found at www.thinkchiral.com. Request more at AdlnfoNow.org
•-BASF The Chemical Company
