Chloramphenicol1 (Chloromycetin). VI. A Synthetic Approach

d-(-)-threo-l-p-N itrophenyl-2-dichloroaceta- mido-1,3-propanediol (I) has been shown to be the structure13 of chloramphenicol, an anti-. (N=C—CHC1,...
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July, 1949

2469

S Y N T H E T I C A P P R O A C H TO C H L O R A M P H E N I C O L [ C O S T R I B U T I O N FROM T H E R E S E A R C H

LABORATORIES OF

.

Chloramphenicol’ (Chloromycetin)

PARKE, DAVIS

& CO.1

VI. A Synthetic Approach

BY LORENM. LONGAND H. D. TROUTMAN D- (-)-threo-1 -p-Nitrophenyl-2-dichloroacetamido- L ,: