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Bioactive Constituents, Metabolites, and Functions
Citrus kawachiensis peel powder reduces intestinal barrier defects and inflammation in colitic mice Ayami Kawabata, Tran Van Hung, Yoko Nagata, Noahiro Fukuda, and takuya suzuki J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.8b03511 • Publication Date (Web): 02 Oct 2018 Downloaded from http://pubs.acs.org on October 3, 2018
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Journal of Agricultural and Food Chemistry
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Citrus kawachiensis peel powder reduces intestinal barrier defects and inflammation in
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colitic mice
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Ayami Kawabata1, Tran Van Hung1, 2, Yoko Nagata3, Naohiro Fukuda4, and Takuya Suzuki1
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Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima 739-8528, Japan.
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District, Ho Chi Minh 700000, Vietnam
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Kubotamachi, Matsuyama 791-1101, Japan
Department of Biofunctional Science and Technology, Graduate School of Biosphere
Ho Chi Minh University of Food Industry, 140 Le Trong Tan, Tay Thanh Ward, Tan Phu
Food Industrial Technolegy Center, Ehime Institute of Industrial Technology, 487-2, Kume-
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2, Kume-Kubotamachi, Matsuyama 791-1101, Japan
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Department of Planning and Development, Ehime Institute of Industrial Technology, 487-
Address for correspondence:
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Name:
Takuya Suzuki, Ph.D., Professor
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Mailing address:
1-4-4, Kagamiyama, Higashi-Hiroshima, 739-8528, Japan
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Telephone number:
81-82-424-7984
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Fax number:
81-82-424-7916
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Email address:
[email protected] 18
Abbreviations:
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Cxcl-2: chemokine C-X-C motif ligand-2; DF: dietary fiber; DSS: dextran sodium sulfate; IBD:
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inflammatory bowel disease; IL: interleukin; JAM: junctional adhesion molecule; LBP:
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lipopolysaccharide-binding protein; TJ: tight junction; TNF: tumor necrosis factor; ZO: zonula
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occludens.
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1 ACS Paragon Plus Environment
Journal of Agricultural and Food Chemistry
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Abstract
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The anti-inflammatory effect of Citrus kawachiensis peel powder was examined in a murine
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model of dextran sodium sulfate (DSS)-induced colitic mice. In addition to the whole powder,
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its ethanol extract rich in polyphenolic compounds and ethanol extraction residue rich in dietary
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fibers (DFs) were used. The whole powder ameliorated the DSS-induced body weight loss
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(body weight changes on day 9, Control 108±2, DSS 91±4, DSS+whole peel powder 106±1 %,
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p
