Anal. Chem. 1995, 67, 377R-524R
Clinical Chemistry David J. Anderson, Coordinator Department of Chemistry, Cleveland State University, Cleveland, Ohio 44 115
Frederick Van Lente, Coordinator Section of Biochemistry, The Cleveland Clinic Foundation, Cleveland, Ohio 44 195
Review Contents Clinical Topics
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Cardiovascular (Biochemical Assessment of Reperfusion) Frederick Van Lente, The Cleveland Clinic Foundation
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Renal Function (Microalbuminuria) Kory M. Ward, The Ohio State University
383R
Endocrine (Standardization of Glycohemoglobin Measurement) Randie R. Little and David E. Goldstein, University of Missouri School of Medicine
393R
Cancer (Prostate-Specific Antigen) William J. Castellani, The Cleveland Clinic Foundation
399R
Trace Metals (Lead and Cadmium Exposure Screening) Rose T. Daher, The Cleveland Clinic Foundation
405R
Free Radicals (Nitric Oxide) Peter Kostka, Cleveland State University
411R
Solid-Organ Transplantation John A. Lott, The Ohio State University
417R
Diseases of Metabolism (Porphyrias) Nuala A. McCavoEl, St. James’ Hospital
425R
Nutritional Assessment (Protein Nutriture) A. Michael Spiekerman, Scott & White Hospital
429R
Clinical Informatics Steven C. Kazmierczak and Paul G. Catrou, East Carolina University School of Medicine
437R
Statistics Carl C. Garber, Corning MetPath Clinical Laboratory
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Instrumental Topics Molecular Biology Techniques Kristen J. Skogerboe, Laboratory of Pathology
449R
Immunoassays David S. Hage, University of Nebraska
455R
Capillary Electrophoresis Yan Xu, Cleveland State University
463R
High-Performance Liquid Chromatography (Advances in Packing Materials) David J. Anderson, Cleveland State University
475R
Electroanalysis and Biosensors Joseph Wang, New Mexico State University
487R
Mass Spectrometry Michael Kinter, University of Virginia
493R
Chemiluminescence and Bioluminescence Larry J. Kricka, University of Pennsylvania
499R
Flame, Flameless, and Plasma Spectroscopy Nancy W Alcock, University of Texas Medical Branch
503R
Nuclear Magnetic Resonance Spectroscopy Ian C. P. Smith and Dorothea E. Blandford, National Research Council of Canada
509R
Clinical Instrumentation (Immunoassay Analyzers) Daniel W. Chan, Johns Hopkins University
519R
This review is divided into two major sections: clinical and instrumental. W ithii these sections there are various subsections, each of which is reviewed by individuals having expertise within 0003-2700/95/0367-0377$15.50/0 0 1995 American Chemical Society
the topic area. The period covered by the review is specified by the author($ of each subsection in terms of the ChemicalAbstracts date, ending on October 1,1994. The ultimate objective is to bring Analytical Chemistry, Vol. 67, No. 12,June 15, 1995 377R
the reader up to current status within each topic area. Limitations on the scope of topics covered are presented by each reviewer. The clinical section is divided into 11 subsections, with the division of topics being based on the type of disease or condition. The subsections covered are as follows: cardiovascular (biochemical assessment of reperfusion); renal function (microalbuminuria); endocrine (standardization of glycohemoglobin measurement) ; cancer (prostatespecific antigen); trace metals (lead and cadmium exposure screening); free radicals (nitric oxide); solid-organ transplantation; diseases of metabolism (porphyrias); nutritional assessment (protein nutriture) ; clinical informatics; and statistics. The focus of the clinical section is laboratory issues related to diagnosis, prognosis, and treatment. This part of the review not only serves the clinical chemist by providing a comprehensive summary of the various issues within the subsec-
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Analytical Chemistry, Vol. 67, No. 12, June 15, 1995
tion’s topic area, but it is also written to familiarize the analytical chemist with pertinent clinical issues. The instrumental section is divided into 10 subsections, covering advances in technical aspects as applied to the determination of clinically relevant compounds. The subsections covered are as follows: molecular biology techniques; immunoassays; capillary electrophoresis;high-performanceliquid chromatography (advances in packing materials); electroanalysis and biosensors; mass spectrometry; chemiluminescence and bioluminescence; flame, flameless, and plasma spectroscopy; nuclear magnetic resonance spectroscopy; and clinical instrumentation (immunoassay analyzers). This part of the review is written to keep the clinical chemist abreast of advances in analytical chemistry relevant to the clinical laboratory.
