Anal. Chem. 1981, 53, 214R-233R (5V) Blanchet, P. F., J . Chromatogr., 779, 123-9 (1979); Pesticide Abstr., 80-0884 (1980). (6V) Blanchet, P. F., J . Agric. Food Chem., 2 7 , 204-6 (1979); Pesticlde Abstr.. 79-0990 (1979). (7V) Bowmer, K. H., Adeney, J. A., Pestic. Sci., 9 , 342-53 (1978); Pesticide Abstr., 79-0747 (1979). (8V) Brodtmann, N. V., Koffskey, W. E., J . Chromatogr. Sci., 77, 97-110 (1979); Pesticide Abstr., 79-1487 (1979). (9V) Chmil', V. D., Zh. Anal. Khim., 34, 2067-70 (1979); Pesticide Absfr., 80-1200 (1980). (IOV) Chmil', V. D., Klisenko, M. A,, ibid., 32, 592-5 (1977); Pesticide Abstr., 78-2248 (1978). (11V) Chmil', V. D., Pilenkova, I. I., Far'yanova, A. D., Zorova, A. I., Gig. Sanit., 43, 56-8 (1978); Pesticide Abstr., 79-0981 (1979). (12V) Chrnll', V. D., Pilenkova, I. I., Fat'ianova, A. D., Zorova, A. I., ibld., 44, 57-8 (1979); Pesticide Abstr., 79-1968 (1979). (13V) Copin, A., Delmarcelle, J., Deleu, R., Renaud, A,, Anal. Chim. Acta, 776, 145-52 (1980). (14V) Dawson, V. K., Harman, P. D , Schultz, D. P., Allen, J. L., J . Fish. Res. Board Can.. 35, 1262-5 (1978); Pesticide Abstr., 79-0239 (1979). (15V) Deleu, R., Copin, A., J . Chromatogr.. 777, 263-8 (1979); Pesticide Ab&., 79-1738 (1979). (16V) Devenish, I. W., Hading-Bowen, L., Environ. Sci. Res., 76, 231-53 (1978, Pub. 1980); Chem. Abstr., 93, 31516x (1980). (17V) DiPrima, S.J., Cannlzzaro, R. D., Roger, J. C., Ferrell, C. D., J . Agrlc. Food Chem., 2 6 , 968-71 (1978); Pesticide Abstr., 78-2486 (1978). (18V) Dressler, M., J. Chromatogr., 765, 167-206 (1979); Pesticide Absfr.. 79-2835 (1979). (19V) Ershova, K. P., Komarova, N. S.,Shitukhina, A. F., Gig. Sanit., 43, 69-70 (1978); Pesticide Abstr., 79-0740 (1979). (2OV) Faas, L. F., Moore, J. C., J . Agric. Food Chem., 2 7 , 554-7 (1979); Pesticide Abstr., 79-1969 (1979). (21V) Fritschi, U., Fritschi, G., Kussmaul, H., Z Wasser Abwasser-Forsch., 1 7 , 165-7 (1978); Pesticide Abstr., 79-1000 (1979). (22V) Getz, M. E., Hanes, G. W., HIII, K. R., NBS Spec. Publ. ( U . S . ) , 579, 345-53 (1979); Pesticide Abstr., 79-3131 (1979). (23V) Handa, S . K., J . Assoc. Off. Anal. Chem., 63, 200-1 (1980). (24V) Kadaba, P. K., Bhagat, P. K., Osredkar, R., Murthy, V. R. K., Report, RR- 776, W79-01987, OWRT-A-065-ky No. PB-289370, Avail. NTIS, 69 pp (1979). (25V) Krasnykh, A. A., Gig. Sanit., 43, 92-4 (1978); Pesticide Abstr., 790982 (1979). Gia. Sanit., 43, 78-9 (26V) Kucher, A. G , Rakov, A. A., Satmain. D. I., (1978); Pesticide Abstr., 78-2481 (1978). (27V) Kurtz, D.A., NBS Spec. Publ. ( U . S . ) ,579, 19-32 (1979). (28V) LaBel, G. L., Wllllams, D. T., Griffith, G., Benoit, F. M., J . Assoc. Off. Anal. Chem., 62, 241-9 (1979). (29V) Loebering, H. G., Weil, L., Quentin, K. E., Vom Wasser, 57, 265-71 (1978); Pesticide Abstr., 79-1748 (1979). (30V) Lores, E. M., Bristol, D. W., Moseman, R. F., J . Chromatogr. Scl., 76, 358-62 (1978); Pesticide Abstr., 79-0234 (1979). (31V) Lott. P. F., Lott. J. W., Doms, D. J., ibid.. 76, 390-5 (1978); Pesticide Abstr., 79-0235 (1979). (32V) Mallet, V. N., Francoeur, J. M., Volpe, G., J . Chromatogr., 772, 388-93 (1979); Pesticide Abstr., 79-1975 (1979). (33V) Matisova, E., Krupcik. J., Liska, O., ibid., 773, 139-46 (1979); Pesticide Abstr., 79-2244 (1979). (34V) Mindrup, R., Jr., NBS Spec. Publ. ( U . S . ) , 579, 225-9 (1979); Pesticide Abstr., 79-3127 (1979). (35V) Moseman, R. F., Ward, M. K., Crist. H. L., Zehr, R. D.. J. Agric. Food Chem., 2 6 , 965-8 (1978); Pesticide Abstr.. 78-2485 (1978). (36V) Murray, D. A. J., J . Chromatogr., 777, 135-40 (1979); Pesticide Abstr., 80-0281 (1980). (37V) Otsuki, A., Takaku, T., Anal. Chem., 57, 833-5 (1979). (38V) Ragab, M. T. H., Chemosphere, 7 , 143-54 (1978); Pesticide Abstr., 79-0226 119791. .. (39V) Rees: G. A. V., Au, L., Bull. Environ. Contam. Toxicoi., 2 2 , 561-6 (1979); Pesticide Abstr., 79-2812 (1979). (40V) Rogovskiy, D. Y., Minenko, A. K., Pastushenko, T. V., Gig. Sanit., 43, 109-10 (1978); Pesticide Abstr., 79-0983 (1979). (41V) Sackmauerova, M., Kovac, J., Fresenius' Z . Anal. Chem., 292, 414-5 (1978); Pesticide Abstr., 79-2544 (1979). (42V) Scholten, A. H. M. T., Van Buuren, C., Lawrence, J. F., Brinkman, U. A. T., Frei, R. W., J . Liquid Chromatogr., 2 , 607-17 (1979); Pesticide Abstr., 79-1980 (1979).
(43V) Schulten, H. R., Fresenius' 2. Anal. Chem., 293, 273-81 (1978); Pesticide Abstr., 79-1225 (1979). (44V) Schulten, H. R., Stoeber, I., h i d . , 293, 370-6 (1978); Chem. Abstr., 90. 1...~. 5 6 8 2 9 ~11979) (45V) Singh, J., Coch&e, W. P., Scott, J., Bull. Environ. Contam. Toxicol., 2 3 , 470-4 (1979); Pesticide Abstr., 80-0268 (1980). (46V) Smith, S . , Willis, G. H., J . Agric. Food Chem., 2 6 , 1473-4 (1978); Pesticide Abstr., 79-0480 (1979). (47V) Smyth, M. R., Smyth, W. F., Analyst (London), 703, 529-67 (1978). (48V) Soderquist, C. J., Crosby, D. G., Anal. Chem., 50, 1435-9 (1978). (49V) Solomon, J., ibid., 57, 1861-3 (1979). (50V) Stoeber, I., Reupert, R., Vom Wasser, 57,273-83 (1978); Pesticide Absb., 79-1749 (1979). (51V) Sundaram, K. M. S.,Szeto, S. Y., Hlndle, R., J . Chromatogr., 777, 29-34 (1979); Pesticide Absfr., 80-0278 (1980). (52V) Takaku, T., Otsukl, A., Takahashi, M., Bunseki Kagaku, 28, 702-4 (1979); Chem. Absfr., 92, 82073n (1980). (53V) Thompson, K. C., Wagstaff. K., Analyst (London), 704, 668-79 (1979). (54V) Veith, G. D., Austin, N. M., Morris, R . T., Water Res., 73, 43-7 (1979); Pesticide Abstr., 79-1249 (1979). (55V) Yamato, Y., Suzuki, M., Watanabe, T., J . Assoc. Off. Anal. Chem., 67, 1135-9 (1978). (58V) Yamato, Y., Suzuki, M., Watanabe, T., Biomed. Mass Spectrom., 6 , 205-7 (1979); Pesficlde Absb., 79-2539 (1979). (57V) Zakitis, L. H., Bull. Environ. Contam. Toxicol., 2 3 , 391-7 (1979); Pesticide Abstr., 79-3105 (1979). (58V) Zhu, A., Chang, L.. Wu, H., Yang, C., Ho, Y., Huan Ching K ' o Hsueh, 1979, 58-63; Chem. Abstr., 9 2 , 185568e (1980).
.
DETERGENTS (IW) Chleblckl, J., Garncarz, W., Chem. Anal. (Warsaw), 2 4 , 675-81 (1979); Chem. Abstr., 9 2 , 99337w (1980). (2W) Favretto, L., Stancher, B., Tunis, F., Analyst (London), 704, 241-7
.- . -,.
I,I q 7 Q \
(3w) Gagnon, M. J., Water Res., 73, 53-6 (1979); Chem. Abstr., 9 0 ,
158847a 11979). ( 4 W < - H e l k h n , -H., Fresenius's 2. Anal. Chem., 293, 359-63 (1978); Chem. Absb., 90, 127285k (1979). (5W) Hon-Nami, H., Hanya, T., J. Chromatogr., 767,205-12 (1978); Chem. Abstr., 9 0 , 76304f (1979). (6W) Le Bihan, A., Courtot-Coupez, J., Analusis, 6, 346-9 (1978); Chem. Abstr., 9 0 , 15719y (1979). (7W) Otsuki, A., Shiraishi, H., Anal. Chem., 57, 2329-32 (1979). (8W)Yaneva, S., Borisova-Pangarova, R., Taianta, 25, 279-82 (1978). MISCELLANEOUS
(1X) Batley, G. E., Giies, M. S . , Water Res., 73, 879-86 (1979); Chem. Abstr., 92, 820493 (1980). (2X) Boutron, C.,Martln, S., Anal. Chem., 57, 140-5 (1979). (3X) Chakrabarti, C. L., Subramanian, K. S.,Sueiras, J. E., Young, D. J., J. Am. Wafer Works Assoc., 70, 560-5 (1978). (4X) Chatfield, E. J., Glass, R. W., Dillon, M. J., U . S . NTIS, PB Rep. 280783, Avail. NTIS, 132 pp (1978). (5X) Funk, W., Vom Wasser, 4 8 , 75-87 (1977); Chem. Abstr., 8 9 , 117415t (1978). (6X) Garbarino, J . R., Taylor, H. E.,Appi. Specfrosc., 34, 584-90 (1980). (7X) Hall, A., Godlnho, M. C., Anal. Chim. Acta, 773, 369-73 (1980). 18x1 Henriksen. A., Nature(London), 278, 542-5 (1979); Chem. Abstr., 9 7 , 128660m (1979). (9X) Kelr, R. S., Mar. Chem., 8 , 95-7 (1979); Chem. Abstr., 9 2 , 82051d (lox) Mart, L., Fresenius' Z . Anal. Chem., 296, 350-7 (1979); Chem. Absfr., 97, 1628271 (1979). (11X) Mart, L., ibid., 299, 97-102 (1979); Chem. Abstr., 9 2 , 1 5 2 7 2 1 ~ (1980). (12x1 Pakalns. P., Batlev. G. E., Cameron, A. J., Anal. Chim. Acta, 99, ' 333-42 (1978). (13X) Peterson, J. M., Whlte, C. C., Pljanowski, B. S.,Ward, G. K., Report, NOAA- TM-NOS-23, NOAA- 79072307; No. PB- 3007 79, Avall. NTIS, 23 PP (1979). (14X) Shaw, F., Analyst(London), 705, 11-17 (1980). (15X) Taylor, H. E., Erdmann, D. E., Chem., Biomed., and Environ. Instrumentation, 9 , 49-60 (1979).
Clinical Chemistry Merle A. Evenson Department of Medicine and Pathology, University of Wisconsin, 600 Highland Avenue, Madison, Wisconsin 53792
This listin of the literature selects articles from December 1978 througa November 1980. The business of clinical chemistry has become a very large industry in the United States, and the trends in the literature clearly reflect the 214 R
0003-2700/81/0353-214R$06.00/0
commercial interests in this field. In the past 2 years, instrument manufacturers and chemical reagent distributors have started to emphasize the use of the literature as an advertising medium to a much greater extent. The name
0 1981 American Chemical Society
CLINICAL CHEMISTRY A. Evis a RoIesMT in the Dspartments 01 Medicine and PamOlogy-Laboratory Medicine at the University 01 Wisconsin--MadiSon and is also lhe Dksctor 01 me mug and Trace Element Analysis LaboTatories st University Hospitsls. He r e ceived his RID. degee in analytical dwmitry in 1966 from the University of 3 Wisconsin-Madison where he also earned hvo M.S. degree9 in educalion. He has a B.S. degree wlh horns from the University 01 Wisconsin-Lacrosse and has 3 ywrs 01 high school teaching experience. Evenson was Director of lhe Clinical Chemlptv L a b ratwiei at lhe University 01 Wisconsln pria lo his POSlOn as vislling bcturet in B b ~ l C aChemistry l St %Nard Medical SChWl in 1969-1971. Simunaneously. while in Boslon. he was associated w R the Biophysics Research Labastay at lhe Peter B m l Brigham HospllaI. His research interests include the study of swucture-lunctian relationships 01 metalloproteins impwlant in heath and disease. the chemical characterization of uremic toxins. and the development of analytical methods lor drugs and trace elements. His service responsibiliir center around hwe 01 gas Chomatcgaphy. liqUi3 chromatography. and mass spectrometry iw me mntilicalion and quantilalion of drugs and other Substances. Trace metal analyses in his SBNiCe iaboratcq are usually conducted by flame and nonflame atomic absorption spectrometry. He is a former member of the Board 01 Ednas 01 ClinicalChemistry. Chemicsl Inshumentafbn. Selected Melhodr in Clinical Chemisrry. and Ana@Tical Toxkokgy. He has ~ e ~ ae 3-year d term on the advisory board 01 Analyticsl Chemisfry. He was an ediior 01 the series "Contempwary Topics in Analgicai and Clinical Chemistry". He served as chairman of the 1978 &don Research Conference on Anawical Chemistry. He is a Dipiomat in the American Board 01 Clinlcai Chemists. Inc.. and is currently VicepTesidBnt 01 that organization. He has SBN& on various S l d y sections 01 the National lnstltutes of Heah (NIH) and was chalrman of lhe Clinical Toxicology Senion 01 lhe Clinical Chemistry and &matology Medical htvice Panel at the F&rd Drug Administration (FDA). He has s e ~ e das an advisor to the Analytical mioh 01 me Oak REge National LabMstay. He has been actlve in devebping prcqams at Natbnal Meetings for the Analytical Division 01 the A m i c a n Chemical Smlety. He is a member 01 the American Chemical Scciety. the A m i c a n Association lor Clinical Chemistry. Sigma XI. AAAS. and Kappa Deb mi (Honwary E d m tbn Society).
M.M
.T-';\
change of the American Association of Clinical Chemists to the American Association for Clinical Chemistry has produced a major change of emphasis a t the annual meeting of the organization in the past 2 years. The growth and trends in clinical chemistry are likely to continue as long as financial resources are available to support these components of our health care delivery system. Changes in attitudes toward the industry, however, are becoming more ap arent and, in some cases, even a clearer picture for future Bevelopment is visible. Commerical competition in the clinical laboratory market has become fierce in recent years and research costs have even outstripped inflation. Hence, many companies are trying even harder to obtain the maximum financial yield from existing products and are being exceedingly careful about investments in research for the future. This listing of the clinical chemistry literature is intended to allow easy access to some of the root references for those interested in the application of analytical chemistry. Two years ago, the length of the literature listing caused excessive printing expenses to Analytical Chemistry. Thus, a requirement for this issue was to decrease by about one-third to one-half, the number of literature entries from 2 years ago in a field that continues to grow at a rate of 10-20% per year. No reasonable, logical, or feasible way to achieve this space limitation was apparent Hence, this review is caught in a tight bind because of the need for these cost control administrative changes. Articles from journals like Analytical Toxicology, Journal of Chromatographic Science, Journal of Chromatography, Analytical Biochemistr , and other anal ically oriented journals have been excluddfrom this review, ?&awe the contents are covered either by technical or technic reviews elsewhere in this applied review issue or in the fundamental review issue published in alternate years. With apologies to our foreign colleagues in clinical chemistry, this year's listing of literature is principally from Analytical Chemistry and Clinical Chemistry. The hope is that users of this issue will recognize the extreme space constraint and will use this only as a sparse root source of references for the subject for their own interests,
In addition to using only journals published in the United States for this listin several categories of subject matter reviously included %ave been dropped this year. Those Iterature references in the forms of books. reviews, and symposia, medical applications, pesticides and analysis of miscellaneous compounds, editorials, recommendation and opinions as categories have all been eliminated from this review.
INSTRUMENTATION FOR CLINICAL CHEMISTRY The amount of new signifcant instrumental approaches to
clinical analysis is substantidy decreased in this 2-year time period. Perhaps the increased cost of research, increased competition for research grants at universities, and the desire for the companies for cost control of their corporations, in addition to the public demand to contain medical costs, has hit hardest on the technological contribution to the clinical laboratories. Few substantially new ideas and new ap roaches have appeared for instrumentation in the clinical lagoratory during this last 2-year time period. There has been an enormous decrease in the amount of published work on the large high volume process control type of analyzers that have found substantial usage in clinical chemistry. Maybe all of the negative comments about cost effectiveness of screening programs and the threat of third party payers of health care not to pay for unrequested test results, regardless of how efficiently they are done, has led to this decrease in interest in high volume and screening clinical chemistry type instrumentation. The efficiency with which a clinical laboratory test can be performed has become less important to many health care administrators and has perhaps contributed to the decrease in large instrumentation for the clinical laboratories.
METHOD DEVELOPMENTS, SEPARATIONS Several articles in the past 2 years have directed our attention to the inaccuracies of immunochemical tests for clinical chemistry. Other separation methods, such as poly(ethylene glycol) induced rotein precipitation instead of charcoal or a second antih y separation technic has been increasing in the last few years. Further, method development to avoid the use of radiochemical tracers has caused a renewed interest in fluorescent detection. The usual nonideal, noncomplete separations in clinical chemistry coupled with the nonspecific effects of quenching an enhancement of the fluorescence continues to create analytical problems with these new approaches. Hence, a substantial amount has been written in the literature and is directed at these inaccuracies of these new methods. Method develooment for liauid chromatoeraohv (LC) has not developed at'the rate expected, as dic&&d by the LC instrumentation sales in the past few years. Ion- airing chromatography and reverse-phase column materiaE have been unusually slow to offer significantadvantages over other LC methods. In eneral, several practical plumbing type problems and a lac%of accurate methods have controlled the amount of literature in the LC method field.
J
NONAMINO NITROGEN COMPOUNDS, LIPIDS The major emphasis in this area in the past 2 years has been toward the development of standard reference methods of analysis rather than attempted improvement in existing field methods of analysis. Reference methods using liquid chromatography for creatinine, for uric acid. and for hloud urea nitrogen have a eared in the aqt 2 years. In the areas of)lpids, most eft% has been directed toward improved standardivltion of the methods. Inaccuracies of the methods for measuring high and low density lipids, including cholesterol. has heen pointed out by several authors. Again, the emphasis 9eems to he on refinement of technics rather than significant new ad\.ances or new approaches to mea. surements.
PROTEIN CHEMISTRY, IMMUNOCHEMISTRY, ENZYMES, AMINO ACIDS Most of the activity of this section centers on immunochemistry and minor modification of previously published ANALYTICAL CHEMISTRY. VOL. 53.
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methods. A very large percentage of the papers have focused on the inaccuracies of the analytical method when immunochemistry is used and often times the lack of specific patient information obtained from the laboratory test data is pointed out. For example, the enzyme patterns of creatine kinase and the failure of the isoenzyme patterns to accurately indicate cardiac damage have caught the attention of many authors. The literature coverage of protein chemistry and amino acid chemistry focused to clinical chemistry have almost totally been eliminated this time due to space limitations. Most of that type of literature is in the biochemistry research literature and that area has not been included in this listing.
DRUG ANALYSES, TOXIC SUBSTANCE ANALYSIS The ma'or area of emphasis in this category in the past few years has been on therapeutic drug monitoring (TDM). The leader for most methods is perhaps the analysis of the antiepileptic drugs (AED) and theophylline. Analysis of psychotropic drugs including the tricyclics and their metabolites continue to be difficult analytical problems. Further, the clinical correlation of the laboratory results to their patients by the sychiatrists remains less accurate than had been hoped. !'here seems to be a trend away from high technology instrumentation like mass spectrometry and toward immunochemical methods for TDM. And, in similar manner, it seems that the use of high technology for obtaining identification of unknown substances has declined in the last 2 years and that clinical conservatism has reestablished itself as a predominant philosophy in patient poisoning cases.
TRACE ELEMENTS, BLOOD GASES, AND ANIONS Interest in trace elements seems to have moved from the area from health and disease into the area of normal values and nutrition during the past 2 year time period. Multielement analysis using the argon torch as a source for quantitative emission spectrometry, except for the easily done elements, seems to have lost some of its appeal in clinical chemistry. Blood gases and anion clinical chemistry seem to be directed toward improved standardization and to clinical interpretation, respectively, rather than to any substantial analytical advance.
HORMONES, STEROIDS, AND VITAMINS Analysis for hormones using electrochemical technics continues to lead the way in the number of papers. Many method papers were published to improve the accuracy of methods currently in use. The commerical interest in producing kits that require a minimum of expertise for the operators and a minimum amount of instrumentation was the common theme for these type of methods papers in the past 2 years. There seems to be a declining interest in steroids and vitamins in the field of clinical chemistry.
CARBOHYDRATES AND ORGANIC ACIDS A few papers were published on modified methods of sol-
vent extractions and derivative formation prior to gas chro!natog;raphy-mass spectrometry of organic acids usually found 111 urine. Some analytical efforts were directed at some sugars other than glucose in attempts to apply these analytical results to microbiological problems in humans and well as the mental health problems.
METHOD EVALUATIONS, QUALITY ASSESSMENT AND STATISTICAL STUDIES, SAMPLING The largest amount of activity in this category was in pointing out the inaccuracies, flaws, and needs for improvement of analytical methods. Frequently, two instrumental methods are compared and usually the most recent method was judged to be superior to the older method. There was a si nificant increase in interest in quality assessment and quayit control in this past 2 years. The statistical studies have gecome much more mathematically sophisticated. Perhaps, because of the increased interest in quality of results and the need for increased accuracy, the collection of proper samples has received more attention. More efforts on sampling can be expected in the near future. 216R
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ANALYSES FOR SPECIFIC DISEASES, SAFETY, OTHER Continuing attempts to have the laboratory results be more accurate in disease detection, disease prognosis, and success of therapy continue to fall far short of hopes. The examples of creatine kinase, isoenzymes in cardiac incidents, the high-density cholesterol and enzyme profiles are all examples of clinical disappointment with laboratory results. The unavoidalbe observation is that laboratory information done and by itself is not as valuable as hoped but must be fitted into a cherent, consistent, and logical pattern that engulfs the whole patient and includes all influences on that patient. Much work in analytical chemistry directed toward clinical chemistry remains for us all. LITERATURE CITED 1NSTRUMENTATIONFOR CLINICAL CHEMISTRY
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(998) Tsang, V. C. W., Wilson, B. C., Maddison, S. E., Kinetic Studles of a Quantitative Single-Tube Enzyme-Linked Immunosorbent Assay. Clin. Chem., 26, 1255 (1980). (1008) van Buuren, C., Lawrence, J. F., Brinkman, U. A. Th., Honlgberg, I. L., Frel, R. W., Reversed-Phase Liquid Chromatography of Basic Drugs and Pesticides with a Fluorigenlc Ion-Pair Extraction Detector. Anal. Chem., 52, 700 (1980) (101B) Veazey, R. L., Nleman, T. A., Chemiluminescent Determination of Clinically Important Organic Reductants. Anal. Chem., 51, 2092 (1979). (1028) Virella, G., Munoz, J. Lopes-Virella, M. F., Ward, B., Gadsden, R., Rapid Immunochemical Determination of Free Hemoglobln in Plasma and Urine with a Laser Nephelometer. Clin. Chem., 25, 497 (1979). (1038) Wagner, 0 , Alspector, B., Feingers, J., Pick, A,, Direct Radiolmmunoassay with Caplllary Chromatography Tubes. Clln. Chem., 25, 1337 (1979). (1048) Wagner, R. S., Charles, B. G., Lach, J. L., Isolation of 6-Demethylgrlseofulvin from Urine. Clin. Chem , 26, 363 (1980). (1058) Walsh, R. L., Coles. M E., Geary, T. D.,Evaluation of Two Commercially Available Laser Nephelometers and Thelr Recommended Methods for Measurement of Serum lmmunogiobulin G. Clln. Chem., 25, 151 (1979). (106B) Ward, M. W. N., Owens, C. W. I., Rennie, M. J., Nitrogen Estimatlon in Biologlcal Samples by Use of Chemlluminescence. Clin. Chem., 28, 1336 (1980). 1078) Warren, K., Kubaski. N P., Brody, E. E., Sine, H. E., D'Souza, J. P., The Multilayered Film Analyzer: Glucose in Serum, Plasma, Cerebrospinal Fluid and Urine: and Urea Nltrogen in Serum and Plasma. Clin. Chem., 26, 133 (1960). l08B) Wease. D. F., Simplified Aseptic Separatlon of Cells and Plasma. Clln. Chem., 25, 490 (1979). 109s) Weller. E. W., Zenk, M. H., Iodinated Digoxin Derlvatlves with Improved Reactivity and Stability, for Use in Radioimmunoassay. Clin. Chem., 25, 44 (1979). I105) Weissman, E. B., Carcinoembryonic Antigen Assayed by Column Chromatography on Polyacrylamide Gel. Clln. Chem., 26, 770 (1980). (1 1lB) Wenz, B., Feng, C. S., Karmen, A,, Kmproved Method for Detectlng Hemagglutination by Centrifugal Analysis. Clin. Chem., 25, 1613 (1979). (1128) Werner, M., Mohrbacher, R. J., Riendeau, C. J., Murador, E., Cambiaghi, S., Immoblllzed Enzymes in Continuous-Flow Anaiysis. Clin. Chem., 25, 20 (1979). (1 135) Whltehead, T. P., Kricka, L. J.. Carter, T. J. N., Thorpe. G H G.. REVIEW: Analytical Lumlnescence: Its Potential in the Clinlcal Laboratory. Clin. Chem., 25, 1531 (1979). (1148) Whitehouse. L. W., Paul, C. J,, Micro-Scale Enzymlc Determinatlon of Ethanol in Plasma with a Discrete Analvzer. the ABA-100. Clin. Chem.. 25, 1399 (1979). (1158) Wilding, P., Bullock, D. G., Kricka, L. J., Morriss, P., Holder, R. L., Spectral Analysis of Urlnary Reactlons: A Preilmlnary Study Based on a Novel Concept. Clin. Chem.. 25, 476 (1979). (116B) Wu, J. 1..Wu, L. H., Zlter, F. A,, Ash, K. O., Manual Flurometry of Phenylalanine from Blood Specimens Collected on Fllter Paper: A Modified Procedure. Clln. Chem., 25, 470 (1979). (1178) Wu, T.-W., Zumbulyadls, N., Gross, S., Gohlke, R. S.,Human Conjugated Blilrubln-Isolation. Biosynthesis, and Direct Molecular Characterlzatlon, Clln. Chem., 26, 1323 (1980), (1185) Yanagibashi, K., Mizuchi, A., Yotsumoto, H., Mlyachi, Y., Separation of Serum Prednlsoione and Prednisolone-21-Hemisuccinate by Extraction and Their Concurrent Determination by Radioimmunoassay. Clin. Chem., 26, 1301 (1980). (1198) Yoder, J. M., A Sensitive Type of "Immunocapillary Migration" Assay That Detects Insulin. Clln. Chem., 25. 814 (1979). (1208) Zuk, R. F., Rowley. 0. L., Wllman. E. F., Fluorescence Protection Immunoassay: A New Homogeneous Assay Technique. Clin. Chem., 25, 1554 (1979). NONAMINO NITROGEN COMPOUNDS, LIPIDS
(1C) Abele, J., Khayam-Bashi, H.. Aqueous Primary Standard for Use In Measurlng Cholesterol by the Cholesterol Oxidase Method. Clln. Chem., 25, 132 (1979). (2C) Ablln, R. J., Aiteratlons of Serum Glycoprotelns--Possible Biologic Markers of Tumor-Host Responsiveness, (Reply). Silverman, L. M., Dermer, G. 8. Clin. Chem., 25, 807 (1979). (3C) Aguzzl, F., Paggi, N., Maggi, M., Some Data on Intra-Indivldual Varlability In High-Density-Lipoprotein Cholesterol. Clln. Chem., 25, 1671 (1979). (4C) Allen, J. K., Hensley, W. J., Nlcholis, A. V., Whitfleld, J. B., An Enzymlc and Centrifugal Method for Estimating High-Density Llpoproteln Cholesterol. Clin. Chem., 25, 325 (1979) (5C) Allen, J. K., Whitfleld, J, B,, Polyethylene Glycol Method for High-hnslty Lipoprotein Cholesterol Defended. Clln. Chem., 25, 1346 (1979). (6C) Anaokar, S,, Garry, P. J., Standefer, J. C., Enzymic Assay for Leclthln in Amniotic Fluid. Clin. Chem., 25, 103 (1979). (7C) Anderson, G. M., Purdy, W. C., Liquld Chromatography-FlurometricSystem for the Determination of Indoles In Physiological Samples. Anal. Chem., 51, 283 (1979). (8C) Annoni, G., Dioguardl, M. L., Trlpodl. A,, Zuln, M., Enzymic Assay of Choline-Containing Phosphollplds in Bile. Clln. Chem , 26, 669 (1980). (9C) Ash, K. Q., Hentschei, W. M., High-Denslty Lipoproteins Estlmated by an Enzymatic Cholesterol Procedure, with a Centrifugal Analyzer. Clin. Chem.. 24, 2180 (1978). (1OC) Balille, E. E., Orr, C, W., Lowered HighDensity-Llpoproteln Cholesterol in Viral Illness. Clin. Chem., 25, 817 (1979). (1 IC) Baillie, E. E.,Welborn. P., HIII, J., Sexton, B., Cholesterol In High-Density Lipoprotelns Quantlfied by Agarose Gel Electrophoresis, Cellulose Acetate Electrophoresis, and Magnesium-Sodium Phosphotungstate P r e cipitation. Clin. Chem , 26, 679 (1980).
CLINICAL CHEMISTRY (12C) Banda, P. W., Tuttle, M. S., Sherry, A. E., Blols, M. S., Total Creatinlne Content of the First Morning Urine Is Independent of Dietary Change. Clln. Chem., 26, 535 (1980). (13C) Behner, E. D., Hubbard, R. W., Amperometric Liquid Chromatography of Catecholamines. Clln. Chem., 25, 1512 (1979). (14C) Berde, C. B., Kerner, J. A., Johnson, J. D., Use of the Conjugated Polyene Fatty Acid, Parinaric Acid, In Assaying Fatty Acids in Serum or Plasma. Clh. Chem., 26, I173 (1980). (15C) Berglund, G., Greter, ,I., Lindstedt, S.. Steen, G., Waldenstrom, J.. Wass, U., Urinary Excretion of Thymlne and Uracil in a Two-Year-Old Child with a Malignant Tumor of the Brain. Clln. Chem., 25, 1325 (1979). (16C) Bergman, A,, Ohman, Ci., Effect of Detergent on Kinetic JaffB-Method Assay of Creatlne. Clin. Chem., 26, 1729 (1980). (17C) Blumenfeld, T. A., Cheskin, H. S., Shinitzky, M., Microviscosity of Amniotic Fluid Phospholipids, aind Its Importance in Determining Fetal Lung Maturity. Clin. Chem., 25, 64 (1979). (18C) Bryson, G., Biogenic-Amine Determinatlon and Liquid Chromatography Readout: Fluorescent vs. Electrochemical Detection. Clin. Chem., 25, 1188 (1979). (19C) Cheskin, H. S., Blumenfeld, T. A., Beers, P. C., Buddega, V., Effect of Gestational Variation of Phosphatidylglycerol and Phosphatidylinositol on the Microviscosity of Amniotic Fluid Phospholipids. Clin. Chem., 26, 301 (1980). (20C) Cline, L. J., Crowle, A. J.,k Identiflcatlon of a,-Lipoproteins in Crossed Immunoelectrophoresis. Clln. Chem., 25, 1749 (1979). (21C) Cohen, A., Hertz, H. S., Mandel, J., Pauie, R. C.,Schaffer, R., Sniegoski, L. T., Sun, T., Welch, VI. J., White, E. V., Total Serum Cholesterol by Isotope DllutionlMass Spectrometry: A Candldate Definitive Method. Clin. Chem., 26, 854 (1980). (22C) Conlon, D. R., Blankstein, L. A., Pasakarnis, P. A., Steinberg, C. M., D'Amelio, J. E., Quantitative Determination of Hlgh-Density Lipoprotein Cholesterol by Agarose Gel Electrophoresis. Clh. Chem., 25, 1965 (1979). (23C) Crowell, M. J., Macdonaild, I. A., Enzymic Determination of 3&, 7&, and 12fi-Hydroxyl Groups of Fecal Bile Salts. Clln. Chem., 26, 1298 (1980). (24C) Davies, C., Fahie-Wilson, M. N., Use of Magnesium Acetate In HighDensity Lipoprotein Cholesterol Assay. Clln. Chem., 25, 1510 (1979). (25C) Deacon, A. C., Dawson, P. J. G., Enzymic Assay of Total Cholesterol Involving Chemical or Enzymic Hydrolysls--A Comparison of Methods. Clin. Chem., 25, 976 (1979). (26C) Dorwart, W. V., Bilirubin Interference in Kinetic Creatinine Determination. Cllfl. Chem., 25, 196 (1979). (27C) Duck-Chong. C. G., Gupta, J. M., Storey, G. N. B., Houghton, C. R. S., Lamellar Body Phospholipid Content of Amniotlc Fluid and L/S Ratio Compared in Assessing Fetal Lung Maturity. Clin. Chem., 26, 766 (1980). (28C) Eastman, J. R., Bixler, D., Urinary Phosphoethanolamine: Normal Values by Age. Clin. Chem., 26, 1757 (1980). (29C) Fossati, P., Prencipe, l..,Berti, G., Use of 3,5-Dlchloro-2-hydroxybenzenesulfonic Acid/4-Amiiiophenazone Chromogenic System In Direct Enzymic Assay of Uric Acid In Serum and Urine. Clin. Chem., 26, 227 (1980). (30C) Fujita, K., Nagatsu, T., Shlnpo, K., Maruta, K., Teradaira, R., Nakamura, M., Improved Analysis for Urinary Polyamines by Use of High-Voltage Electrophoresis on Paper. Cbn. Chem.. 26, 1577 (1980). (31C) Gabor, J., Spain, M., Kalant, N., Composition of Serum Very-Low-Densky and Hlgh-Density Lipoproteins in Diabetes. Clin. Chem., 26, 1261 (1980). (32C) Glick, M. R., Moorehead, MI. R., Oei. T. O.,Moore, 0. R., Acetoacetate and "Ketone" Interference in Kinetic and Continuous-Flow Methods for Creatinine, (Reply), North, J. VV. Clln. Chem., 26, 1626 (1980). (33C) Greter, J., Lindstredt, S., Seeman, H., Steen, G., 3-Hydroxydecanedloic Acld and Related Homologues" Urinary Metabolites In Ketoacidosis. Clln. Chem., 26, 261 (1980). (34C) Grove, T. H., Effect of Reagent pH on Determination of Highdensity Lipoprotein Cholesterol by Preclpitation with Sodlum PhosphotungstateMagnesium. Clh. Chem., 25, 560 (1979). (36C) Hahn, Y., Olson, C. L., Arnperometric Enzymatic Determination of Total Cholesterol in Human Serum with Tubular Carbon Electrodes. Anal. Chem., 51, 444 (1979). ( 3 6 0 Haworth, J. K., Kruski, A. W., Stern, M. P., Heparln-MnCI, vs. Dextran Sulfate-CaCI, Precipitation of Lipoprotein from Human Serum. Clln. Chem., 25, 2050 (1979). (37C) Jennings, C., Weaver, D. Id., Kruski, A. W., Effects of Freeze-Thawing on Determlnations of Cholesterol and High-Density Llpoprotelns in Baboon Sera. Clin. Chem., 25, 490 (1979). (38C) Jones, K. G., Sweeney, G. D., Quantiation of Urinary Porphyrins by Use of Second-Derivative Spectroscopy. Clin. Chem., 25, 71 (1979). (39C) Jury, D. R., Ward, R., Laboratory-Prepared Reagent for the Beckman Creatinlne Analyzer. Clln. Chom., 25, 1674 (1979). (40C) Kaplan, E., Finkle, H. I., Factitious Hyperuricemia Caused by AboveNormal Globulins. Clln. Chem., 26. 1106 (1980). (41C) Kennedy, J. H., Semmence, A. M., Xanthlnuria: A New Case. Clln. Chem., 26, 1758 (1980). (42C) Kollns, M. D.,Epsteln, E , Clvin, W. H., Weiner, S., Amnlotic Fluid' Phospholipids Measured by Continuous-Development Thin-Layer Chromatography. Cllfl. Chem., 26. 408 (1980). (43C) Kostner, G. M.. Avogaro, P , Bon. G. B., Cazzolato, G., Quinci, G. B., Determinatlon of High-Density Lipoproteins: Screening Methods Compared. Clh. Chem., 25, 939 (1979). (44C) Kruski, A. W., Weaver, D. M., Separatlng Lipoproteins In 50 fiL of Serum: Heparln-MnCI, and Dextran Sulfate-CaCI, Procedures Compared. Cllfl. Chem., 26, 1103 (1980). (46C) Kuba, K., Lippel, K., F r a n k I. D.,Jr., Four Electrophoretic Methods Compared for Diagnosis of Type 111 Hyperllpoproteinemla. Clln. Chem., 25, 1471 (1979).
(47C) Kupke, I. R., Zuegner, S., Gottschalk, A,, Comparlson of Two Micromethods for Determination of Lipoprotein Cholesterol in Plasma. clin. Chem., 25, 1795 (1979). (48C) Labbe, R. F., Finch, C. A., Smith, N. J., Doan, R. N., Sood, S. K., Madan, N., Erythrocyte Protophorphyrin/Heme Ratlo in the Assessment of Iron Status. Clin. Chem., 25, 87 (1979). (49C) Lewis, L. A., Naito, H. K., REVIEW: Relation of Hypertension, Lipids, Lipoproteins to Atherosclerosis. Clin. Chem., 24, 2081 (1978). (50C) Liedtke, R. J., Kroon, G., Batjer, J. D., Enzymic High-Density Lipproteln Cholesterol Analysis: Effects of Manganese. Cllfl. Chem., 26, 1755 (1980). (51C) Lopes-Virella, M. F. L., Virella, G., Evans, G., Malenkos, S. B., Colwell, J. A,, Immunonephetometric Assay of Human Apolipoprotein A l . Cllfl. Chem., 26, 1205 (1980). (52C) MacAulay, M. A., Jacklyn, C. L., Mathers, J. M., Storm, V. A,, Continuous-Flow Enrymatlc Determination of Total Serum Cholesterol and Method Standardization with CDC-Calibrated Pooled Sera. Cllfl. Chem., 26, 696 (1980). (53C) Maentausta, O., Janne. O., Radioimmunoassay of Conjugated Cholic Acld, Chenodeoxycholic Acid, and Deoxycholic Acid from Human Serum, with Use of 1251-labeledLigands. Clln. Chem., 25, 264 (1979). (54C) Mao, S. J. T., Kottke, B. A., Determination of High-Density Lipoprotein Cholesterol by Heparin-MnCi, Precipitation. Clin. Chem., 26, 1369 (1980). (55C) Martin-Ponthleu. A., Porchet, N., Fruchart, J.-C., Sezille, G., Dewailly, P., Codaccloni, X., Delecour, M., Determination of Amnlotic Fluid Phospholipids by Thin-Layer Chromatography, with Use of a Hydrogen Flame Ionization Detector. Clh. Chem., 25, 31 (1979). (56C) Mayfield, C., Warnick, G. R., Albers, J. J., Evaluation of Commerclal Heparin Preparations for Use in the Heparin-Mn" Method for Measuring Cholesterol in High-Density Lipoprotein. Clin. Chem., 25, 1309 (1979). (57C) Meiattinl, F., Prencipe, L., Bardelli, F., Gianninl, G., Tarli, P., The 4Hydroxybenzoate/4-Aminophenazone Chromogenic System Used In the Enzymic Determlnatlon of Serum Cholesterol. Clin. Chem., 24, 2161 (1978). (58C) Meli, L. D., Jr.. Separation of Blogenlc Amlnes by Use of ReversedPhase Liquid Chromatography and Fluorescent Detection. Clln. Chem., 25, 1167 (1979). (59C) Mitnick, M. A., De Marco, B., Gibbons, J. M., Amniotic Fluid Phosphatidylglycerol and Phosphatidylinositol Separated by Stepwise-Development Thin-Layer Chromatography. Clin. Chem., 26, 277 (1980). (60C) Muskiet, F. A. J., de Bruyn, H. W. A,, Hulsjes, H. J., Intrauterine Growth Retardation and Catecholamine Metabolites In Amniotic Fluld. C/h. Chem., 25, 810 (1979). (81C) Muskiet, F. A. J., Thomasson, C. G., Gerding, A. M., Fremouw-Ottevangers, D. C., Nagel, G. T., Wolthers, B. G., Determination of Catecholamines and Their 3-0-Methylated Metabolites in Urine by Mass Fragmentography with Use of Deuterated Internal Standards. Clln. Chem., 25, 453 (1979). (62C) Naito, H. K., Mackenzie, A. H., Secondary Hypertriglyceridemia and Hyperlipoproteinemia in Patients with Primary Asymptomatic Gout. Clin. Chem., 25, 371 (1979). (63C) Narayanan, S., Appleton, H. D., Creatinine: A Revlew. Clln. Chem., 26, 1119 (1980). (64C) Natelson, S., Tseng, H.-Y., Sherwin, J. E., On the Biosynthesis of Guanldinosucclnate. Clln. Chem., 24, 2106 (1978). (65'2) Noma, A., Okabe, H., Netsu-Nakayama, K., Ueno, Y., Shinohara, H., Improved Method for Simultaneous Determination of Cholesterol in Highand Low-Density Lipoproteins. Clin. Chem., 25, 1480 (1979). (86C) Ojala, K., Weber, T. H., Some Alternatives to the Proposed Selected Method for "Agarose Gel Electrophoresis", (Reply), Jeppsson, J.-O., Laurell. C.-B. Clln. Chem., 26, 1754 (1980). (67C) Okabe, H., Uji, Y., Nagashlma, K., Noma, A., Enzymic Determinatlon of Free Fatty Acids in Serum. Clh. Chem., 26, 1540 (1980). (68C) Palnter, P. C., Simultaneous Measurement of Lecithin, Sphingomyelin, Phosphatldylglycerol, Phosphatldylinosltol, Phosphatidylethanolamine, and Phosphatidylserine In Amniotic Fluid. Clln. Chem., 26, 1147 (1980). (69C) Papadopoulos, N. M., Abnormal Lipoprotein Patterns in Human Serum as Determined by Agarose Gel Electrophoresis. Clln. Chem., 25, 1885 (1979). (70C) Peake, M. J., Sontrop, M. E., Frawer, C. G., Trlglycerides Kit Assessment Unfairly Critized? Clln. Chem., 25, 641 (1979). (71C) Pratt, J. J., Ultrafiltration as a Method for Sample Preparation, with Special Reference to Urate. Clln. Chem., 26, 1764 (1980). (72C) Rockerbie, R. A., Dodson. R. D., Frohiich, J., Gas-Chromatographylc Analysis of Patterns of Fatty Acids of Cholesteryl Esters and Phosphatidylcholine. Clln. Chem., 25, 1411 (1979). (73C) Roda, A., Roda, E., Aldini, R., Capelli, M., Festi, D., Sama, C., Mazzella, G., Morselli, A. M.. Barbara, L., Results with Six "Kit" Radloimmunoassays for Prlmary Bile Acids in Human Serum Intercompared. Clln. Chem., 26, 1677 (1980). (74C) %Iti, I. S., Hemady, K., Thiazldes Do Not Affect Xanthine Excretion in Hereditary Xanthinurla. Clh. Chem., 26, 793 (1980). (75C) Schwertner, H. A., McLaren, R. C., Arnold, E. G., Increased Concentrations of Free Fatty Acids and Glycerol and Altered Creatine Kinase MM Isoenzyme Patterns in Certaln Diabetic Patients. Clln. Chem., 25, 520 (1979). (76C) Scottollnl, A. G., Bhagavan, N. V., Oshlro. T. H., Abe. S. Y., Serum High-Denslty Lipoproteln Cholesterol Concentrations in Hypo- and Hyperthyroidism. Clh. Chem., 26, 584 (1980). (77C) Sehgal, H. L., Sehgal, L. R., Rosen. A. L., Gould, S. A., Dalton, L., Moss, G. S., Determlnation of Serum Creatinine in the Presence of Hlgh Concentrations of Free Hemoglobin. Clh. Chem., 26, 1756 (1980). (78C) Shlba, K., Umezawa, Y., Watanabe, T., Ogawa, S.,Fujiwara, S.,ThinLayer Potentiometric Analysis of Llpid Antigen-Antlbody Reactlon by Tetrapentylammonium (TPA') Ion Loaded Liposomes and TPAt Ion Selective Electrode. Anat. Chem., 52, 1610 (1980). ANALYTICAL CHEMISTRY, VOL.
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CLINICAL CHEMISTRY (79'2) Shihabi, 1.K., White, J. P., Liquid-Chromatographic Measurement of Taurine in Cerebrospinal Fluid of Normal Individuals and Patients with Meningitis. Ciin. Chem., 25, 1368 (1979). (80C) Shipe, J. R., Jr., Hunt, D. F., Savory, J., Plasma Polyamines Determined by Negative-Ion Chemical Ionization/Mass Spectrometry. Clin. Chem., 25, 1564 (1979). (81C) Shuli, 8. C., Lees, H., Li, P. K., Mechanism of Interference by Hemoglobin in the Determination of Total Bilirubln. I. Method of Malloy-Evelyn. Clin. Chem., 26, 22 (1980). (82C) Shull, B. C., Lees, H.. Ll, P. K., Mechanlsm of Interference by Hemoglobin in the Determination of Total Bilirubin. 11. Method of JendrassikGrof. Clln. Chem., 26, 26 (1980). (83C) Slaunwhite, D., Tuggey, R., Clements, J., Acetic Acid Interference with Determination of 5-HydroxyindoleacetIc Acid. Clh. Chem., 26, 1754, (1980). (84C) Sinlth, A., Brown, P., Crockett, H., Ash, K. O., Simple Adaptation of the DuPont aca to Allow High-Density Lipoprotein Cholesterol Determination. Clin. Chem., 26, 1373 (1980). (85C) Smith, L., Lucas, U.,Lehnus, G., Automated Measurement of Total Cholesterol and Triglycerides, in "Tandem", on the Discrete Sample Analyzer, Gilford System 3500. Clin. Chem., 25, 439 (1979). (86C) Spierto. F. VV., MacNeii, M. L., Culbreth, P., Duncan, I., Burtis, C. A,, Development and Validation of a Liquld-Chromatographic Procedure for Serum Creatinine. Clh. Chern., 26, 286 (1980). (87'2) Srinivasan, S. R., Foster, T. A., Berenson, G.S., Efficacy of a Slmplified Primary Screening Procedure for Detection of Hyperlipoproteinemias in a Pediatric Population. Clin. Chem., 25, 242 (1979). (88C) Srinivasan, S. R., Foster, T. A., Berenson, G. S., Comparability of Results by Simplified Methods for Measuring Serum Llpoproteln Cholesterol in a Pediatric Population. Clln. Chem., 26, 1548 (1980). (89C) Stein, E. A., McNeely, S., Steiner, P., Electrophoretic Separation of High-Density Lipoprotein Cholesterol Evaluated and Compared with the Modified Lipid Research Clinic Procedure. Clin. Chem., 25, 1934 (1979). (90C) Steinmetz, J., Panek, E., Slest, G., Gueguen, R., Factors Affecting the Concentration of Triacylglycerols (Triglycerides) in Plasma: Reference Values for Adults. Clin. Chem., 25, 924 (1979). (91C) Stepastchuk, L., Avoiding Xanthlne Interference in Urate Determination. Ciln. Chem., 26, 789 (1980). (92C) Stone, W. J., McKinney, T. D., Warnock, L. G., Spurlous Hyperbilirubinemia In Uremic Patients on Propranolol Therapy. Clin. Chem., 25, 1761 (1979). (93C) Sykes, A., Chard, T., Two-Site Irnmunofiuorometric Assay for Pregnancy-Specific @,-Glycoprotein (SP,). Clln. Chem., 26, 1224 (1980). (94'2) Tarantino, M., Segat-Besta, E., Longhi, E., Technique for Separating 0-Llpoprotein as a Distinct Band in the Serum-Protein Electrophoretic Pattern on a Cellulose Acetate Strip. Clin. Chem., 26, 1364 (1980). (9%) Tsai, M. Y., Marshall, J G., Phosphatldylglycerol in 261 Samples of Amniotic Fluid from Normal and Diabetic Pregnancies, as Measured by One-Dimensional Thin-Layer Chromatography. Clln. Chem., 25, 682 (1979). (96C) Ullman, M. D., Pyeritz, R. E., Moser, H. W., Wenger, D. A., Kolodny, E. H., Application of "High-Performance" Liquid Chromatography to the Study of Sphingolipidoses. Clln. Chem., 26, 1499 (1980). (97C) van Voorst tot Voorst, E. J. G. M.,Effects of Centrifugation, Storage, and Contamination of Amniotlc Fluid on Its Total Phospholipid Content. Clln. Chem., 26, 232 (1980). (98C) Warnick, G. R., Albers, J. J., Leary, E. T., HDL Cholesterol: Results of Interlaboratory Proficiency Tests. Clln. Chem.. 26, 169 (1980). (99C) Warnick, 0. R., Cheung, M. C., Aibers, J. J., Comparison of Current Methods for High-Density Lipoproteln Cholesterol Quantitation. Clin. Chern., 25, 596-(1979). (10OC) Warnick, G. R., Mayfieid, C., Albers, J. J., Hazzard, W. R., Gel Isoelectric Focuslng Method for Specific Diagnosis of Familial Hyperlipoproteinemia Type 3. Clin. Chem., 25, 279 (1979). (101C) Wennberg, R. P., Rasmussen, L. F., Ahlfors, C. E.,Valaes, T., Mechanized Determination of the Apparent Unbound Unconjugated Bilirubin Concentration in Serum. Clln. Chem.. 25, 1444 (1979). (102C) Whitehead, T. P., Bullock, D. G., Carter, T. J. N., High-Density Lipoproteln Cholesterol Analysis, (Replies), Ash, K. W., Hentschel, W. M., Cooper, G. R., Mainline, A,, Jr., Miller, D. T., Bayse, D. D. Clin. Chem., 25, 2055 (1979). (103C) Winartasaputra, H., Mallet, V. N., Kuan, S. S., Guilbault, 0. C., Fluorometric and Colorimetric Enzymic Determination of Trlglycerides (Triacyiglycerols) in Serum. Clln. Chem., 26, 613 (1980). (104C) Wood, P, D., Bachorik, P. S., Albers, J. J., Stewart, C. C., Winn, C., Llppel, K., Effects of Salriple Aging on Total Cholesterol Values Determined by the Automated Ferric Chloride-Sulfuric Acld and LiebermannBurchard Procedures. Clin. Chem., 26, 592 (1980). (105C) Worth, H. G. J., Wright, D. J., Assessment of Fetal Lung Maturity by Colorimetric Phospholipld Determination without Digestion. Clln. Chem., 25, 793 (1979), (lO8C) Wung, W. E., Howell, S. B., Simultaneous Liquid Chromatography of 5-Fluorouracil, Uridine, Hypoxanthine, Xanthine, Uric Acld, Allopurinol, and Oxipurinol in Plasma. Clin. Chem., 26, 1704 (1980). (107C) Yamaguchi, Y., Deterrninatlon of High-Density Lipoprotein Phosphoiiplds In Serum. CXn. Chem., 26, 1275 (1980). (lO8C) Zoppi, F., Fenlli, D., Marcovina, S., Peracino, A., Aldehyde Dehydrogenase Interference in the Haeckel Enzymlc Technique for Uric Acid Determination. Clln. Chem., 26, 178 (1980). PRQTEIM CHEMISTRY, IMMUNOCHEMISTRY, ENZYMES, AMINO ACIDS ( l a ) Ablin, R. J., Prastate-Specific Acid Phosphatase, (Reply), Grlttiths. J. C. Clin. Cham., 26, 1632 (1980). 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22QR * AB.IAbYTICAL CHEMISTRY, VOL. 53, NO. 5, APRIL 1981
(3D) Aguzzi, F., More on a,-Globulin Zone-Splitting Phenomenon. Clln. Chem.. 26. 783 (19801. (4D) AI-Dujaili, E. A: S., Forrest, G. C., Edwards, C. R. W., Landon, J., Evaluation and Application of Magnetizable Charcoal for Separatlon in Radioimmunoassays. Clln. Chem., 25, 1402 (1979). (5D) Alayoff,,A, Kapitulnik, J., Konljn, A., Kaufmann, N. A,, Blondhelm, S. H., Bilirubin Binding Capacity of Albumln Isolated from Cord-Blood Serum is Less Than That from Serum of Adults. Clln. Chem., 26, 738 (1980). (6D) Alexander, P. W., Shah, M. H., Automated Continuous-Flow Determination of Serum Albumin by Differential Pulse Polarography. Anal. Chem., 52, 1896 (1980). (7D) Alexander, R. L., Jr., Case Report: Changes in Creatlne Kinase Isoenzymes after Myocardial Infarction in a Patient wlth Prostatlc Carcinoma. Clln. Chem., 26, 661 (1980). (ED) Aleyasslne, H., Giycosylation of Hemoglobin S and Hemoglobin C. Clln. Chem., 26, 526 (1960). (9D) Aleyassine, H., Low Proportions of Giycosylated Hemoglobin Associated wlth Hemoglobin S and Hemoglobin C. Clln. Chem., 25, 1484 (1979). (10D) Ambler, J., Walker, G., Isoelectric Focusing of Serum Proteins on Modified Thin Cellulose-Acetate Membranes. Clln Chem., 25, 1320 (1979). (11D) Anaokar, S., Garry, P. J., Standefer, J. C., Solid-Phase Enzyme Immunoassay for Serum Ferritin. Clln. Chem., 25, 1426 (1979). 12D) Anderson, J. L., Clrculating, Long-Optical Path, Thin-Layer Eiectrochemical Cell for Spectroelectrochemical Characterization of Redox Enzymes. Anal. Chem., 51, 2312 (1979). 13D) Anderson, N. G., Anderson, N. L., Tollaksen, S. L., Proteins of Human Urine. I.Concentration and Analysis by Two-Dimenslonal Eiectrophoresls. Clln. Chem., 25, 1199 (1979). 14D) Arnold, M. A., Rechnltz, G. A., Comparlson of Bacterial, Mitochondrial, Tissue, and Enzyme Biocatalysts for Glutamine Seiectlve Membrane Electrodes. Anal. Chem., 52, 1170 (1980). 15D) Bails, R., Edwards, J. B.. Alcohol Dehydrogenase Interference in Lactate Dehydrogenase Assay. Clln. Chem., 26, 525 (1980). l8D) Bajema, L. L., Lee, W., Zebelman, A. M., Kenny, M. A., DetergentContaining Glucose Oxidase Reagent for Use with the Beckman Glucose Analyzer. Clln. Chem., 25, 127 (1979). (17D) Bauer, K., Bayer, P. M., Deutsch, E., Gabl, F., Binding of Enzyme-IgG Complexes in Human Serum to Protein-A Sepharose CL-4B. Clln. Chem., 26, 297 (1980). (18D) Bayer, P. .M., Unger, W., Gergely, T. W. J., Gabl, F., Activity of Acid Phosphatase in Infancy and Childhood. Clln. Chem., 24, 2207 (1978). (19D) Bee, D. E., James, G. P., Paul, K. L., Hemoglobinuria and Hematuria: Accuracy and Precision of Laboratory Diagnosis. Clln. Chem., 25, 1696 (1979). (20D) Bernstein, R. E., Glycosylated Hemoglobins: Hematologic Considerations Determine Which Assay for Giycohemoglobln Is Advisable. Ciin. Chem., 26, 174 (1980). (21D) Blecher, M., REVIEW Cell-Surface Receptors in Health and Disease. ' ciin. 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(33D) Brooker, G., Murad, F., Automated "Gamma-Flo" Radioimmunoassay of Urinary Cyclic AMP. Clln. Chem., 26, 1738 (1980). (34D) Brosious. E. M., Wright, J, M., Balne, R. M., Schmidt, R. M., Micrcchromatoaraohic Methods for Hemoglobln AI Quantitatlon Compared. Clln. Chek.,' 24. 2196 (1978). (35D) Buffone, G. J., Brett, E. M.. Lewis, S. A., Iosefsohn, M., Hicks, J. M., Limitations of Immunochemical Measurement of Ceruloplasmin. C/;n. Chem., 25, 749 (1979). (36D) Buffone, G. J., Lewis, S. A., Manual Immunochemical Nephelometrlc Assays for Serum Immunoglobulins IgG, IgA, and IgM. Clln. Chem., 25, 1009 (1979). (37D) Burgett, M. W., Ervin, K., Kwan, S., Peasley, B., Response of Creatine Kinase Isoenzymes to a New Creatine Kinase Immunolnhibltlon Test Kit, (Reply), Morin, b. G. Clin. Chem., 26. 1108 (1980).
CLINICAL CHEMISTRY (38D) Burgett, M. W., Kwan, S., Immunological Characterizatlon of the Creatine Kinase Isoenzyme! in Human Serum. Clin. Chem., 25, 2051 ( 1979). (390) Buriina, A., Improved Electrophoretic Separatlon of Creatine Kinase Isoenzymes. Clin. Chem., 26, 317 (1980). (40D) Buttery, J. E., Milner, C. R., Nenadovic, P., Pannall, P. R., Detection of Alkaline Phosphatase/Immumglobulin Complexes. Clin. Chem., 20, 1620 (1980). (41D) Cachera, C., Mizon, C., F‘ruchart, J.-C., Mizon, J., Tacquet, A., Rapid Sodium Dodecyl Sulfate/Poiyacryiamide Gel Electrophoresis of Urinary Proteins. Clin. Chem., 26, ’1588 (1980). (42D) Capel, I.D.,Jenner, M., Dorrell, H. M., Williams, D. C., Hepatic Func.. tion Assessed (in Rats) during Chemotherapy with Some Anti-Cancer Drugs. Clin. Chem., 25, 1381 (1979). (43D) Cejka, J., Kithier, K., IQI) Myeloma Protein with “Unreactive” Light Chain Determinants. Clin. Chem., 25, 1495 (1979). (44D) Chamberlain, B. R., Buttery, J. 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(73D) Fahrenkrug, J., Magid, E., Concentratlon of Immunoreactive Trypsin and Activity of Pancreatic Isoamylase in Serum Compared in Pancreatic Diseases. Clin. Chem., 26, 1573 (1980). (74D) Fareed, J., Messmore, H. L., Bermes, E. W., New Perspectives in Coagulation Testing. Clln. Chem., 20, 1380 (1980). (75D) FBrard, G., Goester, C., Klumpp, T., MBtais, P., Evaluation of Immunoephelometry of C-Reactive Protein in Serum. Clin. Chem., 20, 782 (1980). (78D) Fielek, S., Mohrenwieser, H. W., Erythrocyte Enzyme Deficiencies Assessed with a Miniature Centrifugal Analyzer. Clin. Chem., 25, 384 (1979). (77D) Flke, S. S., Immunochemical and Electrophoretic Methods for Determination of Lactate Dehydrogenase Isoenzyme 1 Compared. Clln, Chem., 20, 794 (1980). (78D) Finiey, P. R., Williams, R. J., Lichti, D. A., Griffith, F., Thies, A. C., Immunochemical Determination of Human Immunoglobulins: Use of Kinetic Turbidimetry and a 36-place Centrifugal Analyzer. Clln. Chem., 25, 526 (1979). 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CLINICAL CHEMISTRY (1070) Gupta, R. K., Morton, D. L., Double-Antibody Method and the ProteinA-Bearing Staphylococcus aureus Ceiis Method Compared for Separating Bound and Free Antigen in Radioimmunoassay. Clin. Chem., 25, 752 (1979). (108D) Gustafsson, J. E. C., Homogeneous Enzyme Immunoassay for Thyroxine Compared with a Radioimmunoassay Technique. Clin. Chem., 25, 1476 (1979). (109D) Gyure, W. L., Comparison of Creatine Kinase Formulations for Suitability in Development for Creatine Kinase Isoenzymes on Cellulose Acetate, Ciin, Chem., 25, 1179 (1979). (llOD) Hafkenscheid, J. C. M., Dijt, C. C. M., Determination of Serum Aminotransferases: Activation by Pyridoxai-5'-phosphate in Relation to Substrate Concentration. Clin. Chem., 25, 55 (1979). (11 ID) Haifman, C. J., Concentrations of Binding Protein and Labeled Anaiyte foor Optimizing the Response of Immunoassays. Anal. Chem., 51, 2306 (1979). (112D) Hanson, N. Q., Yasmineh, W. 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(129D) Josephson, L., Houie, P., Stability of Prostatic Acid Phosphatase in Normal Human Sera. Clin. Chem., 26, 1631 (1980). (130D) Jung, K., Schoiz, D., An Optimized Assay of Alanine Aminopeptidase Activity in Urine. Clin. Chem., 26, 1251 (1980)9 (131D) Kamin, R. A., Wilson, G. S.,Rotating Ring-Disk Enzyme Electrode for Biocataiysis Kinetic Studies and Characterization of the Immobilized Enzyme Layer. Anal. Chem., 52, 1198 (1980). (132D) Kaminska, J., Caivert, I., Rosen, S. W., Radioimmunoassay of Pregnancy-Specific'' /3,-Giycoprotein (SP,). Clin. Chem., 25, 577 (1979). (133D) Kattan, D., Economical Single Cellulose Acetate/Piastic Sandwich for Developing and Scanning CPK/LDH Isoenzymes. Clin. Chem., 24, 2214 (1978). (134D) Kelly. R. H., Schoii, M. A., Harvey, V. S., Devenyi, A. G., Quaiitative Testing for Circuiating Immune Complexes by Use of Zone Eiectrophoresls on Agarose. Ciin. Chem., 26, 396 (1980). (135D) Keshgegian, A. A,, Cobientz, J., Lisak, R. 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(141D) Klein, B., Jeunelot, C. L., Elution Profile of Adenylate Kinase, from Platelets, in Plasma. Clin. Chem., 25, 492 (1979). (142D) Klumpp, T., Bieth, J. G., Automated Measurement of the Eiastase-lnhibitory Capacity of Plasma by a Centrifugal Analyzer. Ciin. Chem., 25, 969 (1979). (143D) Kosta, M. J., Glenn, G. C., Radial Immunodiffusion Applied to Quantitation of Urinary Protein (Albumin). Clin. Chem., 25, 1335 (1979). (144D) Kritchevsky, D., Tepper, S. A., Assay of Plant Sterols by Use of Cholesterol Oxidase. Clm. Chem., 25, 1464 (1979). (145D) Kroiikowski, F. J., Beii, F. T., Gerson, B., Rapid Screening Technique for Polymer IgM. Clln. Chem., 25, 1673 (1979). (146D) Kubaski, N. P., Dohm, M. A,, Sine, H. E., Some Criticisms of the DADE "Cardiozyme CK-MB Reagents", (Reply), Welsh, M. Ciln. Chem., 25, 1861, (1979). (147D) Kumar, M. S., Carl, K. J., Deodhar, S. H., Improved Indirect and Direct Radioimmunoassay for Carcinoembryonic Antigen. Clln. Chem., 25, 314 (1979). 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(207D) Roe, C. R., Wagner, G. S., Young, W. G., Jr., Curtis, S. E., Cobb, F. R., Irvln, R. G., Relation of Creatine Kinase Isoenzyme MB to Postoperatlve ElectrocardiographicDiagnosis In Patients Undergoing Coronary-Artery Bypass Surgery. Clin. Chem., 25, 93 (1979). (208D) Ruch, F. E., Jr., Knight, G. J., Use of Soluble and Staphylococcus sureus-Immobilized Second Antibody Compared in a Radioimmunoassay for Human Alpha-Fetoprotein. Clin. Chem., 26, 1133 (1980). (209D) Rutkowski, R. B., Bilirubin Binding by Prlmary Sites of Human Serum Albumin, with Suppression of Secondary-She Interference by Use of a High Salt Concentration. Ciin. Chem. 26, 107 (1980). (2100) Sakai, T., Yanagihara, S., Ushlo, K. Restoratlon of Lead-Inhlblted 5-Amlnoievulinate Dehydratase Activity In Whole Blood by Heat, Zinc Ion, and (or) Dlthlothreitol. Clln. Chem., 26, 625 (1980). (21 ID) Salkle, M. L., Cox, D. W., Splitting of the a,-Globulin Zone in Electrophoretic Patterns. Clln. Chem., 25, 1863 (1979). 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CLINICAL CHEMISTRY (239D) Tarkkanen, P., Komor, S., Corneiy, C., Hacke, W., Greiiing, H., Bioiuminescence Assay of Creatine Kinase and Its Isoenzymes in Serum and Cerebrospinal Fluid. Clln. Chem., 25, 1644 (1979). (240D) Taylor, J. T., Freeman, S., Spectrophotometry of Angiotensin-Converting Enzyme in Sarcoidosis. Clln. Chem., 26, 1756 (1980). (241D) Thevenot, D. R., Sternberg, R., Couiet, P. R., Laurent, J., Gautheron, D. C., Enzyme Collagen Membrane for Electrochemical Determination of Glucose. Anal. Chem., 51, 96 (1979). (242D) Tighe, P., Jones, B., Metronidazole Interference with Continuous-Flow Spectrophotometry of Aspartate Aminotransferase. Clin. Chem., 25, 2057 (1979). (2430) Toftager-Larsen, K., Kjaersgaard, E., Jacobsen, J. C., Norgaard-Pedersen, B., Reactivity of Amniotic Fluid Alpha-Fetoprotein with Concanavalin A in Relation to Gestational Age: Clinical Implications. Clln. Chem., 26, 1656 (1980). (244D) Tran-Minh, C. 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S., Evaluation of a Nepheiometric Assay for Haptoglobin and Its Clinical Usefulness. Clln. Chem., 25, 2007 (1979). (252D) Van Steirteghem, A. C., Zweig, M. H., Bernard, R. M., Putzeys, G. A., Bieva, C. J., Creatine Kinase Isoenzyme BB Concentration in Serum as a Marker of Myocardial Infarction. Clin. Chem., 26, 1110 (1980). (253D) van Wijk, E. M., Kahle, L. H., ten Cate, J. W., Mechanized Amidolytic Technique in Determination of Factor X and Factor-X Antigen, and Its Application to Patients Being Treated with Oral Anticoagulants. Clln. Chem., 26, 885 (1980). (254D) Vernon, S. E., Clinical Application of Agarose-Gel Electrophoresis in Identifying Abnormal Hemoglobins. Clln. Chem., 26, 1230 (1980). (2550) Vihko, P., Kostama, A., Janne, O., Sajanti, E., Vihko, R., Rapid Radioimmunoassay for Prostate-Specific Acid Phosphatase in Human Serum. Clln. Chem., 26, 1544 (1980). (256D) Viipo, J. A., Irjala, K., IgD-h Myeloma with Separate Heavy- and Light-Chain M-Components. Clln. Chem., 26, 1760 (1980). (257D) Vireiia, G., Russell, D., Laimins, M., Coiweii, J., Simplified Method for Detecting Anti-Insulin Antibodies and Insulin-Anti-Insulin Immune Complexes. Clln. Chem., 26, 1357 (1980). (258D) Vireiia, G., Screening for Polymeric ISM: Some Overlooked History. Clin. Chem., 26, 533 (1980). (259D) Viadutiu, A. O., IgD Myeloma or 6 Heavy-Chain Disease? Clln. Chem., 26, 353 (1980). (260D) Viadutiu, A. O., Palumbo, D. A., Asirwatham, J. E., Antibodies to Native DNA: Detection by Immunoperoxidase Assay and Determination of Their Immunoglobulin Classes. Clin. Chem., 25, 366 (1979). (261D) Viadutiu, G. D., Giueck, C. J., Schuitz, M. T., McNeeiy, S., Guthrie, R., /%Lipoprotein Quantitation in Cord Blood Spotted on Filter Paper: A Screening Test. Clln. Chem., 26, 1285 (1980). (2621)) Wahed, M. A., Rahaman, M. M., Bisaibuminemia in Two Asian Families. Clin. Chem., 25, 1674 (1979). (263D) Waish, R. L., Coles, M. E., Binding of IgG and Other Proteins to Microfiiters. Clln. Chem., 26, 496 (1980). (264D) Waiters, R. R., Johnson, P. A., Buck, R. P., Histidine Ammonia-Lyase Enzyme Electrode for Determination of L-Histidine. Anal. Chem., 52, 1684 (1980). (265D) Wang, H.-P., Chu, C. Y.-T., A Solid-phase Enzyme-linked Immunosorbent Assay for the Quantitation of Human Plasma a,-Acid Glycoprotein. Clin. Chem., 25, 546 (1979). (266D) Watanabe, N., Niitsu, Y., Ohtsuka, S., Koseki, J., Kohgo, Y., Urushizaki, I., Kato, K., Ishlkawa, E., Enzyme Immunoassay for Human Ferritin. Clin. Chem., 25, 80 (1979). (267D) Weijers, R. N. M., Properties and Clinical Significance of an Alkaline Phosphatase--Lipoprotein-X Complex. Clln. Chem., 26, 609 (1980). (288D) Weijers, R. N. M., Kruijswijk, H., Beak, J. M., Purification of an Alkaline Phosphatase--Lipoprotein-X Complex. Clln. Chem., 26, 604 (1980). (269D) Werner, M., Maruhn, D., Dialysis of Urine in Determination of Arylsulphatase A Activity, (Reply), Posey, L. E. Clln. Chem., 25, 1668 (1979). (270D) Werner, M., Mohrbacher, R. J., Relative Merits of Creatine KinasaMB Assay by Immunoinhibition and by Electrophoresis, (Reply), Lon, J. A. Clln. Clin. Chem., 26, 1517 (1980). (271D) Whitlow, K. J., Gochman, N., Forrester, R. L., Wataji, L. J., Maitotetraose as a Substrate for EnzymeCoupied Assay of Amylase Activity in Serum and Urine. Clln. Chem., 25, 481 (1979). (2721)) Whitlow, K. J., Gochman, N., Zettner, A,, Potential Bilirubin Interference with the Technicon SMAC Alkaline Phosphatase Activity Measurement. Clln. Chem., 26, 359 (1980). (273D) Wiener, K., Foot, C. H., First Impressions of the New Phadebas Amylase Test wlth Albumin. Clln. Chem., 24, 2212 (1978). (274D) Williams, H. L., Johnson, D. J., Haut, M. J., Slater, S., Brennan, R. G., Aitstatt, L. B., Improved Radiochemical Method for Measuring Ferrocheiatase Activity. Clin. Chem., 26, 153 (1980). (275D) Woik, M., Evaluation of Standard Curves in the Graded Hemagglutination-Inhibition Method Applied to Quantitation of Human Immuno-
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globulins. Clln. Chem., 26, 654 (1980). (276D) Woik, M., Graded Hemagglutination Inhibition--A New Technique Applied to the Quantitation of Human Immunoglobulins IgG and IgA. Clln. Chem., 25, 819 (1979). (277D) Woo, J., Floyd, M., Longiey, M. A., Cannoh, D. C., Radiolmmunoassay for Immunoglobulin G in Serum and Urine. Clin. Chem., 25, 2015 (1979). (278D) Woo, J., Floyd, M., Longiey, M. A., Cannon, D. C., fl,-Microgiobuiin Clearance as Measured by Radioimmunoassay. Clln. Chem., 26, 1193 (1980). (279D) Wynalda. M. A., Fitzpatrlck. F. A., High-Performance Liquid Chromatographic Determination of 5-Haiopyrimidinone Interferon Inducers. Anal. Chem., 52, 1931 (1980). (280D) Wyse, B. W., Wittwer, C., Hansen, R. G., Radioimmunoassay for Pantothenic Acid in Blood and Other Tissues. Clln. Chem., 25, 108 (1979). (281D) Yamaguchi, Y., Non-Chromatographic Screening Test for Hyperprolinemia. Clln. Chem., 24, 2178 (1978). (282D) Yamamoti, N., Nagasawa, Y., Shuto, S., Tsubomura, H., Sawai, M., Okimura, H., Antigen-Antibody Reaction Investigated with Use of a Chemicaiiy Modified Electrode. Clin. Chem., 26, 1569 (1960). (28313) Yasmineh, W. G., Smith, B. M., Bloomfieid, C. D., DNA Nucieotidyiexotransferase of Normal Persons and Leukemic Patients. Clln. Chem., 26, 891 (1980). (284D) Yorde, L. D., Hussey, C. V., Yorde, D. E., Sasse, E. A., Competitive Enzyme-Linked Immunoassay for Factor VI11 Antigen. Clln. Chem., 25, 1924 (1979). (285D) Zweig, M. H., Sliverman, L. M., Dermer, G. B., Van Steirteghem, A. C., Serum Creatine Kinase Isoenzyme BB as an Indicator of Active Metastatic Disease. Clin. Cbem., 25, 1190 (1979). DRUG ANALYSIS, TOXIC SUBSTANCE ANALYSIS (IE) Agdeppa,, D. A., Lipton, S. D., Interference of Cephalosporin Antibiotics with Analysis for Theophylline by Liquid Chromatography. Clln. Chem., 26, 788 (1980). (2E) Ai-Bassam, M. N., O’Suiiivan, M. J., Bridges, J. W., Marks, V., Improved Double-Antibody Enzyme Immunoassay for Methotrexate. Clin. Chem., 25, 1448 (1979). (3E) Aramaki, K., Hanai, T., Walton, H. F., Liquid Chromatography of Aikaioids, Drugs, and Nitrogen Heterocycles on a Porous Polymer. Anal. Chem., 52, 1963 (1980). (4E) Back, %E., Niisson-Ehie, I., Nllsson-Ehie, P., Chemical Assay, Involving Liquid Chromatography, for AminogiycosMe Antibiotics in Serum. Clln. Chem., 25, 1222 (1979). (5E) Bailey, D. N., Guba, J. J., Gas-Chromatographic Analysis for Chiorpromazine and Some of Its Metabolites in Human Serum, with Use of a Nitrogen Detector. Clin. Chem., 25, 1211 (1979). (6E) Bailey, D. N., Guba, J. J., Gas-Chromatographic Analysis for Phencyctidine in Plasma, with Use of a Nitrogen Detector. Clln. Chem., 26, 437 (1980). (7E) Bernardo, M., Improved Sample Preparation for Measuring Anticonvuisant Drgus in Serum by “High-Performance’’ Liquid Chromatography. Clln. Chem., 25, 1861 (1979). (8E) Bianchard, J., Mohammadi, J. D., Conrad, K. A., Improved Liquid-Chromatographic Determination of Caffeine in Plasma. Clln. Chem., 26, 1351 (1980). (9E) Bock, J. L., Pierce, R., Trimethoprim Interference in Methotrexate Assays. Clln. Chem., 26, 1510 (1980). (IOE) Bond, L. W., Thornton, D. L., Trisuiapyrimidine Interference with Liquid-Chromatographic Analysis for Theophylline and Dyphyitne. Clin. Chem., 25, 1186 (1979). (11E) Bowen, J. M., Purdie, N., Circular Dichroism Spectra of Opium Alkaloids in the Solid State. Anal. Chem., 52, 573 (1980). (12E) Bowman, D. B., Aravind, M. K., Kauffman, R. E., Miceii, J. N., Sulfamethoxazole Interferes with Liquid-Chromatographic Analysis for Theophylline in Serum. Clin. Chem., 26, 1622 (1980). (13E) Bredesen, J. E., Gas-Chromatographic Determination of Dlsopyramide and Its Mono-N-Deaikyiated Metabolite in Serum with Use of a NitrogenSelective Detector. Clln. Chem., 26, 636 (1980). (14E) Bredesen, J. E., Rapid Isothermal Determination of Some Antiepileptic Drugs by Gas-Liquid Chromatography. Clln. Chem., 25, 1669 (1979). (15E) Bress, W. C., Use of an Internal Standard in a Single-Solvent ThinLaver ChromatoaraDhic Analysis for Drum of Abuse in Urine. Clln. Chem., 25, 1515(1’979), (16E) Brown, L. F., Johnson, G. F., Witte, D. L., Feld, R. D., Enzymic Inhibition Assay for Methotrexate wlth a Dlscrete Analyzer, the ABA-100. Clln. Chem., 26, 335 (1980). (17E) Butrimovitz, G. P.. Raisvs. V. A., An ImDroved Micromethod for Theo‘ phylline Determination by Reversed-Phase Liquid Chromatography. Clin Chem., 25, 1461 (1979). (18E) Caras, S., Janata, J., Field Effect Transistor Sensitive to Penicillin. Anal. Chem., 52, 1935 (1980). (19E) Case, R. V., Mezei, L. M., An Enzymatic Radioassay for Gsntamicin. Clln. Chem., 24, 2145 (1978). (20E) Chakrabarti, S. K., New Fiurometric Analysis for Mandelic and Phenyiglyoxylic Acids in Urine as an Index to Styrene Exposure. C / h . Chem., 25, 592 (1979). (21E) Cham, B. E., Bochner, F., Imhoff, D. M., Johns, D., Rowiand, M., SImuitaneous Liquid-ChromatographicQuantitation of Salicylic Acid, Sallcyiuric Acid, and Gentisic Acid in Urine. Clln. Chem., 26, 111 (1960). (22E) Cham, B. E., Johns, D., Bochner, F., Imhoff, D. M., Rowiand, M., SImultaneous LiquidChromatographic Quantitation of Salicylic Acid, Saiicyluric Acid, and Gentisic Acid in Plasma. Clln. Chem., 25, 1420 (1979). (23E) Chan, S. C., Monitoring Serum Vaiproic Acid by Gas Chromatography with Electron-Capture Detection. Clin. Chem.. 26, 1528 (1980). I
CLINICAL CHEMISTRY
(24E) Chen, I.-W., Sperllng, M., Maxon, H. R., A Commercial Digoxln Radioassay Modified for Use as an Emergency ("Stat") Procedure. Clin. Chem., 25, 1841 (1979). (25E) Chess, E. K., Gross, M. L., Determination of Tetrachlorodibenzo-pdioxins by Mass Spectrorrietric Metastable Decomposition Monitoring. Anal. Chem., 52, 2057 (1980). (26E) Chinn, D. M., Jennison, T. A., Crouch, D. J., Peat, M. A., Thatcher, G. W., Quantitative Analysis for Tricyclic Antidepressant Drugs In Plasma or Serum by Gas Chromatography--Chemical-Ionization Mass Spectrometry. z Clin. Chem., 28, 1201 (1980). (27E) Chou, D., Tsuru, M., Hoitzman, J. L., Eckfeidt, J. H., Interference by the 4-Hydroxylated Metabolite of Propranolol with Determination of Metanephrlnes by the Pisano Method. Clin. Chem., 26, 776 (1980). (28E) Christofides, J. A., Fry, 13. E., Measurement of Anticonvulsants in Serum by Reversed-Phase Ion-Pair Llquld Chromatography. Clin. Chem., 28, 499 (1980). (29E) Christophidis, N., Mihaly, G., Vajda, F., Louis, W., Comparison of Liquid-and Gas-Llquld Chromatographic Assays of 5-Fluorouracil in Plasma. Clln. Chem., 25, 83 (1979) (30E) Chu, S. Y., Oiiveras, L., Deyasi, S., Extraction Procedure for Measuring Anticonvulsant Drugs by Liiquid Chromatography, Clln. Chem., 26, 521 (1980). (3 1E) Clark, D. R., Theophyllinc8 Assay by Liquid Chromatography: Removal of Acetazolamlde Interference. Clh. Chem., 25, 1183 (1979). (32E) Daigneault, R., Larouclhe, A., Thibault, G., Amlnoglycoside Antibiotic Measurement by Biolumine!scence with Use of Plasmld-Coded Enzymes. Clin. Chem., 25, 1639 (1979). (33E) Daigneauit, R., Larouche, A., Thibault, G., Corrections to the Aminoglycoslde Review. Clin. C,hem., 26, 355 (1980). (34E) Darr, R. W., Capson, T L., Hileman, F. D., Determination of Hydrogen Cyanide in Blood Uslng Gas Chromatography with Alkali Thermlonlc Detection. Anal. Chem., 52, 1379 (1980). (35E) Dechtiaruk, W., Crawflord, R., Frye, R., Theophylllne Interference in Phenobarbital Quantitation. Clin. Chem., 25, 2055 (1979). (36E) Dhar, A. K., Kutt, H., Monitoring Diazepam and Desmethyidlazepam Concentrations in Plasma by Gas-Llquld Chromatography, with Use of a Nitrogen-Sensitive Detector. Clin. Chem., 25, 137 (1979). (37E) di Domenlco, A,, Merii, F., Boniforti, L., Camonl, I., Di Muccio, A., Taggl, F., Vergori, L., Colll, G., Elli, G., Gorni, A,. Grassl, P., Inverniui, G., Jemma, A., Luciani, L., Cattabeni, F., De Angelis, L., Galli, G., Chiabrando, C., Fanelii, R., Analytical Techniques for 2,3,7,8-Tetrachlorodibenzo-pdioxin Detection in Environmental Samples after the Industrial Accident at Sevesco. Anal. Chem., 51, 735 (1979). (38E) Dolan, J. W., van der Wail, Sj., Bannister, S. J., Snyder, L. R., O n l l n e Liquid-Chromatographic Analysis for Drugs in Serum wlth the Technicol "FAST-LC" System: Performance Data for Theophylline and for Four Commonly Used Antlconvulsants and Thelr Metabolites. Clin. Chem., 26, 871 (1980). (39E) Dooley, J. F., GUEST EDITORIAL: The Role of Clinical Chemlstry in Chemical and Drug Safety Evaluation by Use of Laboratory Anlmals. Clin. Chem., 25, 345 (1979). (40E) Duron, O., A Simple, Solid-Phase Iodine-I25 Radioimmunoassay for Theophylline. Clin. Chem., 25, 812 (1979). (41E) Eckfeldt, J. H., Light, R T., Klnetic Ethylene Qlycol Assay with Use of Yeast Alcohol Dehydrogenase. Clin. Chem., 26, 1276 (1980). (42E) .Edgerton, T. R., Moseman, R. F., Lores, E. M., Wright, L. H., Determlnatlon of Trace Amounts of Chlorinated Phenols in Human Urine by Gas Chromatography. Anal. Chem., 52, 1774 (1960). (43E) Eriksen, P. B., Anderseii, O., Homogeneous Enzyme Immunoassay of Serum Digoxin with Use of a Blchromatic Analyzer. Clln. Chem., 25, 169 (1979). (44E) Farrish, H. H., Wargin, W. A., Separation and Quantltatlon of Theophylline and Paraxanthlne by Reversed-Phase Llquid Chromatography. Clin. Chem., 26, 524 (1980). (45E) Fast, D. M.. Hannon, W. H., Burtis, C. A,, Bayse, D. D., An Interlaboratory Study of the Determination of Digoxln by Immunoassay. Clin. Chem., 26, 480 (1980). (46E) Finley, P. R., Williams, FI. J., Griffith, F., Lichti, D. A., Adaptation of the Enzyme-Multiplied Immunoassay for Methotrexate to the Centrlfugal Analyzer. Clin. Chem., 26, 341 (1980). (47E) Flachs, H., Rasmussen, J. M.; McDonald, D. M., Kabra, P. M., Renal Disease May Increase Apparent Phenytoin in Serum as Measured by Enzyme-Multiplied Immunoassay, (Reply), Rubenstein, K., Bastlani, R.. Clin. Chem., 28, 361 (1980). (48E) Fletterick, C. G., Grove, l'. H., Hohnade, D. C., LiquM Chromatographic Determinatlon of Acetaminophen in Serum. Clln. Chem., 25, 409 (1979). (49E) Flood, J. G., Bowers, G. N., McComb, R. B., Simultaneous Llquid-Chromatographic Determination of Three Antlarrhythmic Drugs: Disopyramide, Lidocalne, and Quinidine. CJln. Chem., 26, 197 (1980). (50E) Franklin, M., Gas-Chromatographic Measurement of Haloperiodol In Plasma. Clin. Chem., 28, 1367 (1980). (51E) Freeman, D. J., Rawal, W., Extraction of Underlvatized Valproic Acld from Serum before Gas Chromatography. Clin. Chem., 26, 674 (1980). (52E) Freeman, D. J., Rawal, M., Serum Anticonvulsant Monitoring by Llquid Chromatography wlth a Methanoiic Moblle Phase. Clin. Chem., 25, 810 (1979). (53E) Frutkoff, 1. W., Kidroni, G., Msnczei, J., Separation of Theophylline from Sulfamethoxazole and Ampicillin by Liquid Chromatography. Clin. Chem., 26, 1785 (1980). (54E) Gupta, R. N., Eng, F., Gupta, M. L., Gas-Chromatographic Analysis for Valproic Acid as Phenyacyl Esters. Clin. Chem., 2k, 1303 (1979). (55E) Gupta. R. N., Keane, P. M., Gupta, M. L., Valproic Acld in Plasma, as Determined by Liquid Chromatography. Clln. Chem., 25, 1984 (1979). (56E) Hahn, E., Dlmenhydrinate Interferes with Radioimmunoassay of Theophylline. Clln. Chem., 26, 1759 (1980).
(57E) Haidukewych, D., Rodin, E. A., Davenport, R., Monltoring Clorazepate Dlpotassium as Desmethyldlazepam in Plasma by Electron-Capture @asLlquld Chromatography. Clin. Chem., 28, 142 (1980). (58E) Haidukewych, D., Rodin, E. A., Monltorlng 2-Ethyl-2-phenylmalonamide In Serum by Gas-Liquid Chromatography: Application to Retrospectlve Study in Epilepsy Patlents Dosed with Prlmidone. Clin. Chem., 26, 1537 (1980). (59E) Haldukewych, D., Rodin, E. A., Variable I n Vivo Binding of Valprolc Acid in Epilepsy Patients Being Medicated with Other Anticonvulsants. Clln. Chem., 26, 1634 (1980). (60E) Halpern, E. P., Bordens, R. W., MicroencapsulatedAntibodies in Radioimmunoassay--I. Determination of Digoxin. Clin. Chem., 25, 860 (1979). (61E) Hande, K., Gober, J., Fletcher, R., Trimethoprlm Interferes with Serum Methotrexate Assay by the Competitive Protein Binding Technique. Clln. Chem., 28, 1617 (1980). (62E) Harless, R. L., Oswald, E. O., Wiiklnson, M. K., Dupuy, A. E., Jr., McDanlel, D. D., Tai, H., Sample Preparation and Gas ChromatographyMass Spectrometry Determination of 2,3,7,8-Tetrachlorodlbenzo-pdioxin. Anal. Chem., 52, 1239 (1980). (63E) Hassan, S. S. M., Elsayes, M. B., Liquid Membrane Electrode for Direct Potentlometry and Potentlometrlc Titration of Strychnine. Anal. Chem., 51, 1651 (1979). (64E) Howell, S. K., Wang, Y.-M., Hosoya, R., Sutow, W. W., Plasma Methotrexate as Determined by Llquld Chromatography, Enzyme-Inhlbition Assay, and Radloimmunoassay after High-Dose Infusion. Clln. Chem ,, 23, 734 (1980). (65E) Hummel, R. A., Shadoff, L. A,, Specificity of Low Resolution Gas Chromatography-Low Resolution Mass Spectrometry for the Detection of Tetrachlorodibenzo-pdioxin in Environmental Samples. Anal. Chem., 52, 191 (1980). (86E) James, G. P., Djang, M. H., Hamilton, H. H., False-Negative Results for Urinary Phenothiazines and Imipramlne in Forrest's Qualitative Assays. Clin. Chem., 26, 345 (1980). (67E) Jatlow, P., Bush, W., Hochster, H., Improved Liquid-Chromatographic Determinatlon of Propranolol in Plasma, with Fluorescence Detection. Clln. Chem., 25, 777 (1979). (68E) Jones, A. W., Inter- and Intra-Individual Variations In the Saliva/Blood Alcohol Ratio during Ethanol Metabolism In Man. Clin. Chem., 25, 1394 (1979). (69E) Josephson, L, Houle, P., Haggerty, M., Stability of Dilute Solutions of Gentamicin and Tobramycin. Clln. Chem., 25, 298 (1979). (70E) Kamel, R. S., Landon, J., Smith, D. S., Magnetizable Solid-Phase Fluoroimmunoassay of Phenytoin In Disposable Test Tubes. Clin. Chem., 26, 1281 (1980). (71E) Kamel, R. S., Landon, J., Smith, D. S., Novel 1251-iabeledNortriptyllne Derivatives and Their Use in Llquld-Phase or Magnetlzable Solid-Phase Second-Antibody Radioimmunoassays. Clln. Chem., 25, 1997 (1979). (72E) Kamel, R., Landon, J., Forrest, G. C., A Fully Automated, ContinuousFlow Radioimmunoassay for Methotrexate. Clln. Chem., 26, 97 (1980). (73E) Kaufman, R. A,, Tietz, N. W., Ion Effects in Measurement of Ionized Calcium with a Calclum-Selective Electrode. Clln. Chem., 26, 640 (1980). (74E) Keshavan, H. J. H., Gurbani, N. K., Dandiya, P. C., A Modified Quantltative Determination of Ampicillin In Biological Fluids. Clin. Chem., 25, 1674 (1979). (75E) Kumps, A., Mardens, Y., Simplified Simultaneous Determination of Valproic Acid and Ethosuximide in Serum In Gas-LlquM Chromatography. Clln. Chem., 26, 1759 (1980). (76E) Lacher, D. A., Valdes, R., Jr., Savory, J., Enzyme Immunoassay of Carbamazeplne with a Centrifugal Analyzer. Clin. Chem.. 25, 295 (1979)9. (77E) Lam, G., Huang, S A . , Lee, M A . , Nation, R. L., Chiou, W. L., Obviating Interference with Llquld-Chromatographic Assay of Theophylllne. Clin. Chem., 25, 1862 (1979). (78E) Lamparskl, L. L., Nestrick, T. J., Determination of Tetra-, Hexa-, Hepta-, and Octachlorodlbenzo-pdioxln Isomers In Particulate Samples at Parts per Trillion Levels. Anal. Chem., 52, 2045 (1980). (79E) Langhorst, M. L., Nestrlck, T. J., Determinatlon of Chlorobenzenes in Alr and Biological Samples by Gas Chromatography with Photolonlzatlon Detection. Anal. Chem., 51, 2018 (1979). (80E) Langhorst, M. L, Shadoff, L. A., Determlnation of Parts-per-Trlllion Concentrations of Tetra-, Hexa-, Hepta-, and Octachiorodibenzo-pdioxlns In Human Milk Samples. Anal. Chem., 52, 2037 (1980). (81E) Langlais, P. J., McEntee, W. J., Bird, E. D., Rapid Liquid-Chromatographic Measurement of 3-Methoxy-4-hydroxyphenylglycoland Other Monoamine Metabolites in Human Cerebrospinal Fluld. Clin. Chem., 28, 786 (1980). (82E) Lehane, D. P., Wlssert, P. J., Menyharth, P., Levy, A. L., Kukucka, M. A.. Enzyme Immunoassay for Serum Lidocaine In Antiarrhythmic Therapy. Clln. Chem., 25, 614 (1979). (83E) Lima, J. J., Llquld Chromatographlc Analysis of Disopyramlde and Its Mono-Ndealkylated Metabolite. Clin. Chem., 25, 405 (1979). (84E) Liu, T. Z., Oka, K. H., Spectrophotometric Screening Method for Acetamlnophen in Serum and Plasma. Clln. Chem., 26, 69 (1980). (85E) Luster, M. I.Aibro, P. W., Chae, K., Lawson, L. D., Corbett, J. T., McKlnney, J. D., Radioimmunoassay for Quantitatlon of 2,3,7,8-Tetrachiorodibenzofuran. Anal. Chem.. 52, 1497 (1980). (86E) MacKichan, J. J., Jusko, W. J., Duffner, P. K., Cohen, M. E., LlquldChromatographic Assay of Diazepam and Its Major Metabolites in Plasma. Clin. Chem., 25, 858 (1979). (87E) Maguire, K. P., Burrows, G. D., Norman, T. R., Scogglns, B. A., Evaluation of a Kit for Measurlng Tricyclic Antidepressants, (Reply), Wlen, G. H. Clin. Chem., 26, 529 (1960). (88E) Magulre, K: P., Burrows, G. D., Norman, T. R., Scoggins, B. A., BloodlPlasma Dstrlbution Ratios of Psychotropic Drugs. Clln. Chem., 26, 1624 (1980). ANALYTICAL CHEMISTRY, VOL. 53, NO. 5, APRIL 1981
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CLINICAL CHEMISTRY (89E) Maitra, S. K., Yoshikawa, T. T., Guze, L. B., Schotz, M. C., REVIEW Determinatlon of Aminoglycoside Antibiotics in Biological Fluids: A Review. Clin. Chem., 25, 1361 (1979). (90E) Mann, L. T., Jr., Determination of Theophylline In Serum by ReversedPhase Liquid Chromatography. Ciin. Chem., 25, 1336 (1979). (91E) Masoud, A. N., Dubes, G. R., Krupski, D. M., Interfering Impurities In Commerical High-Purity Methylene Chloride before and after Evaporation. Clln. Chem., 26, 2363 (1980). (92E) Mathies, J. C., Austin, M. A., Modlfled (Acetonltrile Protein-Precipitation Method of Sample Preparation for Drug Assay by Liquid Chromatography. Clin. Chem., 26, 1760 (1980). (93E) Meola, J. M., Brown, H. H., Swift, T., Fluorometric Measurement of Theophylline. Clin. Chem., 25, 1835 (1979). (94E) Meola, J. M., Rosano, T. G., Swift, T. A., Fluorometry of Ethylene Glycol in Serum. Clin. Chem., 26, 1709 (1980). (95E) Meoia, J. M., Swift, T., Brown, H. H., More Nearly Specific Fluorometry of Theophylline in Serum. Clin. Chem., 26, 534 (1980). (96E) Miceli, J. N., Aravind, M. K., A Rapid, Simple Acetaminophen Determination Is Available, (Reply), Rosenbaum, J. M., Broer, H. H., Shields, J. Clln. Chem., 26, 1627 (1980). (97E) Miceli, J. N., Aravind, M. K., Cohen, S.N., Done, A. K., Slmultaneous Measurements of Acetaminophen and Salicylate in Plasma by Liquid Chromatography. Clin. Chem., 25, 1002 (1979). (98E) Mldha, K. K., Loo, J. C. K., Hubbard, J. W. Rowe, M. L., McGiiveray, I. J., Radioimmunoassay for Chlorpromazine in Plasma. Clin. Chem., 25, 166 (1979). (99E) Miksic, J. R., Hodes, B., Eliminating 1,7-Dlmethylxanthlne Interference from Reversed-Phase Liquid-Chromatographic Analysis for Theophylline. Clln. Chem., 25, 1866 (1979). (100E) Miners, J. O., Foenander, T., Birkett, D. J., Liquid-Chromatographic Determination of 5-Fluorocytosine. Clin. Chem., 26, 117 (1980). (101E) Naito, H. K., McHenry, M. C., Lewis, L. A., Drug-Induced Dyslipoproteinemia: A Report of Two Cases. Clin. Chem., 26, 163 (1980). (102E) Nestrick, T. Jj., Lamparski, L. L., Townsend, D. I., Identlfication of Tetrachlorodibenzo-pdloxlnIsomers at the 1-ng Level by Photolytic Degradatlon and Pattern Recognition Technlques. Anal. Chem., 52, 1865, (1980). (103E) Nore, A. K., Storstein, L., Larsen, A,, Amlie, J. P., Digitalis Giycosldes in Serum, Urine, and Cerebrospinal Fluid, Determined with a Commercial Radloimmunoassay. Ciin. Chem., 26, 321 (1980). (104E) O'Leary, T. D., Howe, L. A., Geary, T. D., Improvement In a Radloimmunoassay for Digoxln. Ciln. Chem., 25, 332 (1979). (105E) Paxton, J. W., Interference of 4-Amino-4deoxy-N'a-methylpierolc Acid with the Radioimmunoassay of Methotrexate. Clin. Chem., 25, 491 (1979). (106E) Peat, M. A,, Jennison, T. A., High-Performance Liquid Chromatography of Quinidine in Plasma, with Use of a Microparticulate Silica Column. Clin. Chem., 24, 2166 (1978). (107E) Pehr, F., Improved, Highly Speciflc Barbiturate Screening in Urine by Colorimetry. Clin. Chem., 25, 1339 (1979). (108E) Petersdorf, S. H., Raisys, V. A., Opheim, K. E., Micro-Scale Method for Llquld-Chromatographic Determination of Chloramphenicol in Serum. Clin. Chem., 25, 1300 (1979). (109E) Pickering, L. K., Hoecker, J. L., Kramer, W. G., Liehr, J. G., Caprioli, R. M., Assays for Chloramphenicol Compared: Radloenzymatic, Gas Chromatographlc wlth Electron Capture, and Gas Chromatographic-Mass Spectrometric. Ciin. Chem., 25, 300 (1979). (llOE) Ragan, F. A,, Jr. Samuels, M. S.,HBe, S.A., Ory, R., Diphenydramine Interferes with Determinatlon of Phencyclidine by Gas-Liquid Chromatography. Clin. Chem., 26, 785 (1980). (111E) Raisys, V. A., Zebelman, A. M., MacMillan, S. F., Gas-Chromatographlc Determlnatlon of Mephenytoin and Desmethylmephenytoln, after Off-Column Alkylation. Clin. Chem., 25, 172 (1979). (112E) Robinson, C. A., Jr., Dobbs, J., Acetazoladine Interference wlth Theophylline Analysis by High-Performance Llquid Chromatography. Clin ., Chem., 24, 2208 (1978). (113E) Rosenbaum, J. M., Broer, H. H., Shields, J., Misleading Results in Cases of Coexisting Acetaminophen and Salicylate Overdose. Clin. Chem., 26, 673 (1980). (1 14E) Saki, 1. S.Zeid J. A,, Carbamazepine and Urinary 17-Hydroxycorticcsteroids. Ciin. Chem., 25, 495 (1979). (1 15E) Sawchuk, R. J., Cartier, L. L., Liquid-Chromatographic Method for Simultaneous Determination of Phenytoin and 5-(4-Hydroxyphenyl)-5-+henylhydantoin in Plasma and Urine. Clin. Chem., 26, 835 (1980). (116E) Scherrmann, J. M., Bourdon, R., Cross Reactivity of Dlgitoxln in Radioimmunoassay and Enzyme-Linked Immunoassay for Digoxln in Plasma. Clin. Chem., 26, 670 (1980). (117E) Schier, 0. M., Tho Gan, I.E.. Haipern, B., Korth, J., Measurement of Sodium Valproate in Serum by Direct-Insertlon Chemical-Ionization/Mass Spectrometry. Ciin. Chem., 26, 147 (1980). (118E) Schran, H. F., Schwarz, H. J., Talbot, K. C., Loeffier, L. J., Specific Radioimmunoassay of Ergot Peptlde Alkaiolds In Plasma. Clin. Chem., 25, 1928 (1979). (119E) Schwertner, H. A., Analysis of Underivatized Theophylllne by GasChromatography on a Silicone Stationary Phase, SP-2510-DA. Clin. Chem., 25, 212 (1979). (120E) Scoggins, B. A., Maguire, K. P., Norman, T. R., Burrows, G. D., REVIEW: Measurement of Tricyclic Antldepressants. Part 11. Applications of Methodology. Clin. Chem., 26, 805 (1980). (121E) Scogglns, B. A., Maquire, K. P., Norman, T. R., Burrows, G. D., REVIEW: Measurements of Tricyclic Antidepressants. Part I. A Review of Methodology. Clin. Chem., 26, 5 (1980). (122E) Shaw, E. J., Watson, R. A. A., Smith, D. S.,Continuous-Flow FluoroImmunoassay of Serum Gentamicin, with Automatlc Sample Blank Correction. Clin. Chem., 25, 322 (1979).
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(123E) Shler, G. M., Gan, I.E. T., Interference of Theophylline and Caffeine In the Gas-Chromatographic Estimation of Phenobarbital. Cllfl. Chem., 25, 1191 (1979). (124E) Soldin, S.J.. Chan, Y.-P. M., HIII, 8. M., Swanson, J. M., Llquid-Chromatographic Analysis for Methylphenldate (Ritalin) In Serum. Clin. Chem., 25, 401 (1979). (125E) Soldln, S. J., Gero, T., A Liquid-Chromatographic Analysis for Indomethacin in Serum. Clin. Chem., 25, 589 (1979). (126E) Soldin, S. J., Hill, B. M., Chan, Y.-P. M., Swanson, J. M., HIII, J. G., A Liquid-Chromatographlc Analysls for RIalinic Acid [a-Phenyl-a-(2-piperidyl) Acetic Acld] In Serum. Clln. Chem., 25, 51 (1979). (127E) St. Onge, L. M., Dolar, E., Anglim, M. A,, Least, C. J., Jr., Improved Determination of Phenobarbital, Primidone, and Phenytoin by Use of a Preparative Instrument for Extractlon, Followed by Gas Chromatography. Clin. Chem., 25, 1373 (1979). (128E) Stafford, B. E., Kabra, P. M.. Marton, L. J., Some Comments on Antlconvulsant-Drug Monitoring by Liquid Chromatography. Clin. Chem., 26, 1366 (1980). (129E) Stargel, W. W., Roe, C. R., Routledge, P. A,, Shand, D. G., Importance of Blood-Collection Tubes in Plasma Lidocaine Determinations. Clin. Chem.. 25. 617 (1979). (130E) Strojny, N., de Siiva, A. F., Laser Induced Fluorometric Analysls of Drugs. And. Chem., 52, 1554 (1980). (131E) Tisdall, P. A., Moyer, T. P., Anhalt, J. P., Liquld-Chromatographic Detection of Thlazide Diuretics in Urine. Ciin. Chem., 28, 702 (1980). (132E) Tsay, Y.-G., Wilson, L., Keefe, E., Quantitatlon of Serum Gentamicin Concentration by a Solid-Phase Immunofluorescence Method. Ciln. Chem., 26, 1610 (1980). (133E) Umstead, G. S., Rosen, J. P., Comparison of Theophylline Concentrations in Venous Blood and Capillary Blood in Asthmatlc Children. Clin. Chem., 25, 1837 (1979). (134E) Van Dyke, K., Van Dyke, C., Udeinya, J., Brister, C., Wilson, M., A New Screening System for Nonsteroidal Anti-Inflammatory Drugs Based upon Inhibition of Chemiluminescence Produced from Human Cells (Granulocytes). Clin. Chem., 25, 1655 (1979). (135E) Vasiliades, J., Owens, C., Pirkie, D., Gas-Chromatographic Determination of Disopyramide In Serum, with Use of a Nitrogen-Selectlve Detector. Clin. Chem., 25, 311 (1979). (136E) Vasiliades, J., Owens, C., Ragusa, F., Disopyramlde Determination by Gas Chromatography, Liquid Chromatography, and Gas ChromatographyMass Spectrometry. Clln. Chem., 25, 1900 (1979). (137E) Vinet, B., Zizian, L., Enzymic Assay for Serum Theophylline. Clin. Chem., 25, 1370 (1979). (138E) Vlnet, B., Zizian, L., Improved Determination of Serum Theophylline by Gas Chromatography with Use of a Nitrogen-Phosphorus Detector. Clin. Chem., 25, 156 (1979). (139E) Vogt, C. R., Liao, J. C., Sun, A. Y., Extraction and Determination of Chloroform In Rat Blood and Tlssues by Gas Chromatography-ElectronCapture Detection: Distribution of Chloroform in the Animal Body. Clln. Chem., 26, 66 (1980). 140E) Wallace, J. E., Harris, S.C., Peek, M. W., Determination of Morphine by Liquid Chromatography with Electrochemical Detection. Anal. Chem., 52, 1328 (1980). 141E) Wallace, J. E., Schwertner, H. A., Hamilton, H. E., Shlmek, E. L., Jr., Electron-Capture Gas-Liquid Chromatographic Determinatlon of Ethosuximide and DesmethylmethsuximldeIn Plasma or Serum. Clin. Chem., 25, 252 (1979). 142E) Wallace, J. E., Schwertner, H. A,, Shimek, E. L., Jr., Analysis for Diazepam and Nordiazepam by Electron-Capture Gas Chromatography and by Llquid Chromatography. Clin. Chem., 25, 1296 (1979). (143E) Werner, M., Mohrbacher, R. J., Riendeau, C. J., Gas-Liquid Chromatography of Underivatized Drugs after Chromatographlc Extractlon from Blood. Clin. Chem., 25, 2020 (1979). (144E) Wiener, K., Relative Difficulty of Procedures for Acetaminophen, (Reply), Meola, J. M. Clln. Chem., 25, 493 (1979). (145E) Wong, R. C., Burd,J. F., Carrico, R. J., Buckler, R. T., Thoma, J., Boguslaski, R. C., Substrate-Labeled Fluorescent Immunoassay for Phenytoin in Human Serum. Clin. Chem., 25, 686 (1979). TRACE ELEMENTS, BLOOD GASES, AND ANIONS (1F) Alderman, F. R. Giteiman, H. J., Improved Electrothermal Determination of Aluminum In Serum by Atomic Absorption Spectroscopy. Clin. Chem., 26, 258 (1980). (2F) Aliain, P., Mauras, Y., Determination of Aluminum In Blood, Urine, and Water by Inductively Coupled Plasma Emisslon Spectrometry. Anal. Chem., 51, 2089 (1979). (3F) Baadenhuijsen, H., SeurenJacobs, H. E. H., Determination of Total CO, in plasma by Automated Flow-Injection Analysis. Ciin. Chem., 25, 443 (1979). (4F) Bennett, D. J., Cole, F. E., Frohlich, E. D., Erwin, D. T., A Radioenzymatic Isotope-Dilution Assay for Oxalate In Serum or Plasma. Clln. Chem., 25, 1810 (1979). (5F) Blaedel, W. J., Engstrom, R. C., Reagentless Enzyme Electrodes for Ethanol, Lactate, and Malate. Anal. Chem., 52, 1691 (1980). (6F) Bogusz, M., Moroz, J., Karski, J., Gierz, J., Regleli. A., Witkowski, R., Golabek, A., Blood Cyanide and Thiocyanate Concentrations after Administration of Sodlum Nitroprusside as Hypotensive Agent In Neurosurgery. Clin. Chem., 25, 60 (1979). (7F) Boone, J., Hearn, T., Lewls, S.,Comparison of Interlaboratory Results for Blood Lead with Results from a Definitive Method. Clin. Chem., 25, 389 (1979). (8F) Carmack, G. D., Evenson, M. A., Determination of Cadmium in Urine by Electrothermal Atomic Absorption Spectrometry. Anal. Chem., 51, 907 (1979). (9F) Ceriotti, F., Ceriotti, G., Improved Direct Specific Determination of Serum Iron and Total Iron-Bindlng Capacity. Clin. Chem., 26, 327 (1980).
CLINICAL CHEMISTRY (1OF) Chang, L. B. F., Frasur, C. G., Comparison of Liquid Control Materials for pH, Pco, and Po2 measurement. Clln. Chem., 26, 667 (1980). (1 IF) Cohen, S. A,, Daza, I. E., Calmagite Method for Determination of Serum Magnesium Modified. Clin. Chem., 26, 783 (1980). (12F) Cohen, S. A,, Sideman, L., Modification of the oCresoiphthaiein Complexone Method for Determininq Calcium. Clin. Chem., 25, 1519 (1979). (13F) Collier, H. B., Binding (of Zn2 by Buffers. Clin. Chem., 25, 495 (1979). (14F) Coutsellnis, A,, Trlchopoulos, D., Zavitslanos, X., Low Blood Lead Concentrations and Hemopoiesis. Clln. Chem., 25, 1339 (1979). (15F) Dalferes, E. R., Jr., Webber, L. S., Radhakrishnamurthy, B., Berenson, G. S., Continuous-Flow (AutoAnalyzer I)Analysis for Plasma Thiocyanate as an Index to Tobacco Smoking. Clln. Chem., 26, 493 (1980. (16F) de Jong, E. 8. M., Eioldschmidt, H. M. J., van Alphen, A. C. C. M., Loog, J. A., An Improved Automated Method for Serum Chloride. Clin. Chem., 26, 1233 (1980). (17F) Dennis, R. C., Valeri, C. R., Measuring Percent Oxygen Saturatlon of Hemoglobulin, Percent Carboxyhemoglobin and Methemoglobin, and Concentrations of Total Hemoglobin and Oxygen in Blood of Man, Dog, and Baboon. Clin. Chem., 28, 1304 (1980). (18F) Doumas, B. T., Hause, L. L., Sciacca, R. D., Jendrzejczak, B., Foreback, C. C., Hoover, J. D., Spencer, W. W., Smock, P. L., Performance of the Du Pont aca Ammonia Method. Clin. Chem., 25, 175 (1979). (19F) Duriiat, H., Comtat, M., Reagentless Amperometric Lactate Electrode. Anal. Chem., 52, 2109 (1980). (20F) Egan, J. D., Wells, I.C., Acetate Intolerance and an Inhibitor of Acetate Utilization in Hemodialysis Patients. Clin. Chem., 25, 379 (1979). (21F) Everson, J., Patterson, C. C., “Ultra-Clean” Isotope DiiutionlMass Spectrometric Analyses for Lead in Human Blood Plasma Indicate That Most Reported Values are Artificially High. Clin. Chem., 26, 1603 (1980). (22F) Farrington, C. J., Chaimers, A. H., Gas-Chromatographic Estlmation of Urinary Oxalate and Its Comparison with a Colorlmetric Method. Clin. Chem., 25, 1993 (1979). (23F) Fisenne, I. M., Perry, P. M., Welford, G. A,, Determination of Uranium Isotopes in Human Bone Ash. Anal. Chem., 52, 777 (1980). (24F) Gajda, A., Disposal of Mercury in Chloride-Reagent Waste. Clin. Chem., 25, 807 (1979). (25F) Gatzy, J. T., Zaytoun, M. P., Gaskins, K., Pearlman, W. H., Electrolytes of Breast-Cyst Fluid. Clin. Chem., 25, 745 (1979). (26F) Geahchan, A., Chambon, P., Fluorometry of Selenium in Urlne. Clin. Chem., 26, 1272 (1980). (27F) Gorsky, J. E., Dietz, A. A,, Spencer, H., Osis, D., Metabolic Balance of Albumin Studied in Six Men. Clin. Chem., 25, 1739 (1979). (28F) Gosling, P., Legg, E. F., Sammons, H. G., pH-Dependent Adsorption of Calcium onto Stainless Steel. Clin. Chem., 25, 1336 (1979). (29F) Gotelli, G. R., Wall, J. H., Kabra, P. M., Marton, L. J., Slmultaneous Liquid-Chromatographic Determination of Zlnc Protoporphyrin IX, Protoporphyrin IX, and Coproporphyrin in Whole Blood. Clin. Chem., 26, 205 (1980). (30F) Graham, G., Kenny, M. A., Performance of a Radiometer transcutaneous Oxygen Monitor In a Neonatal-Intensive-Care Unit. Clin. Chem., 26, 629 (1980). (31F) Greenberg, R. R., Slmultaneous Determination of Mercury and Cadmium in Biological Materials by Radiochemical Neutron Activatlon Anaiysls. Anal. Chem., 52, 676 (1980). (32F) Griebel, R. J., Knoblook, E. C., Koch, T. R., Fluorometrlc Calcium Titration: Interference frorn Hemolysls Estimated. Clin. Chem., 25, 1983 (1979). (33F) Guillard, O.,Piriou, A., Mura, P., Reiss, D.. Zinc Contamination of Control Serum. Clin. Chem., 25, 1867 (1979). (33F) Handy, R. W., Zn Contamination in Vacutainer Tubes. Clln. Chem., 25, 197 (1979). (34F) Hikuma, M., Kubo, T., Yasuda, T., Karube, I., Suzuki, S., Ammonia Electrode with Immobiliztrd Nitrifying Bacteria. Anal. Chem., 52, 1020 (1980). (35F) Hood, L. C., Noble, W. E.,Smith, E. K., Negllgibie Halothane Carryover In the I L 813 Blood Gas Analyzer. Clin. Chem., 26, 675 (1980). (36F) Howard, J. M. H., Serum Nickel in Myocardial Infarction. Clin. Chem., 26, 1515 (1980). (37F) Huisman, W., Interference of Imferon In Colorimetric Assays for Iron. Clin. Chem., 26, 635 (19,BO). (38F) Humphries, B. A., Melnychuk, M., Donegan, E. J., Snee, R. D., Automated Enzymatic Assay for Plasma Ammonia. Clin. Chem., 25, 26 11979). (39F) Iyengar, G. V., Borberg, H., Kasperek, K., Kiem, J., Slegers, M., Feinendegen, L. E., Gross, R., Elemental Composltion of Platelets. Part I. Sampling and Sample Preparatlon of Platelets for Trace-Element Analysls. Clin. Chem., 25, 699 (1979). (40F) Jacobson, D., Forman, D. T., Optimizlng the Dlrect Analysis of Phosphate in Serum. Clin. Chwn., 25, 1510 (1979). (41F) Kasperek, K., Iyengar, G. V., Kiem, J., Borberg, H., Feinendegen, L. E., Elemental Composltion of Platelets. Part 111. Determination of Ag, Au, Cd, Co, Cr, Cs, Mo, Rb, Sb, and Se in Normal Human Platelets by Neutron Activation Analysis. Clin. Chem., 25, 711 (1979). (42F) Kayne, F. J., Komar, G., Laboda, H., Vanderlinde, R. E., Atomic Absorption Spectrophotometry of Chromium in Serum and Urine with a Modified Perkin-Elmer 603 Atornlc Absorption Spectrophotometer. Clln Chem., 24, 2151 (1978). (43F) Kelson, J. R., Criticism of the Proposed Selected Method: Direct Measurement of Zinc in Plasma by Atomic Absorption Spectroscopy, (Reply), Smith, J. C., Jr., Butrlmovltz, 0. P., Purdy, W. C. Clin. Chem., 26, 349 (1980). (44F) Kiem, J., Borberg, H., Iyengar, G. V., Kasperek, K., Siegers, M., Felnendegen, L. E., Gross, R., Elemental Composition of Platelets. Part 11. Water Content of Normal Human Platelets and Measurements of Their Concentrations of Cu, Fe, I
