Downloaded by 80.82.77.83 on April 19, 2018 | https://pubs.acs.org Publication Date: May 15, 2000 | doi: 10.1021/bk-2000-0752.pr001
Preface The advent of a new millennium provides a somewhat unique opportunity for both reflection and projection. It seems that everyone awaits the beginning of the new millennium with some degree of anticipation. Indeed, great expectations have been imposed for significant advances in areas ranging from aquaculture to the Unified Field Theory. With similar expectations, a symposium entitled "Drug Delivery in the 2 Γ Century" was held at a recent meeting of the American Chemical Society (ACS) (March 1999 in Anaheim, California). A n outstanding group of research scientists from both academics and industry were brought together and given the opportunity to express not only their views of what has been accomplished in various delivery technologies but also prophetic views of drug delivery possibilities for the next millennium. Their common focus of future drug delivery possibilities was driven by expectations that advances made by the medical research community will allow improvements in both the quality of life and the duration of life expectancy. As with previous medical advances, the success of future treatments will require the demonstration of both safety and efficacy. It was anticipated that, more than ever before, the clinical success of future advances made by medical research will require the application of drug delivery technologies. As one might imagine, it is also assumed that as more complex medical technologies are developed, more creative forms of delivery will be required for their successful clinical application to ensure maximum efficacy and minimal side effects. The speakers brought together for this symposium did a magnificent job of providing that spark of creativity. Their concepts have now been incorporated into the chapters of this book. We have divided the many topics of these presentations into six sections. The first section focuses on design considerations and challenges in oral drug delivery. In the second section, strategies to improve drug delivery are high lighted. Drug targeting approaches is the topic for the third section. Self-regulated and modulated drug delivery technologies are the focus of the fourth section. Delivery of hydrophobic drugs using new delivery vehicles is discussed in the fifth section. Polymeric therapeutics in the next century is the subject of the final section. Background information in each chapter allows the novice to gain an ap preciation for that particular area while state-of-the-art data is presented as a platform for future projections. In the past, numerous advances in medical technology were made that never came to fruition due to inadequate drug delivery. Frequently, timing was a major culprit. A s a new medical advance is identified, the required need for drug delivery for its clinical success is identified only at a late stage in its development. Thus, the successful application of a drug delivery technology typically requires that it be ready at the same time as an advance occurs in a medical technology so
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that the two technologies can be melded at an early stage of development. This timing issue is not a simple one to overcome. It is relatively easy to look back on these missed opportunities and identify what should have been done. The problem becomes much more challenging when future drug delivery needs must be anticipated so they can be available for cohesive integration as new medical technologies are identified. Without a crystal ball, this task of identifying drug delivery technologies needed for the future requires astute anticipation. This book is a platform where some of the brightest and most far-thinking researchers in drug delivery have been given the opportunity to state where they feel future needs will be in their specific area of study. Motivation for this book at this time comes from the upcoming transition from the 20 to the 21 century. Such a momentous occasion seems appropriate for evaluating the past and making plans for the future. The past and future of drug delivery, however, is different for everyone who is involved in this field. It is different for everyone because they not only view drug delivery from different perspectives but also with different time frames. For example, a chemist may focus on synthetic events that take months to accomplish whereas a biologist may focus on biocompatibility studies that take years to complete. Only through a combination of efforts using multiple disciplines does a new drug delivery technology obtain acceptability for clinical application. A l l together, these efforts take several to many years to complete. So when one thinks of the title of this book, a question of how far into the next millennium can one look becomes valid. In reality, it would be hard to imagine looking farther than the first century of the next millennium. In essence that may be as far as our current disciplines, current understanding of biological processes, and current synthetic capabilities can allow us to look. Thus, this book is a testament to what has been and what can be achieved through innovative drug delivery technologies. But no one really knows how far this can take us into the next millennium. Our deepest appreciation goes to Abbott Laboratories (Hospital Products Division), the A C S Division of Polymer Chemistry, Inc., Amgen, Bristol-Myers Squibb Company, Glaxo Wellcome Inc., Genentech Inc., GeneMedicine Inc., Immunex Inc., Merck Research Labs, Pharmacia and Upjohn, Schering-Plough Corp., Soffinova Inc., and Yamanouchi Shaklee Pharma. Without the generous support of these institutions, the "Drug Delivery in the 21 Century" symposium and this book could not have been possible. Their contributions have allowed us to peer into the future.
Downloaded by 80.82.77.83 on April 19, 2018 | https://pubs.acs.org Publication Date: May 15, 2000 | doi: 10.1021/bk-2000-0752.pr001
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KINAM PARK
Purdue University School of Pharmacy West Lafayette, IN 47907 RANDALL J. MRSNY
Department of Pharmaceutical Research and Development Genentech Inc. South San Francisco, C A 94080
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