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Copper-Based Nanomaterials for Cancer Imaging and Therapy Min Zhou, Mei Tian, and Chun Li Bioconjugate Chem., Just Accepted Manuscript • DOI: 10.1021/acs.bioconjchem.6b00156 • Publication Date (Web): 19 Apr 2016 Downloaded from http://pubs.acs.org on April 20, 2016
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Bioconjugate Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
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Bioconjugate Chemistry
Copper-Based Nanomaterials for Cancer Imaging and Therapy
Min Zhou1, 2, 3, Mei Tian2*, Chun Li1*
1
Departments of Cancer Systems Imaging
The University of Texas M. D. Anderson Cancer Center 1881 East Road, Houston, TX 77054 2
Current Address: Department of Nuclear Medicine, The Second Affiliated Hospital of
Zhejiang University School of Medicine, 88 Jiefang Road, Zhejiang University, Hangzhou, Zhejiang 310009, China 3
Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310009,
China
*Corresponding Authors:
[email protected] [email protected] 1
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ABSTRACT: Copper based nanoparticles (NPs) have attracted increased attention for biomedical applications. Copper chalcogenide NPs exhibit strong absorption in near-infrared region, demonstrate highly efficient light-to-heat transformation under near-infrared laser irradiation, and cause selective thermal destruction to the tumor. Smaller copper NPs display its fluorescence signal and capability for optical imaging. Copper based NPs also serve as a versatile vehicle for drug delivery and image-guided therapy. This review covers recent advances related to the biomedical application of copper based NPs, with a focus on cancer imaging and therapy. We also discuss challenges to their successful clinical translation.
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Bioconjugate Chemistry
1. INTRODUCTION The two major classes of nanoparticles (NPs) with tunable optical absorption in the near-infrared (NIR) region are noble metals and semiconductor NPs.1 The absorption properties of these NPs originate from localized surface plasmon resonances (LSPRs). Plasmonic gold NPs of various shapes, such as gold nanoshells,2,3 gold nanorods,4,5 gold nanocages,6 and hollow gold nanospheres,7,8 have been explored extensively for biomedical applications, especially for photothermal therapy, (PTT), photoacoustic imaging (PAI), and light-triggered drug delivery.9 However, several important variables, such as complicated and high cost of synthesis, non-degradability, and strong dependence on the dielectric function of the surrounding medium, present considerable obstacles for further development. As an alternative to gold NPs, copper based chalcogenide semiconductor NPs, especially copper monosulfide (CuS) NPs, have emerged as a new class of photothermal conducting agent.10-15 CuS NPs can be synthesized using a remarkably simple process that involves initiating chemical reactions in an aqueous solution. When compared to gold nanostructures, CuS NPs afford several major advantages in terms of their translational potential. First, their absorption can be tuned by adjusting the particle size, but only minimally affected by post synthesis treatments or the surrounding environment.16 Second, near-infrared (NIR)-absorbing CuS NPs can be formulated to a much smaller size (
