Article pubs.acs.org/joc
Copper-Granule-Catalyzed Microwave-Assisted Click Synthesis of Polyphenol Dendrimers Choon Young Lee,* Rich Held, Ajit Sharma, Rom Baral, Cyprien Nanah, Dan Dumas, Shannon Jenkins, Samik Upadhaya, and Wenjun Du* Department of Chemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States S Supporting Information *
ABSTRACT: Syringaldehyde- and vanillin-based antioxidant dendrimers were synthesized via microwave-assisted alkyne− azide 1,3-dipolar cycloaddition using copper granules as a catalyst. The use of Cu(I) as a catalyst resulted in copper contaminated dendrimers. To produce copper-free antioxidant dendrimers for biological applications, Cu(I) was substituted with copper granules. Copper granules were ineffective at both room temperature and under reflux conditions (
