Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian

Addition/Correction Cite This: J. Nat. Prod. XXXX, XXX, XXX−XXX

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Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii Susan Matthew, Peter J. Schupp, and Hendrik Luesch* J. Nat. Prod. 2008, 71, 1113−1116, 10.1021/np700717s

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apratoxin E is the only natural member of the apratoxin family identified so far that has an R configuration at that position.

n the original paper we did not unambiguously identify the absolute configuration of the thiazoline at C30 but proposed the following: “The configuration at C30 is speculated to be S based on biosynthetic grounds since the other natural apratoxins from Apra Harbor also occur with 30S configuration.” However, through total synthesis we have now shown that the configuration is 30R and not 30S (Figure 1),1 indicating that

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REFERENCES

(1) Wu, P.; Cai, W.; Chen, Q.-Y.; Xu, S.; Yin, R.; Li, Y.; Zhang, W.; Luesch, H. Org. Lett. 2016, 18, 5400−5403.

Figure 1. Originally proposed structure of apratoxin E (30S) and corrected structure (30R).

© XXXX American Chemical Society and American Society of Pharmacognosy

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DOI: 10.1021/acs.jnatprod.7b00982 J. Nat. Prod. XXXX, XXX, XXX−XXX