Correction to “Total Synthesis of (−)-Sarain A” - Journal of the

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Correction to “Total Synthesis of (−)-Sarain A” Michael H. Becker, Peter Chua, Robert Downham, Christopher J. Douglas, Neil K. Garg, Sheldon Hiebert, Stefan Jaroch, Richard T. Matsuoka, Joy A. Middleton, Fay W. Ng, and Larry E. Overman* J. Am. Chem. Soc. 2007, 129, 11987−12002. DOI: 10.1021/ja074300t

T

he enantioselective total synthesis described in this article afforded the natural enantiomer of sarain A, as confirmed by CD comparisons with the natural product.1 Natural sarain A, isolated from the sponge Reniera sarai, whose optical rotation is reported to be [α]D +66 (c 1.3, CHCl3),1a is erroneously referred to as (−)-sarain A in this publication. The title of this article and other mentions of (−)-sarain A in the publication should be changed to (+)-sarain A. Insufficient amounts of synthetic sarain A were prepared to allow a reliable optical rotation to be measured, resulting in this errorwhich propagated from an early model study in the enantiomeric seriesnot being detected at the time of publication.

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REFERENCES

(1) (a) Cimino, G.; Mattia, C. A.; Mazzarella, L.; Puliti, R.; Scognamiglio, G.; Spinella, A.; Trivellone, E. Tetrahedron 1989, 45, 3863−3872. (b) Guo, Y.; Madaio, A.; Trivellone, E.; Scognamiglio, G.; Cimino, G. Tetrahedron 1996, 52, 8341−8348.

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DOI: 10.1021/jacs.8b03357 J. Am. Chem. Soc. XXXX, XXX, XXX−XXX