Correction to Discovery of N-Alkyl Catecholamides as Selective

Correction pubs.acs.org/chemneuro

Cite This: ACS Chem. Neurosci. XXXX, XXX, XXX−XXX

Correction to Discovery of N‑Alkyl Catecholamides as Selective Phosphodiesterase‑4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses Zhong-Zhen Zhou,* Yu-Fang Cheng, Zheng-Qiang Zou, Bing-Chen Ge, Hui Yu, Cang Huang, Hai-Tao Wang, Xue-Mei Yang,* and Jiang-Ping Xu*

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ACS Chem. Neurosci. 2017, 8 (1), 135−146. DOI: 10.1021/acschemneuro.6b00271 ecently, a typo in our 2017 article, “Discovery of N-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses”, was discovered. In the original version, the units of AUC(0−t), AUC(0−∞) and Cmax in Table 5 on page 141 are (ng·h/L), (ng·h/L), and (ng/L) respectively. In fact, the units of AUC(0−t), AUC(0−∞) and Cmax in Table 5 are (ng·h/mL), (ng·h/mL), and (ng/mL) respectively. The corrected Table 5 is as follows:

R

Table 5. Pharmacokinetic Profile of PDE4 Inhibitor 10j in Mice/Rats

route iv (1 mg/kg)

CL (L h−1 kg−1)

Vss (L kg−1)

2.70 ± 0.16

4.38 ± 1.06

route po (5 mg/kg)

MRT(0−∞) (h) AUC(0−t) (ng·h/mL) AUC(0−∞) (ng·h/mL) 0.57 ± 0.09

367 ± 22.72

371.29 ± 22.73

Cmax (ng/mL)

T1/2 (h)

Tmax (h)

857.77 ± 36.27

1.13 ± 0.28

0.083 ± 0.00

MRT(0−∞) (h)

AUC(0−t) (ng·h/mL)

AUC(0−∞) (ng·h/mL)

Cmax (ng/mL)

T1/2 (h)

Tmax (h)

F (%)

5.44 ± 1.76

6.82 ± 1.53

22.81 ± 5.34

5.60 ± 1.42

3.69 ± 1.17

0.194 ± 0.096

1.23 ± 0.29

© XXXX American Chemical Society

A

DOI: 10.1021/acschemneuro.8b00273 ACS Chem. Neurosci. XXXX, XXX, XXX−XXX