Addition/Correction Cite This: J. Med. Chem. XXXX, XXX, XXX−XXX
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Correction to Discovery of New Chemical Entities for Old Targets: Insights on the Lead Optimization of Chromone-Based Monoamine Oxidase B (MAO-B) Inhibitors Joana Reis, Fernando Cagide, Daniel Chavarria, Tiago Silva, Carlos Fernandes, Alexandra Gaspar, Eugenio Uriarte, Fernando Remiaõ , Stefano Alcaro, Francesco Ortuso, and Fernanda Borges* Journal of Medicinal Chemistry 2016, 59, 5879−5893. DOI: 10.1021/acs.jmedchem.6b00527 N-(3′-Chlorophenyl)-4-oxo-4H-chromene-3-carboxamide, compound 20 (IC50 = 403 pM), acts as noncompetitive reversible inhibitor, and N-(3′,4′-dimethylphenyl)-4-oxo-4Hchromene-3-carboxamide, compound 27 (IC50 = 669 pM), acts as competitive reversible inhibitor. Therefore, the following corrections to the above article are as follows. Page 5879. In the abstract, line 9, “N-(3′-chlorophenyl)-4oxo-4H-chromene-3-carboxamide (20)” should be “N-(3′chlorophenyl)-4-oxo-4H-chromene-3-carboxamide (27)”. Page 5884. In Figure 3 “mechanism of hMAO-B inhibition by chromones 20 (A) and 27 (B)” should be “mechanism of hMAO-B inhibition by chromones 27 (A) and 20 (B)”. Page 5885. Line 4, “Concerning compound 20” should be “Concerning compound 27”. Page 5885. Line 6, “different concentrations of 20” should be “different concentrations of 27”. Page 5885. Line 8, “As for compound 27” should be “As for compound 20”. Page 5885. Line 11, “for different concentrations of compound 27” should be “for different concentrations of compound 20”. Page 5885. Line 19, should be “Chromones 27 (Figure 3A) and 20 (Figure 3B)” instead of “Chromones 20 (Figure 3A) and 27 (Figure 3B)”. Page 5885. Lines 23−26, should be “27 (IC50 = 0.67 nM) displayed IC50 and Ki values within the picomolar range, and compound 20 (IC50 = 0.40 nM), as a noncompetitive inhibitor, also showed a Ki extremely close to its IC50” instead of “20 (IC50 = 0.40 nM) displayed IC50 and Ki values slightly different but within the picomolar range, and compound 27 (IC50 = 0.67 nM), as a noncompetitive inhibitor, showed a Ki equal to its IC50.” Page 5887. In the Conclusion, line 12, “competitive IMAOB” should be “noncompetitive IMAO-B”. Page 5887. In the Conclusion, line 14, “a noncompetitive IMAO-B” should be “a competitive IMAO-B”.
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DOI: 10.1021/acs.jmedchem.8b00600 J. Med. Chem. XXXX, XXX, XXX−XXX
